A5011378603- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Nonmelanoma Skin Cancer Studies
- Underwater Vehicles and Communication Systems
- Quantum Chromodynamics and Particle Interactions
- Water Quality Monitoring Technologies
- High-Energy Particle Collisions Research
- Atrial Fibrillation Management and Outcomes
- Fish Ecology and Management Studies
- Identification and Quantification in Food
- Advanced Chemical Sensor Technologies
- Fault Detection and Control Systems
- Pulsars and Gravitational Waves Research
- Thermography and Photoacoustic Techniques
- Cardiac Arrhythmias and Treatments
- Structural Engineering and Vibration Analysis
- melanin and skin pigmentation
- Advanced Memory and Neural Computing
- Retinoids in leukemia and cellular processes
- Ear and Head Tumors
- Particle physics theoretical and experimental studies
- Acoustic Wave Phenomena Research
- Venous Thromboembolism Diagnosis and Management
- Salivary Gland Tumors Diagnosis and Treatment
- Structural Health Monitoring Techniques
Yonsei University
2010-2024
University of California, San Diego
2024
Hospital Clínico San Carlos
2023
Rush University Medical Center
2023
University of Washington
2022
Chonnam National University
2007-2022
Roche (Canada)
2020
Griffith University
2017
University of Auckland
2017
Gwangju University
2014
Baseline correction methods based on penalized least squares are successfully applied to various spectral analyses. The change the weights iteratively by estimating a baseline. If signal is below previously fitted baseline, large weight given. On other hand, no or small given when above baseline as it could be assumed part of peak. As noise distributed well however, desirable give same similar in either case. For purpose, we propose new weighting scheme generalized logistic function....
Patients with refractory or relapsed acute myeloid leukemia (R/R AML) have a poor prognosis, high unmet medical need. Idasanutlin is small-molecule inhibitor of MDM2, negative regulator tumor suppressor p53. By preventing the p53-MDM2 interaction, idasanutlin allows for p53 activation, particularly in patients TP53 wild-type (WT) status. MIRROS (NCT02545283) randomized Phase III trial evaluating + cytarabine versus placebo R/R AML. The primary end point overall survival TP53-WT population....
Most spectral data, such as those obtained via infrared, Raman, and mass spectroscopy, have baseline drifts due to fluorescence or other reasons, which an adverse impact on subsequent analyses. Therefore, several researchers proposed the use of various baseline-correction methods address aforementioned issue. However, most require manual adjustment parameters achieve desirable performance. In this study, we propose a method based deep-learning model that combines ResNet UNet. The uses...
Abstract In this paper, we consider a new background elimination method for Raman spectra. As is usually slowly varying with respect to wavelength, it could be approximated by curve. However, the usual curve‐fitting cannot applied because there constraint that estimated must beneath measured spectrum. To meet requirement, adopt polynomial as an approximating function and show estimation converted linear programming problem which special case of constrained optimization. addition, present...
In this paper, we consider a novel method for identification of Raman spectra recorded on different instruments with wavelengths.
Recently, the development of methods for identification explosive materials that are faster, more sensitive, easier to use, and cost-effective has become a very important issue homeland security counter-terrorism applications. However, limited applicability several analytical such as, incapability detecting explosives in sealed container, portability instruments, false alarms due inherent lack selectivity, have motivated increased interest application Raman spectroscopy rapid detection...
The recognition capability of the identification system using Raman spectroscopy is increasing with demands in field. Among various approaches that determine identity a target, signal correlation moving window one most effective and intuitive methods. In this paper, we report new method robust to spectral intensity variations. Using peak distribution given spectrum, adaptively determines meaningful regions for target. Three commercial spectrometer 14 033 library were included study, which...
Many consumer Internet Things (IoT) devices involve spatial sensors such as cameras and microphones. These affect the privacy of nearby people. A prime example is smart home security cameras. We present our work developing scenarios, use cases, design proposals for addressing camera privacy. Preliminary findings from a concept evaluation with 11 participants presented. The outcomes this research through project foreground importance challenges designing to support users. outline actionable...
Administered drugs are often converted into an ineffective or activated form by enzymes in our body. Conventional silico prediction approaches focused on therapeutically important such as CYP450. However, there more than thousands of different cellular that potentially convert administered drug other forms. We developed model to predict which human including metabolic well CYP450 family can catalyze a given chemical compound. The is based the and physical similarity between known enzyme...
