The temperature and rainfall trends are analysed for meteorological data of Labandi station, Raipur district in Chhattisgarh, India over approximately last three decades stretching between years 1971 to 2013. long–term change has been assessed by linear trend analysis. increasing mean maximum (MMAX) total (TMRF) is confirmed Mann-Kendall test. It observed that Chhattisgarh region, the December MMAX increased 1.1008 0C annual 0.0256 whereas highest decrease TMRF occurs August @ 1.4385 mm per...

Bitter orange (Citrus aurantium L.) extracts are widely used in dietary supplements and bitter oranges various juices food products. p-Synephrine, the primary active constituent, comprises approximately 90% of total protoalkaloids. This study, performed per OECD 408 guidance, examined 90-day subchronic safety/toxicity an extract standardized to 50% p-synephrine at doses 100, 300 1000 mg/kg/day male female rats. No adverse effects were observed with respect any parameters clinical signs,...

Silk fibroin (SF) is a natural biocompatible protein polymer extracted from cocoons of silkworm Bombyx mori. SF can be processed into variety different forms and shapes that used as scaffolds to support bone regeneration. Three-dimensional (3D) have shown promise in bone-void-filling applications. In vitro studies, it has been demonstrated microparticle-based (M-RSF) scaffold promotes the differentiation stem cells an osteoblastic lineage. The expression markers was also significantly higher...

(-)-Hydroxycitric acid (HCA), active constituent (10%–30%) of the dried fruit rind Garcinia cambogia, is commonly used as a dietary supplement for weight management. The objective present study was to evaluate teratogenic potential novel calcium/potassium salt HCA (HCA-SX) in Sprague-Dawley rats. Due its affect fat synthesis and reduce food intake, processes that are often crucial normal fetal development, this teratology undertaken part multigeneration reproductive investigation. animals...

(-)-Hydroxycitric acid (HCA), a natural plant extract from the dried fruit rind of Garcinia cambogia, has been reported to inhibit fat synthesis and reduce food intake. The objective this study was evaluate effects novel calcium/potassium salt (-)-hydroxycitric (HCA-SX) on reproductive systems male female rats, postnatal maturation capacity their offspring, possible cumulative through multiple generations. Sprague-Dawley rats (30/sex/group) were maintained feed containing HCA-SX at dose...

Momordica charantia plant is consumed as a foodstuff in some south Asian curries while its extract preparations have been traditionally used for lowering blood glucose levels patients with diabetes mellitus. Nutritional Health Institute Laboratories (NHIL), LLC, Florida informed that it patented new McB, an interhybrid of three plants genus. The objective the present study was to investigate potential adverse effects, if any, McB-E60 (extract sp.) rats following subchronic administration....

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, repeated dose oral toxicity study, and developmental study rats. No evidence mutagenicity or clastogenicity surfaced studies at concentrations up to 5000 μg extract/plate (Ames test) extract/mL (chromosomal aberration test). deaths treatment-related were seen...

Background: Citrus sudachi, an evergreen tree found primarily in the prefecture of Tokushima, Japan, is a widely used popular citrus fruit cooking and also consumed as juice. sudachi peels are rich flavonoids including sudachitin (5,7,4’-trihydroxy-6,8,3’-trimethoxyflavone), exhibit potent antioxidant, antimicrobial anti-diabetic properties, while several limonoids their glucosides its seeds. We examined broad spectrum safety novel light yellow to golden Extract Powder (organic, nutritive)...

Palmitoylethanolamide (PEA) is an endogenous ethanolamine playing a protective and homeodynamic role in animals plants. Prenatal developmental toxicity of PEA was tested following oral administration to pregnant female Wistar rats, from days 0 19 gestation, at dosage 250, 500, or 1,000 mg/kg body weight, according Organisation for Economic Co-operation Development Test Guideline No. 414. On gestation day 20, cesarean sections were performed on the dams, followed by examination their ovaries...

Pyrroloquinoline quinone (PQQ), a potent coenzyme antioxidant naturally occurring in foods, has been demonstrated to protect brain cells by enhancing the expression of nerve growth factors (NGF) and NGF receptors, suppressing fibril formation aggression amyloid β. We developed mnemoPQQ®, novel PQQ disodium salt assessed its safety GLP compliant toxicity studies. Acute studies mnemoPQQ® Wistar rats revealed that LD50 was 1825- 1410 mg/kg body weight (bw) male female rats, respectively,...

Studies have indicated that teachers are not efficiently trained in the use of technology. Though various learning technologies become available schools, using them for instructional purposes. Hence researchers developed a programme improving knowledge Technological Pedagogical Content Knowledge (TPACK) pre-service college education Maharashtra, India. The purpose this study was to conduct an experimental TPACK intervention updating teachers. employed single group pre-training and...

Critical thinking is widely considered a vital aspect of education, necessary for comprehending concepts and solving problems. Compelling evidence from various studies indicates that even significant number university graduates lack the ability to think critically, despite its emphasis in education. involves process reasoning reasonable, reflective, aimed

<div>Infection with SARS-CoV-2 has resulted in COVID-19 pandemic and infected more than 5</div><div>million individuals around 0.35 million deaths worldwide till May 2020 end. Several</div><div>efforts are on search of therapeutic interventions, but the preferred way is drug</div><div>repurposing due to feasibility urgency situation. To select prioritize</div><div>approved antiviral drugs drug combinations for COVID-19, 61...