A5078107618- Helicobacter pylori-related gastroenterology studies
- Insect Resistance and Genetics
- Venomous Animal Envenomation and Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant and fungal interactions
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Insect and Pesticide Research
- Ferroptosis and cancer prognosis
- Ion Channels and Receptors
- Entomopathogenic Microorganisms in Pest Control
- Historical and Environmental Studies
- Cancer-related gene regulation
- Sodium Intake and Health
- Phytochemistry and Biological Activities
- Insect symbiosis and bacterial influences
- Vasculitis and related conditions
- Olfactory and Sensory Function Studies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Invertebrate Immune Response Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare and Venom Research
- Histone Deacetylase Inhibitors Research
Centro di Riferimento Oncologico della Basilicata
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Società Italiana di Nefrologia
2023
University of Basilicata
2014-2016
National Graduate Institute for Policy Studies
2014
University of Cambridge
2012
University of Naples Federico II
2005-2010
University of Campania "Luigi Vanvitelli"
2007-2010
ASL Roma
2009
Rituximab is effective induction therapy in refractory or relapsing antineutrophil cytoplasmic antibody-associated vasculitis (AAV). However, further relapse common, and maintenance strategies are required. The aim of this study was to reduce rates using a fixed-interval rituximab re-treatment protocol.Retrospective, standardized collection data from sequential patients receiving for AAV at single center studied. Group A (n = 28) received (4 infusions 375 mg/m(2) 2 1 gm) the time subsequent...
Background. Tumour necrosis factor alpha (TNFα) is implicated in the pathogenesis of ANCA-associated systemic vasculitis (AASV). There a need for more effective and safer induction therapies AASV. Uncontrolled studies have pointed to efficacy TNFα blockade with infliximab remission vasculitides. We hypothesized that adjunctive treatment humanized anti-TNFα monoclonal antibody, adalimumab, will permit rapid reduced prednisolone exposure Methods. This Phase II, open-label, prospective study...
Gastric cancer (GC) is a leading cause of cancer-related deaths in the world. Molecular heterogeneity major determinant for clinical outcomes and an exhaustive tumor classification currently missing. Histologically normal tissue adjacent to (NAT) commonly used as control studies, nevertheless recently published paper described unique characteristics NAT several types. Little known about global gene expression profile gastric (gNAT) which could be effective tool more realistic definition GC...
Gastric cancer, the second most common cause of death worldwide, is characterized by poor prognosis and low responsiveness to chemotherapy. Indeed, multidrug resistance, based mainly on cellular molecular factors, remains one limiting factors current approach gastric cancer (GC) therapy. We employed a comprehensive gene expression analysis through data mining publicly available databases assess role signal transducer activator transcription 3 (STAT3) in drug efficiency. It has been proposed...
Gastric cancer (GC) is one of the leading causes cancer-related mortality worldwide, characterised by poor prognosis and limited responsiveness to chemotherapy. There a need for new more effective anticancer agents. Antimicrobial peptides (AMPs) represent promising class biomolecules this purpose. Naturally occurring in innate immune system, these can also exert cytotoxic effects against cells, earning them designation "anticancer peptides" (ACPs). They have potential be viable support...
Gastric cancer (GC) is characterized by poor efficacy and the modest clinical impact of current therapies. Apoptosis evasion represents a causative factor for treatment failure in GC as other cancers. Since intracellular calcium homeostasis regulation has been found to be associated with apoptosis resistance, aberrant expression regulator genes (CaRGs) could have prognostic value patients. We analyzed association levels 98 CaRGs prognosis log-rank test collection 1524 samples from four gene...
The peculiar aspect that emerges from the study of Orchidaceae is presence various molecules, which are particularly interesting for pharmaceutical chemistry due to their wide range biological resources. aim our was investigate properties two dihydrophenanthrenes, isolated, first time, Himantoglossum robertianum (Loisel.) P. Delforge (Orchidaceae) bulbs and roots. Chemical spectroscopic roots Himantoglossumrobertianum resulted in isolation known dihydrophenanthrenes-loroglossol...
