A5015750037- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Solid-state spectroscopy and crystallography
- Chemical Synthesis and Characterization
- Ion-surface interactions and analysis
- X-ray Diffraction in Crystallography
- Viral gastroenteritis research and epidemiology
- Synthesis and Properties of Aromatic Compounds
- Viral Infections and Immunology Research
- Lanthanide and Transition Metal Complexes
- SARS-CoV-2 and COVID-19 Research
- Luminescence and Fluorescent Materials
Gilead Sciences (United States)
2023
University of Kansas
2009-2017
University of Kentucky
2012-2017
Remdesivir 1 is an phosphoramidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells, thereby forming bioactive triphosphate 2-NTP. 2-NTP, analog ATP, inhibits SARS-CoV-2 RNA-dependent RNA polymerase replication and transcription viral RNA. Strong clinical results for have prompted interest in oral approaches to generate Here, we describe discovery a 5′-isobutyryl ester 2 (GS-5245, Obeldesivir, 3) has low cellular cytotoxicity 3–7-fold improved delivery...
A variety of particle sizes a model compound, dicumarol, were prepared and characterized in order to investigate the correlation between size solid-state NMR (SSNMR) proton spin-lattice relaxation (1H T1) times. Conventional laser diffraction scanning electron microscopy used as measurement techniques showed crystalline dicumarol samples with ranging from tens micrometers few micrometers. Dicumarol using both bottom-up top-down control approaches, via antisolvent microprecipitation...
Nanomaterials have emerged as valuable tools in biomedical imaging techniques. Here, the synthesis and characterization of a novel fluorinated nanoparticle with potential applications an MRI contrast agent is reported. Particles were synthesized using free radical polymerization technique. Secondary ion mass spectrometry analysis showed that particles' surface contained groups nitrogen-containing groups. Solid-state NMR spectroscopy suggested presence two distinct fluorine resonances, which...