A5068834494- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Renin-Angiotensin System Studies
- Virus-based gene therapy research
- Enzyme function and inhibition
- Viral gastroenteritis research and epidemiology
- Renal Diseases and Glomerulopathies
Université Paris-Saclay
2018-2022
Institut Gustave Roussy
2018-2022
Sorbonne Paris Cité
2022
Université Paris Cité
2021-2022
Inserm
2018-2022
Centre National de la Recherche Scientifique
2022
Institut Curie
2022
Université Paris Sciences et Lettres
2022
Laboratory of Excellence GR-Ex
2021
The developmental history of blood cancer begins with mutation acquisition and the resulting malignant clone expansion. two most prevalent driver mutations found in myeloproliferative neoplasms— JAK2 V617F CALR m —occur hematopoietic stem cells, which are highly complex to observe vivo. To circumvent this difficulty, we propose a method relying on mathematical modeling statistical inference determine disease initiation dynamics. Our findings suggest that tend occur later life than . results...
Mutant calreticulin (CALR) proteins resulting from a -1/+2 frameshifting mutation of the CALR exon 9 carry novel C-terminal amino acid sequence and drive development myeloproliferative neoplasms (MPNs). CALRs were shown to interact with activate thrombopoietin receptor (TpoR/MPL) in same cell. We report that mutant are secreted can be found patient plasma at levels up 160 ng/mL, mean 25.64 ng/mL. Plasma is complex soluble transferrin 1 (sTFR1) acts as carrier protein increases half-life....
Current murine models of myeloproliferative neoplasms (MPNs) cannot examine how MPNs progress from a single bone marrow source to the entire hematopoietic system. Thus, using transplantation knock-in JAK2V617F cells into irradiated leg, we show development polycythemia vera (PV) anatomic site in immunocompetent mice. Barcode experiments reveal that grafted stem/progenitor migrate leg nonirradiated organs such as contralateral and spleen, which is strictly required for PV. Mutant colonizing...
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