A5058078137- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Nanoparticle-Based Drug Delivery
- Micro and Nano Robotics
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Immune cells in cancer
- Systemic Sclerosis and Related Diseases
Children's Hospital of Philadelphia
2025
Physical Sciences (United States)
2022-2023
University of Pennsylvania
2021-2023
The longitudinal cellular interactions that drive pulmonary fibrosis are not well understood. To investigate the disease underpinnings associated with onset and progression, we generated a scRNA-seq atlas of lungs from young aged mouse models multiple subtypes Hermansky-Pudlak syndrome (HPS), collection rare autosomal recessive diseases albinism, platelet dysfunction, fibrosis. We have identified an age-dependent increase in SAA3+ inflammatory lung fibroblasts HPS mice, including...
Abstract Macrophages are abundant in solid tumours and typically associate with poor prognosis, but macrophage clusters tumour nests have also been reported as beneficial even though dispersed macrophages would more contacts cancer cells. Here, by maximizing both phagocytic activity numbers, we discover cooperative phagocytosis low entropy rapidly growing engineered immuno-tumouroids. The results fit the calculus of proliferation-versus-engulfment, rheological measurements molecular...