A5081727057- Hydrogels: synthesis, properties, applications
- Polymer Surface Interaction Studies
- Protein purification and stability
- Enzyme Catalysis and Immobilization
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Glycosylation and Glycoproteins Research
- Advanced Polymer Synthesis and Characterization
- Lipid Membrane Structure and Behavior
- Bone Tissue Engineering Materials
- Botanical Research and Applications
- Biomedical Research and Pathophysiology
- Advanced Sensor and Energy Harvesting Materials
- Surface Modification and Superhydrophobicity
- Insect Resistance and Genetics
- Advanced Drug Delivery Systems
- Protein Kinase Regulation and GTPase Signaling
- Supramolecular Self-Assembly in Materials
- Boron Compounds in Chemistry
- Advanced Chemical Sensor Technologies
- Chemical Synthesis and Analysis
Ideon Science Park
2018-2024
Medeon
2018-2024
ITMO University
2023
Vitrolife (Sweden)
2023
Malmö University
2016
Lund University
2001-2009
University of Miyazaki
2006
Russian Academy of Sciences
1991-2003
Plovdiv University
1990-2003
Institute of Bioorganic Chemistry
1990-2002
Abstract Summary: The copolymer of N ‐isopropylacrylamide and 3‐(acrylamido)phenylboronic acid (82:18, $\overline M _{\rm n}$ = 47 000 g · mol −1 ) was prepared by free radical polymerization. showed typical thermal precipitation behavior in aqueous solutions, its temperature ( T P being increased from 23 to 32 °C increasing the pH 6.5 9.7, because ionization phenylboronate units. p K a evaluated as 8.9 ± 0.1 effect on . At > 9, i.e., anionic form copolymer, affected very low...
Conjugation of penicillin acylase (PA) to poly-N-isopropylacrylamide (polyNIPAM) was studied as a way prepare thermosensitive biocatalyst for industrial applications antibiotic synthesis. Condensation PA with the copolymer NIPAM containing active ester groups resulted in higher coupling yields enzyme (37%) compared its chemical modification and copolymerization monomer (9% yield) at same NIPAM:enzyme weight ratio ca. 35. A 10-fold increase loading on 24% yield increased by 4-fold specific...
Cross-linked agarose particles (Sepharose CL-6B) and baker's yeast cells were found to adhere siliceous supports end-grafted with boronate-containing copolymers (BCCs) of N,N-dimethylacrylamide at pH> or =7.5, due boronate interactions surface carbohydrates the cells. These registered both on macroscopic molecular levels: BCCs spontaneously adsorbed gel adsorption increasing pH. Agarose stained Procion Red HE-3B formed stable, monolayer-like structures pH 8.0, whereas 7.0-7.8...
Abstract Boronate‐containing polymer brushes were synthesized by free radical copolymerization of N,N ‐dimethylacrylamide (DMAA) and N ‐acryloyl‐ m ‐phenylboronic acid (NAAPBA) (9:1) on the surface 3‐mercaptopropyl‐silylated glass plates capillaries. The characterized with time‐of‐flight secondary ion mass‐spectrometry (ToF SIMS), atomic force microscopy contact angle measurements. Fructose caused a well‐expressed drop spreading copolymer‐grafted glass, due to strong interaction boronate...
Abstract Interaction of mono‐ and disaccharides, polysaccharide particles yeast cells with boronate‐containing copolymers (BCC) N‐acryloyl‐ m ‐aminophenylboronic acid (NAAPBA) N,N ‐dimethylacrylamide (DMAA) or N‐isopropylacrylamide (NIPAM) was studied. The binding saccharides to BCC NIPAM resulted in a shift its phase transition temperature (ΔT P ), which provided quantitative measure for the complex formation. Among sugars typical non‐reducing ends glycoproteins ΔT decreased order:...
Adsorption of myoglobin (Mb), bovine serum albumin (BSA) and γ-globulin (GG) onto activated carbons (ACs) with different pore size distributions, poly(vinyl alcohol) (PVA) monolithic cryogels containing AC particles was studied. The highest initial rate Mb adsorption observed for having the largest specific surface area (1939 m2 g−1) volume (1.82 cm3 g−1). kinetics proteins characterized by a bimodal shape distribution f(D) function an effective diffusion coefficient. isotherms GG were...
A set of glutaraldehyde (GA) cross-linked poly(vinyl alcohol)/activated carbon (PVA/GA/AC) composites prepared in the form monolithic rods using a cryogelation technique and studied adsorption, mercury porosimetry, scanning electron microscopy (SEM), quantum chemistry methods display porosity similar to that PVA/GA cryogel at high GA content (content ratio GA/AC = 1 GA/PVA 0.2). PVA multilayer coverage is an effective barrier for adsorption on AC particles. Variations surface (AC initial...
Reversible changes of the height a polymer brush containing phenylboronic acid were studied. The thickness underwent reversible 0.5-1 nm, in response to composition contacting aqueous phase from deionized water bicarbonate buffer and vice versa, apparently due conformational transition weak polyelectrolyte more extended electrically charged state. Adsorption mucin glycoprotein took place boronate/sugar interactions between graft copolymer resulted further increase by ca. 1.5 as observed...
Effective technologies are required to remove organic micropollutants from large fluid volumes overcome present and future challenges in water effluent treatment. A novel hierarchical composite filter material for rapid effective removal of polar contaminants was developed. The is fabricated phenolic resin-derived carbon microbeads with controllable porous structure specific surface area embedded a monolithic, flow permeable, poly(vinyl alcohol) cryogel. bead-embedded monolithic retains the...
The copolymer of 3-(acrylamido)phenylboronic acid and N-isopropylacrylamide (82:18, Mn = 47000 g/mol) was prepared by free radical polymerization. showed typical thermoprecipitation behavior in aqueous solutions; its phase transition temperature (TP) 26.5 +/- 0.2 degrees C 0.1 M glycine-NaOH buffer containing NaCl, pH 9.2. Due to specific complex formation the pendant boronates with sugars, TP strongly affected type sugar concentration at Fructose, lactulose, glucose caused largest increase...
Abstract Summary: Copolymers of N ‐acryloyl‐ m ‐aminophenylboronic acid (NAAPBA) with acryamide (AA), , ‐dimethylacrylamide (DMAA), and ‐isopropylacrylamide (NIPAM) were found to adsorb on cross‐linked agarose gel (Sepharose CL‐6B) in the pH range from 7.5–9.2, due specific boronate‐sugar interactions. The molar percentages phenylboronic (PBA) groups boronate‐containing copolymers (BCCs), as estimated by 1 H NMR spectroscopy, 13, 10, 16%, respectively, whereas apparent ionization constants,...
Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response minor changes temperature, pH solvent composition. Grafting these solid surfaces imparts the with controllable wettability and adsorption behaviour. The review summarizes theoretical models results physical measurements conformational transitions grafted polymer chains brushes. Primary attention is paid grafting density length spatial arrangement...
Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS‐DVB) microparticles into macroporous polymer structures produced cryogelation agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow‐through properties. Scanning electron microscopy cryogels revealed that covered thin films alcohol) and thus withheld in monolith structure. Plain PS‐DVB showed efficient adsorption albumin‐bound toxins related to liver failure...