A5080947792- Parasitic Diseases Research and Treatment
- Parasite Biology and Host Interactions
- Mosquito-borne diseases and control
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Insects and Parasite Interactions
- Parasites and Host Interactions
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Hepatitis B Virus Studies
- Malaria Research and Control
- Insect Utilization and Effects
- RNA and protein synthesis mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Healthcare Policy and Management
- Viral Infections and Vectors
- Pancreatic function and diabetes
- Trypanosoma species research and implications
- Zoonotic diseases and public health
- CRISPR and Genetic Engineering
- Diversity and Career in Medicine
- Evolution and Genetic Dynamics
- Helminth infection and control
- Insect symbiosis and bacterial influences
Taylor and Francis (United Kingdom)
2015-2025
Carter Center
2013-2024
OSE Immunotherapeutics (France)
2022
University of Chicago
2022
Vanderbilt University
2022
The Carter Center
2019-2021
Max Perutz Labs
2014-2020
University of Vienna
2014-2020
Pacific Environment
2014
Pace University
2012
Dracunculiasis was rediscovered in Chad 2010 after an apparent absence of 10 years. In April 2012 active village-based surveillance initiated to determine where, when, and how transmission the disease occurring, implement interventions interrupt it. The current epidemiologic pattern is unlike that seen previously or other endemic countries, i.e., no clustering cases by village association with a common water source, average number worms per person small, large dogs were found be infected....
Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is acquired drinking water containing small crustacean copepods (water fleas) infected with D. medinensis larvae. Recent evidence suggests that also appears to be transmitted eating fish or other aquatic animals. About 1 year after infection, typically emerges through skin on a lower limb of host, causing pain and disability (1). No vaccine medicine available prevent treat dracunculiasis. Eradication relies...
Whole genome sequencing is being rapidly applied to the study of helminth genomes, including de novo assembly, population genetics, and diagnostic applications. Although late-stage juvenile adult parasites typically produce sufficient DNA for molecular analyses, these parasitic stages are almost always inaccessible in live host; immature life found environment which samples can be collected non-invasively offer a potential alternative, however, yield very low quantities DNA, environmentally...
This report summarizes the status of global Dracunculiasis Eradication Program as end 2017. (guinea worm disease) has been eliminated from 19 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide. Only Chad and Ethiopia reported humans, 15 each, Infections animals, mostly domestic dogs, with Dracunculus medinensis were those two also Mali. Insecurity infections animals are main obstacles remaining to interrupting dracunculiasis transmission completely.
Background Guinea worm– Dracunculus medinensis– was historically one of the major parasites humans and has been known since antiquity. Now, worm is on brink eradication, as efforts to interrupt transmission have reduced annual burden disease from millions infections per year in 1980s only 54 human cases reported globally 2019. Despite enormous success eradication date, complication arisen. Over last few years, hundreds dogs found infected with this previously apparently anthroponotic...
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after person acquires infection from contaminated drinking water, the emerges through skin, usually on lower limb (1). Pain and secondary bacterial can cause temporary or permanent disability that disrupts work schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, World Health Assembly called for elimination,* global Guinea Worm Eradication...
After a ten-year absence of reported Guinea worm disease in Chad, human cases were rediscovered 2010, and canine first recorded 2012. In response, active surveillance for both humans animals was re-initiated As 2018, the Chad Worm Eradication Program (CGWEP) maintains an extensive system that operates 1,895 villages, collects information about worms, hosts (animals humans), animal owners. This report describes detail CGWEP explores epidemiological trends during 2015–2018. Our results showed...
Abstract Aim To determine whether hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels impact glucagon‐like peptide‐1 (GLP‐1) receptor (GLP‐1R) modulation of islet Ca 2+ handling and insulin secretion. Methods The liraglutide (GLP‐1 analogue) on handling, HCN currents secretion was monitored with fluorescence microscopy, electrophysiology enzyme immunoassays, respectively. Furthermore, liraglutide‐mediated β‐to‐δ‐cell cross‐communication assessed following selective ablation...
With only 30 dracunculiasis cases in humans reported 2017, the goal of eradicating Guinea worm disease appears to be on horizon. However, infections dogs and insecurity Mali South Sudan remain challenges eradication efforts.
Dracunculus medinensis (Guinea worm [GW]), a zoonotic nematode targeted for eradication, has been managed using interventions aimed at humans; however, increases in domestic dog GW infections highlight the need novel approaches. We conducted two clinical trials evaluating efficacy of subcutaneously injected flubendazole (FBZ) as treatment infection. The first trial was administering FBZ to experimentally infected ferrets; second involved or placebo dogs Republic Tchad (Chad). found...
Conflict and violence constitute threats to public health. As levels of conflict increase within between countries, it is important explore how resolution initiatives can be adapted meet the health needs communities, addressing communities assist in contribute security. In conflict-affected central Mali, a Peace through Health Initiative, piloted 2018 2022, used trainings, facilitated community meetings, human animal interventions negotiate "periods tranquility" achieve goals. Project...
This report summarizes the status of global Dracunculiasis Eradication Program as end 2012. (Guinea worm disease) has been eliminated from 17 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide. Only 542 were reported four 2012, and 103 villages still had indigenous transmission. Most remaining new Republic South Sudan, whereas Chad, Ethiopia, Mali each 10 or less. Political instability insecurity may become main obstacles to interrupting...
The human genome is scattered with repetitive sequences, and the ENCODE project revealed that 60–70% of genomic DNA transcribed into RNA . As a consequence, transcriptome contains large portion repeat‐derived RNAs ( repRNAs ). Here, we present hypothesis for evolution novel functional from non‐coding ncRNAs ) by retrotransposition. Upon amplification, can diversify in sequence subsequently evolve new activities, which result functions. Non‐coding transcripts derived highly regions therefore...
Dracunculiasis (Guinea worm disease) is caused by the parasite Dracunculus medinensis and acquired drinking water containing copepods (water fleas) infected with D. larvae. The typically emerges through skin on a lower limb approximately 1 year after infection, resulting in pain disability (1). There no vaccine or medicine to treat disease; eradication efforts rely case containment* prevent contamination. Other interventions infection include health education, filtration, chemical treatment...
This report summarizes the status of global Dracunculiasis Eradication Program as end 2021. (Guinea worm disease) has been eliminated from 17 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide. Only Chad, Ethiopia, Mali, and South Sudan reported humans Mali also indigenous infections animals, mostly domestic dogs, with Dracunculus medinensis. Insecurity animals are main obstacles remaining to interrupting dracunculiasis transmission completely.