This study was performed to test the existing notion that an increased muscle sympathetic nerve discharge is part of underlying mechanism for chronic pain syndrome primary fibromyalgia. Muscle activity recorded in peroneal eight patients with fibromyalgia and age-matched controls. No difference baseline observed between Furthermore, did not show exaggerated responses static handgrip or jaw contractions, postcontraction ischemia mental stress. Thus results do indicate overactivity...

In 11 female patients with Fibromyalgia Syndrome (FS), biopsies from the m. vastus lateralis were analyzed, in order to reveal any possible changes which might explain muscular weakness and fatigue. Nineteen healthy subjects served as a control group. Light microscopy did not show gross histopathological findings. Fiber composition fiber areas differ between two groups, except for greater coefficient of variation area type II A fibers mean FS The number capillaries per square millimeter also...

Background Laparoscopic cholecystectomy is presumed to induce a reduction in diaphragmatic activity. Indirect indices of function based on tidal changes pressures and cross-section area measurements can be unreliable the postoperative phase. The present study evaluates activity by directly recording EMG (EMGdia) data, along with indirect indices. Methods Thirteen adult patients (American Society Anesthesiologists physical status I or II) undergoing laparoscopic were examined preoperatively...

Normal pigs, crossbreeds of Swedish Landrace and Yorkshire, about 6 months old, were subjected to experimental stress, induced by the myorelaxant succinylcholine, for 12 min. Besides one group control pigs pretreated with atocopherol (vitamin E) combined selenium (Tokosel Vet®) injected i.m. every second day 11 days, another was given zinc (ZnSO 4.7 H 2 O) in fodder 1 month plus injection i.p. days before stress. The stress‐induced heart lesions, morphologically graded according evaluation...

We previously investigated the inactivation of endothelin-1 by deamidase (lysosomal protective protein), present in many cells, including vascular smooth muscle cells. This enzyme, which we originally purified from human platelets, preferentially hydrolyzes peptides at C-terminus with hydrophobic amino acids P1 or P1' position both and thereby inactivates endothelin-1, has a C-terminal sequence Ile19-Ile20-Trp21-OH. tested for presence cultured bovine aortic endothelial The final supernatant...

Thirty-six patients (31 females and 5 males) with "chronic primary fibromyalgia" combined dysesthesia were studied using neuroaudiological tests. Auditory brainstem response (ABR) was pathological in 11 (31%). In six instances the I-V interpeak latency (IPL) prolonged, two interaural difference of wave V (IT5) pathological, three there a reduction amplitude V. A comparison IPLs between female patient group matching control showed that significant prolongation this parameter group. The...

Measurements of regional cerebral blood flow (rCBF), analysis cerebrospinal fluid, auditory brain stem responses (ABR) and oculomotor tests were performed in 19 patients with fibromyalgia. The results from the rCBF measurements showed a normal level slight but significant focal decreases dorsolateral frontal cortical areas both hemispheres. ABR signs dysfunction at least high frequency pathology. fluid discrete changes cell differential count. Possible explanations for involvement central...

Abstract. Objectives . The aim of the investigations was to study effect a combined selenium and vitamin E treatment in patients with myotonic dystrophy. Design A double‐blind placebo‐controlled trial. Subjects Twenty‐seven dystrophy divided into an experimental ( n = 13) control 14) group. Interventions group given increasing doses for 4 months up maximum 1.6 mg 800 daily corresponding number placebo tablets. total period 2 years. Main outcome measures Muscle strength (knee extension, knee...

Abstract Caidahl K, Lurie M, Bake B, Johansson G, Wetterqvist H, (Departments of Clinical Physiology and Medical Rehabilitation, Sahlgren's University Hospital, Gothenburg, Sweden). Dyspnoea in chronic primary fibromyalgia. We investigated the prevalence dyspnoea, according to a 5‐grade score proposed by World Health Organization (WHO), among 87 consecutive women (age 44.0 ± 8.4, range 26–65 years), with severe fibromyalgia (CPF). In total 73 (84%) were dyspnoeic, 47, 17, six four patients...

The endothelin (ET) system is involved in the regulation of myocardial function health as well several diseases, such congestive heart failure, infarction, and septic depression. Conflicting results have been reported regarding acute contractile properties ET-1. We therefore investigated effects intracoronary infusions ET-1 selective ET(B) receptor-selective agonist sarafotoxin 6c with increasing doses anesthetized pigs. Myocardial were measured through analysis left ventricular...

Postoperative negative behavioral changes (NBCs) are common among children, but risk for this is thought to be reduced with premedication. Midazolam has many years been a standard premedication children. More recently, the alpha-2 adrenergic agonist clonidine also become popular as preanesthetic sedative. We hypothesized that was superior midazolam limiting new NBCs in children assessed using Post Hospital Behavior Questionnaire (PHBQ).This prospective, randomized, controlled, blinded study,...

Tissue-type plasminogen activator (t-PA) is the key factor in initiating endogenous fibrinolysis vascular compartment. Regulated release of t-PA from endothelial stores rapidly induced by several humoral factors as well coagulation activation products. The aim present study was to test hypothesis that regional myocardial ischemia induces regulated coronary vasculature vivo.Healthy anesthetized (pentobarbital) pigs (n=8) were studied before and after a 10-min left anterior descending region...

Pigs, crossbreeds of Swedish Landrace and Yorkshire, females castrated males about 6 months old, were exposed to experimental stress. The pigs either considered normal or shown be susceptible develop malignant hyperthermia when tested with halothane at weeks age (stress-susceptible pigs). stress was the restraint type, produced by two different myorelaxant agents, depolarizing succinylcholine non-depolarizing pancuronium. blood levels catecholamines (CA) noradrenaline (NA) adrenaline (A)...

Abstract: The degree of myocardial cell necroses in pigs exposed to stress induced by a myorelaxant (succinylcholine) for about 12 min. was investigated. β‐adrenoceptor blocker propranolol given varying doses prior the stress. these evaluated according point scale, ranging from 0 6 points, and compared with changes found untreated controls following blood levels noradrenaline adrenaline were assayed before, during, immediately after period No protective effect on cardiac lesions when drug...

Abstract. Patients with myotonic dystrophy classified clinically into function groups were studied. Muscle strength for knee extension and flexion was, few exceptions, moderately or markedly reduced successively more severe clinical disability. The reduction in maximal walking speed showed a similar tendency. There was large percentage of both type I relation to normal findings II C fibers biopsies from most patients. fiber area varied greatly even the patients best groups, some whom had...

Background: Reduced gut perfusion is associated with multiple organ failure. Positive end‐expiratory pressure (PEEP) reduces cardiac output (CO) and portal blood flow, might be detrimental in a situation of already compromised intestinal circulation. The aim this study was to investigate regional circulatory metabolic effects PEEP during graded hypoperfusion. Methods: In 12 barbiturate‐anesthetized pigs, we measured systemic flows (superior mesenteric arterial, Q SMA venous, PORT ), jejunal...