A5103251929- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- IL-33, ST2, and ILC Pathways
- Chromosomal and Genetic Variations
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Plant Molecular Biology Research
- Autophagy in Disease and Therapy
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- Toxoplasma gondii Research Studies
- Misinformation and Its Impacts
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- Calcium signaling and nucleotide metabolism
Chinese Center For Disease Control and Prevention
2023
St. Jude Children's Research Hospital
2016
Texas Tech University
2009
RNA silencing functions as an important antiviral defense mechanism in a broad range of eukaryotes. In plants, biogenesis several classes endogenous small interfering RNAs (siRNAs) requires RNA-dependent Polymerase (RDR) activities. Members the RDR family proteins, including RDR1and RDR6, have also been implicated defense, although direct role for RDRs viral siRNA has yet to be demonstrated. Using crucifer-infecting strain Tobacco Mosaic Virus (TMV-Cg) and Arabidopsis thaliana model system,...
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as negative feedback regulator lysosomal biogenesis autophagy. Mice macrophages lacking activity had increased resistance to the cytosolic bacterial pathogen Francisella novicida. Genetic deletion or pharmacological inhibition down-regulated...
RNA silencing functions as an important antiviral defense mechanism in a broad range of eukaryotes.In plants, biogenesis several classes endogenous small interfering RNAs (siRNAs) requires RNA-dependent Polymerase (RDR) activities.Members the RDR family proteins, including RDR1and RDR6, have also been implicated defense, although direct role for RDRs viral siRNA has yet to be demonstrated.Using crucifer-infecting strain Tobacco Mosaic Virus (TMV-Cg) and Arabidopsis thaliana model system, we...