CFHR5 nephropathy is considered a subtype of C3 glomerulopathy. It was originally described in Greek Cypriot families and it characterized by the time with development microscopic hematuria proteinuria associated fast progression towards ESKD especially men. These symptoms present an autosomal dominant inheritance pattern are exon 2 to 3 duplication gene. Here, we describe novel clinical phenotype variant CFHR5. The affected subjects features Autosomal Dominant Tubulo-interstitial Kidney...
JAK2V617F mutational status is an essential diagnostic index in myeloproliferative neoplasms (MPNs). Although widely used for detection of JAK2 V617F mutation peripheral blood (PB), sensitive real-time quantitative PCR (qPCR) presents some methodological limitations. Recently, emerging alternative technologies, like digital droplet (ddPCR), have been reported to overcome qPCR's technical drawbacks. The purpose this study was compare the utility ddPCR qPCR and quantification samples from MPNs...
Epithelioid sarcoma (ES) is a rare disease representing <1% of soft tissue sarcomas. Current therapies are based on anthracycline alone or in combination with ifosfamide other cytotoxic drugs. ES still characterized by poor prognosis high rates recurrence. Indeed, for years, survival have remained stagnant, suggesting that conventional treatments should be revised and improved. New therapeutic approaches focused to target the key regulators signaling pathways, causative markers tumor...
The correlation between cancer and venous thromboembolism (VTE) is solid, whereas the knowledge about cancer-related arterial (ATE) still needs a deeper investigation to clarify its pathogenesis. We describe two cases that represent useful hints for comprehensive review of thrombotic issue. A 75-year-old man with advanced rectal treated fluoropyrimidines suffered catheter-related VTE events managed according current guidelines. There was no indication “extended” anticoagulant therapy him,...
Background and objectives: Intrapatient variability of hemoglobin (Hb) is a newly proposed determinant adverse outcome in chronic kidney disease (CKD). We evaluated whether intensity epoetin therapy affects Hb renal survival nondialysis CKD. Design, setting, participants, & measurements: calculated the individual therapeutic index (TI) for (EPO; difference between rates visits that required EPO dosage change those with effective change) from 1198 during first year 137 patients. Renal death...
While enolase is a ubiquitous metalloenzyme involved in the glycolytic pathway, it also known as multifunctional protein, since enolases anchored on outer surface of plasma membrane are tissue invasion.We have identified an extracellular (Ae-ENO) produced by teratocytes, embryonic cells insect parasitoid Aphidius ervi. We demonstrate that Ae-ENO, although lacking signal peptide, accumulates cytoplasmic vesicles oriented towards cell membrane. Ae-ENO binds to and activates plasminogen-like...
Gastric cancer (GC) is characterized by poor efficacy and modest clinical impact of current therapies, in which apoptosis evasion relevant. Intracellular calcium homeostasis dysregulation associated with escaping, aberrant expression regulator genes could promote GC drug resistance. Since we previously found a prognostic value for TRPV2 channel GC, aimed to characterize the role cisplatin Using TCGA-STAD dataset, performed differential gene analysis between samples upper lower tertiles...
Background and objective The oncogenic effect of ionizing radiation is widely known. Sarcomas developing after therapy (RT), termed “iatrogenic disease success”, represent a growing problem, since the advancements in cancer management screening programs have increased number long-term survivors. Although many patients been treated with therapy, only few data are available on radiation-induced sarcomas (RIS). Methods We examined medical radiological records 186 histologically proven soft...
Gastric cancer (GC) molecular heterogeneity represents a major determinant for clinical outcomes, and although new classifications have been introduced, they are not easy to translate from bench bedside. We explored the data GC public databases by performing differential gene expression analysis (DEGs) network reconstruction identify master regulators (MRs), as well set (GSA) reveal their biological features. Moreover, we evaluated association of MRs with clinicopathological parameters....
Background: We compared two groups of high-risk patients with abdominal aortic aneurysm to assess the safety and efficacy endovascular repair vs. open surgery. Methods: From January 1998 July 2003, sixty-two were divided into groups: group A consisted 28 (46 %) surgery B 34 (54 who underwent repair. Results: Four (14.3 in died, while no deaths occurred (p < 0.05). There 14 complications 8 versus 2 = 0.01). At follow-up there 4 (16.6 3 (8.8 n. s.). Conclusions: While use are physiologically...