A5004617842- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Malaria Research and Control
- Child Nutrition and Water Access
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Health, Environment, Cognitive Aging
- Heart Rate Variability and Autonomic Control
- Legionella and Acanthamoeba research
- HIV/AIDS Research and Interventions
- Sex work and related issues
- Parasites and Host Interactions
- Travel-related health issues
- Hepatitis B Virus Studies
- Lipid Membrane Structure and Behavior
- Virology and Viral Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Extracellular vesicles in disease
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Nanopore and Nanochannel Transport Studies
- Invertebrate Immune Response Mechanisms
- Syphilis Diagnosis and Treatment
University of Coimbra
2016-2024
Escola Universitária Vasco da Gama
2024
University of Lisbon
2024
Hospitais da Universidade de Coimbra
2023
Fundação Oswaldo Cruz
2003-2017
Background Intestinal parasitic infections remain among the most common infectious diseases worldwide. This study aimed to estimate their prevalence and provide a detailed analysis of geographical distribution intestinal parasites in metropolitan region Rio de Janeiro, considering demographic, socio-economic, epidemiological contextual factors. Methods/Principal findings The cross-section survey was conducted individuals attending Evandro Chagas National Institute Infectious Diseases...
Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur (SO2) has been suggested contribute the etiology Autism Spectrum Disorder (ASD). In this study, we used quality monitoring data examine whether mothers children with ASD were exposed high levels pollutants during critical periods pregnancy, if higher may lead a clinical severity in their offspring. We public from Portuguese...
Background Despite the high prevalence of giardiasis, genetic characterization Giardia lamblia has been poorly documented in Brazil and molecular epidemiology research only conducted last few years. The aim this study was to determine different G. assemblages detect mixed infections among patients with giardiasis. Methods Principal Findings cross-section survey attending FIOCRUZ Rio de Janeiro. In order discriminate assemblages/sub-assemblages, isolates were characterized by PCR-RFLP qPCR...
Foodborne outbreaks are often associated with the consumption of salads. However, published studies on detection foodborne pathogens in ready-to-eat salads scarce. The aim this study was to detect Giardia duodenalis and Cryptosporidium DNA salads, by applying techniques molecular biology frequency contamination A total 100 packages containing assorted leafy green vegetables were randomly purchased from hypermarkets located central regions Portugal (Coimbra Viseu). Nested-PCR qPCR methods...
Abstract The protozoan Giardia lamblia is the most common cause of parasitic gastrointestinal infection worldwide. parasite developed sophisticated, yet not completely disclosed, mechanisms to escape immune system and growth in intestine. To further understand interaction G. with host cells, we investigated ability parasites modulate canonical activation mouse macrophages (Raw 264.7 cell line) human monocyte-derived triggered by TLR4 agonist, lipopolysaccharide (LPS). We observed that...
We report a study on toxoplasmosis in pregnant women Luanda, Angola, determining the seroprevalence, geospatial distribution and its association with socio-economic features, dietary habits hygiene health conditions. Anti- Toxoplasma gondii IgG IgM were quantified serum samples of attended at Lucrecia Paim Maternity Hospital between May 2016 August 2017. The avidity test qPCR assay used for dating primary infection. Data collected by questionnaire after written consent, spatial was assessed...
Abstract Background HIV and HBV infections remain responsible for high rate of morbidity mortality in many African Countries, affecting women newborns. This study aims to analyze the spatial pattern pregnant Luanda, Angola, statistical association between socio-economic characteristics, hygiene, health status. Methods Detection anti-HIV antibodies (total anti-HIV-1, anti-HIV-2 HIV-1 p24 antigen) Hepatitis B antigens (HBsAg, HBeAg) (anti-HBc Total II, HBc IgM, Anti-HBsT II) was performed by...
Abstract The present work evaluated the surveillance of drinking water quality information system database and correlated findings microbiological analysis with distribution intestinal protozoa from metropolitan region Rio de Janeiro. From database, we obtained 1,654 georeferenced monitoring stations that were used in analysis. results indicate minimum number samples collected per parameter (free residual chlorine, turbidity, counts total fecal coliforms (Escherichia coli)) was not...
Extracellular vesicles (EVs) (exossomes, microvesicles and apoptotic bodies) have been well acknowledged as mediators of intercellular communications in prokaryotes eukaryotes. Lipids are essential molecular components EVs but at the moment knowledge about lipid composition function lipids is limited for now none lipidomic studies Giardia was described. Therefore, focus current study to conduct, first time, characterization polar lipidome, namely phospholipid sphingolipid profiles G. lamblia...
In this study, we investigated the role of Giardia EVs in cellular communication and their potential as vaccine candidates. Our findings revealed that activate pro-inflammatory signalling cascades, including SAPK/JNK ERK1/ERK2, well NF-kB pathway, resulting IκB-α degradation p65 translocation to nucleus, mouse macrophages. Moreover, increased expression genes encoding molecules, such Il1β, Il6, Il4, Ptgs2, Nos2, Tnf. Interestingly, enhanced maturation status human Mo-DCs significantly T-cell...
The antibody response to Plasmodium falciparum parasites of naturally infected population is critical elucidate the role polymorphic alleles in malaria. Thus, we evaluated impact antigenic diversity repetitive and family dimorphic domains merozoite surface protein 2 (MSP-2) on immune 96 individuals living Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. majority these were carrying FC27-type infections. IgG responses predominantly directed FC27 correlated extension...
Both CMV and Rubella virus infections are associated with the risk of vertical transmission, fetal death or congenital malformations. In Angola, there no reports studies. Therefore, our objectives were to study seroprevalence anti-CMV anti-Rubella antibodies in pregnant women Luanda (Angola), identify primary infection during pregnancy evaluate socio-demographic factors both infections.
Exercise-based cardiac rehabilitation programs (CRPs) represent a multidisciplinary therapeutic approach tailored to improve cardiorespiratory fitness and overall health-related quality of life, while reducing cardiovascular hospitalizations mortality. Our aim was determine changes in exercise capacity events according the left ventricular ejection fraction (LVEF) following CRP.
Abstract Background: The main objective was to study the seroprevalence of anti-CMV and anti-Rubella antibodies in pregnant women Luanda (Angola), identify primary maternal infection during gestation evaluate socio-demographic risk factors associated with CMV Rubella virus infections. Methods: A prospective cross-sectional conducted from August 2016 May 2017. Blood samples were collected specific (IgG IgM) quantified by electrochemiluminescence (COBAS e411). Demographic clinical data...