A5045269985- Carcinogens and Genotoxicity Assessment
- Vitamin C and Antioxidants Research
- Vitamin D Research Studies
- Cannabis and Cannabinoid Research
- Phytochemistry and Bioactive Compounds
- Vitamin K Research Studies
- Probiotics and Fermented Foods
- Biochemical Analysis and Sensing Techniques
- Fungal Biology and Applications
- Clostridium difficile and Clostridium perfringens research
- Aquaculture disease management and microbiota
- Chemical Synthesis and Analysis
- Pesticide Exposure and Toxicity
- Carbohydrate Chemistry and Synthesis
- Toxin Mechanisms and Immunotoxins
- Bioactive natural compounds
- Acute Lymphoblastic Leukemia research
- Gut microbiota and health
- Tea Polyphenols and Effects
American Institute of Biological Sciences
2016-2018
A battery of toxicological studies was conducted on a supercritical CO 2 extract the aerial parts Cannabis sativa plant, containing approximately 25% cannabinoids. No evidence genotoxicity found in bacterial reverse mutation test (Ames), an vitro mammalian chromosomal aberration test, or vivo mouse micronucleus study. 14-day repeated oral dose-range finding study Wistar rats at 1000, 2000, and 4000 mg/kg bw/day resulted effects where NOAEL could not be concluded. Based those results, 90-day...
Morus alba L. (white mulberry) leaves are one of the oldest recognized traditional Chinese medicines. More recently, M and their constituents, particularly iminosugars (or azasugars), have garnered attention for ability to maintain normal blood glucose concentrations, an effect identified in both animal studies human clinical trials. Reducose (Phynova Group Limited) is a commercial water-soluble extract standardized 5% 1-deoxynojirimycin (DNJ), iminosugar with α-glucosidase inhibition...
A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses 0 (vehicle only), 180, 300, 375 mg/kg bw/day. Two females one male 300 bw/day groups, respectively, died during study. Histological examination revealed centrilobular hepatocellular necrosis as probable...
This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, repeated dose oral toxicity study, and developmental study rats. No evidence mutagenicity or clastogenicity surfaced studies at concentrations up to 5000 μg extract/plate (Ames test) extract/mL (chromosomal aberration test). deaths treatment-related were seen...