A5048983541- Pain Mechanisms and Treatments
- Diabetes Treatment and Management
- Diabetes Management and Research
- Sinusitis and nasal conditions
- Geography Education and Pedagogy
- Antifungal resistance and susceptibility
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Spatial Cognition and Navigation
- Metabolism, Diabetes, and Cancer
- Anesthesia and Pain Management
- Spinal Dysraphism and Malformations
- Virtual Reality Applications and Impacts
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatic function and diabetes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Educational Environments and Student Outcomes
- Sirtuins and Resveratrol in Medicine
- Infectious Diseases and Tuberculosis
- Cerebrospinal fluid and hydrocephalus
- Endodontics and Root Canal Treatments
- Acupuncture Treatment Research Studies
- Musculoskeletal pain and rehabilitation
- Phytochemicals and Antioxidant Activities
University College of Medical Sciences
2024
Guru Teg Bahadur Hospital
2024
Eli Lilly (United States)
1999-2022
University of Maryland, Baltimore
2020-2022
Massachusetts General Hospital
2019-2020
Harvard University
2020
Oregon State University
2020
Wake Forest University
2015-2018
University of Nebraska at Omaha
2014-2017
Panjab University
2010-2014
Background And AimsEndoscopic disease activity scoring in ulcerative colitis (UC) is useful clinical practice but done infrequently. It required trials, where it expensive and slow because human central readers are needed. A machine learning algorithm automating the process could elevate care facilitate research. Prior work using single-institution databases endoscopic still images has been promising.MethodsSeven hundred ninety-five full-length endoscopy videos were prospectively collected...
Interleukin-23 inhibitors are effective and safe for treating moderate-to-severe plaque psoriasis.To evaluate the efficacy safety of mirikizumab in adult patients with psoriasis through 52 weeks a phase III randomized controlled trial.OASIS-1 (NCT03482011) was double-blind, placebo-controlled, withdrawal, trial. Patients (n = 530, 4 : 1) received subcutaneous 250 mg or placebo every (Q4W) week 16. Coprimary endpoints were superiority vs. on static Physician's Global Assessment (sPGA; score 0...
OBJECTIVE: Humalog Mix25 is a manufactured premixed insulin formulation containing lispro and novel lispro-protamine (NPL) in ratio of 25:75%. The objective this study was to compare human 30/70 (30% regular insulin/70% NPH) with respect glycemic control. RESEARCH DESIGN AND METHODS: compared 89 individuals type 2 diabetes during 6-month randomized open-label two-period crossover study. Each administered twice daily, before the morning evening meals. Information regarding self-monitored...
Abstract Trigeminal neuropathic pain (TNP) is often resistant to current pharmacotherapy, and there a pressing need develop more efficacious treatments. Capsaicin pungent ingredient of chili peppers specifically activates transient receptor potential vanilloid subtype 1 (TRPV1), Ca 2+ -permeable ion channel. Topical capsaicin invariably induces burning pain. Paradoxically, the followed by prolonged attenuation preexisting pathologic from same region. However, mechanisms underlying...
Capsaicin is a specific agonist of transient receptor potential vanilloid 1 (TRPV1), which enriched in nociceptors. not only produces acute pain but also leads to long-lasting analgesia patients with chronic pain. Although capsaicin-induced TRPV1 and Ca 2+ /calpain-dependent ablation axonal terminals necessary for analgesia, the mechanisms underlying its association are fully understood. Microtubules composed tubulin polymers serve as main cytoskeleton maintaining integrity. In this study,...
Chronic fatigue syndrome (CFS) is a specific clinical condition that characterizes unexplained disabling fatigue. In the present study, chronic was produced in mice by subjecting them to forced swim inside rectangular jar of dimensions for 6 min. daily 15 days. Epigallocatechin gallate (EGCG; 25, 50 and 100 mg/kg, p.o.) administered 30 before session. Immobility period post-swim assessed on alternate On 16th day, after assessment various behavioural parameters, were killed harvest brain,...
Abstract Although degenerative disc disease (DDD) and related low back pain (LBP) are growing public health problems, the underlying mechanisms remain unclear. An increase in vascular endothelial growth factor (VEGF) levels DDD has been reported. This study aimed to examine role of VEGF receptors (VEGFRs) DDD, using a mouse model DDD. Progressive was induced by anterior stabbing lumbar intervertebral discs wild type (WT) VEGFR‐1 tyrosine‐kinase deficient mice ( vegfr‐1 TK−/ − ). Pain...
Periodontitis is a highly prevalent chronic inflammatory disease that progressively destroys the structures supporting teeth, leading to tooth loss. Periodontal tissue innervated by abundant pain-sensing primary afferents expressing neuropeptides and transient receptor potential vanilloid 1 (TRPV1). However, roles of nociceptive nerves in periodontitis bone destruction are controversial. The placement ligature around maxillary second molar or oral inoculation pathogenic bacteria induced...
In the United States, fentanyl causes approximately 60,000 drug overdose deaths each year. Fentanyl is also frequently administered as an analgesic in perioperative setting, where respiratory depression remains a common clinical problem. Naloxone efficacious opioid antagonist, but it possesses short half-life and undesirable side effects. This study was conducted to test hypothesis that d-amphetamine ameliorates hastens return of consciousness following high-dose fentanyl. Behavioral...
Chronic unpredictable stressors can produce a situation similar to clinical depression and such animal models be used for the preclinical evaluation of antidepressants. Nitric oxide, secondary messenger molecule, has been implicated in neurotransmission, synaptic plasticity, learning, aggression depression. Vaccinium myrtillus (bilberry) extract is potent inhibitor reactive oxygen/nitrogen species cytokine production. The present study investigated role nitric oxide antidepressant action...
J Clin Hypertens (Greenwich). Type 2 diabetes mellitus (T2DM) treatment should not increase cardiovascular (CV) risk and at best could provide benefit beyond lowering glucose. Pioglitazone has demonstrated a favorable CV profile relative to other oral antidiabetic drugs (OADs) in outcome observational studies. This randomized, double‐blind, parallel‐group controlled study examined circulating biomarkers of T2DM patients receiving fixed‐dose combination (FDC) pioglitazone/metformin compared...
A total of 166 patients (102 type 1, 64 2) were randomised to insulin lispro (LP) combined with protamine suspension (NPL), an intermediate-acting formulation LP, or regular human (HR) NPH (NPH) in this open-label, parallel study. Insulin doses similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) lower LP/NPL breakfast (8.84 +/- 0.32 vs 10.29 0.41, p < 0.001), before lunch (6.21 0.20 7.10 0.31, = 0.016), the evening meal (10.18 0.36...