We report on the ac and reverse recovery behavior of organic pentacene/ZnO thin-film diodes fabricated plastic substrate. The 50 nm thin pentacene was evaporated 60 ZnO that deposited by atomic layer deposition at . Our diode showed a much faster compared to Si control diode, although it also reveals lower forward current 2.5 V than (10 mA 0.6 V). It is because our has little influence minority carrier unlike diode. thus conclude promising as fast switching device.
Background: Transvenous lead extraction (TLE) may be indicated for cardiac implantable electronic device infection, malfunction, or upgrade. TLE can increase right heart pressures and mobilize debris, resulting in a right-to-left embolism stroke via patent foramen ovale (PFO). Aims: To identify the prevalence of PFO patients undergoing TLE, characterize affected patients, compare incidence adverse events. Hypothesis: The presence will result higher Methods: Intraoperative transesophageal...
Utilizing a quark model characterized by parameters that effectively replicate the masses of ground state hadrons, we illustrate (us) or (ds) diquarks exhibit greater compactness in comparison to (ud) diquarks. Concretely, binding energy diquark - defined as diquark's mass minus combined its individual quarks is found be stronger than diquark. This heightened attraction present could lead enhanced production Ξc/D particles high-energy pp ultrarelativistic heavy-ion collisions.
분광법을 이용한 많은 응용에서 스펙트럼 데이터의 기준선 보정은 분석 시스템의 성능을 좌우하는 매우 중요한 과정이다. 기준선은 경우에 육안 검사로 매개변수를 선택하여 추정한다. 이 과정은 주관적이고 특히 대량의 데이터인 경우 지루한 작업을 동반하므로 좋은 결과를 보장하기 어렵다. 이러한 이유로 보정에서 최적의 자동으로 선택하기 위한 객관적인 방법이 필요하다. 이전의 연구에서 PLS(penalized least squares) 방법에 새로운 가중 방식을 도입하여 기준선을 추정하는 arPLS(asymmetrically reweighted PLS) 방법을 제안하였다. 본 연구에서는 arPLS 방법에서 선택하는 제안한다. 방법은 가능한 매개변수의 범위에서 추정한 기준선의 적응도와 평활도를 계산한 다음 정규화한 평활도의 합이 최소가 되는 선택한다. 경사 기준선, 곡선 이중 모의실험 데이터와 실제 라만 스펙트럼을 실험에서 제안한 보정을 최적 선택에 효과적으로 적용될 수 있음을 확인하였다.
기저 세포암은 가장 일반적인 피부암이고 그 발병이 급속도로 증가하고 있다. 본 연구에서는 피부 조직에서 측정한 라만 스펙트럼에서 세포암 진단을 위해 NMF(non-negative matrix factorization) 알고리즘을 사용하는 방법을 제안하였다. 측정된 스펙트럼은 영역 선택과 정규화 등의 몇 가지 전처리 과정을 거쳐 분류 실험에 사용한다. 수행한 NMF 이용하여 분해된 행렬의 열벡터를 기저로 이 기저들을 선형 결합하여 각 클래스의 평균 스펙트럼에 근사하기 위한 가중치는 행렬 연산으로 결정한다. 실험은 스펙트럼과 NMF에 의한 기저와 가중치의 결합 스펙트럼의 차에 대한 제곱평균제곱근을 최소로 하는 클래스를 선택하는 것으로 수행한다. 세포암의 실험에서 제안한 경우가 약 99.1%의 분류율로 이전의 BCC 진단에 사용한 방법보다 2-3% 정도의 향상된 성능을 보였다.
Modifications to the New Zealand Building Code are currently being considered, which may create a requirement assess impact noise horizontally not just vertically. The test would be similar vertical tests as described in ISO 140-7:1998, but sound pressure levels proposed measured instead closest living space an adjacent apartment shares common floor system. This work seeks identify and validate different mathematical computational methods for predicting results of horizontal tests. Three...
In this study, we investigated skin cancer classification methods based on confocal Raman spectroscopy using maximum a posterior probability, fuzzy algorithm and support vector machine (SVM). The preprocessing steps were consisted of data normalization with minmax method dimension reduction principal components analysis. To enhance the performance, divided spectra into three significant protein bands, i.e., Amide I mode composed two normal BCC tissue III mode. All features extracted...
In spectroscopy, matching a measured spectrum to reference in large database is often computationally intensive. To solve this problem, we propose novel fast search algorithm that finds the most similar database. The proposed method based on principal component transformation and provides results equivalent traditional full method. reduce range, hierarchical clustering employed, which divides spectral data into multiple clusters according similarity of spectrum, allowing start at cluster...