We found that exposure of adult animals to calorie-dense foods rapidly abolished expression mitofusin 2 (Mfn2), a gene promoting mitochondrial fusion and mitochondrion-endoplasmic reticulum interactions, in white brown fat. Mfn2 mRN was also robustly lower obese human subjects compared with lean controls. Adipocyte-specific knockdown mice led increased food intake, adiposity, impaired glucose metabolism on standard chow as well diet high calorie content. The body weight adiposity mature...

Fractures in Elderly Americans Associated With Walking Leashed DogsDog walking is often suggested as an effective modality for improving physical health elderly Americans. 1 Nonetheless, injury risks associated with dog remain obscure.Considering that older patients are more vulnerable to fractures owing falls or axial muscle compression forces inherent motions, a risk-benefit analysis respect exercise alternative essential minimizing risk. 2 This study represents comprehensive, up-todate...

Introduction: Orthopaedic surgeons often cite concern for a learning curve as barrier to adopting the direct anterior approach (DAA) total hip arthroplasty (THA) while transitioning from other approaches. Studies both assessing and describing practical strategy safely accomplish this transition, well effect on clinical outcomes, are not described. Methods: This prospective study compares single surgeon's operative results complications first consecutive 100 THA last posterior after 7 years...

Introduction: Prosthetic hip dislocation is a common, costly complication of total arthroplasty (THA). Despite this, the national burden prosthetic dislocations remains uncharacterised in United States, especially pertaining to injuries occurring years after index procedure. This study examines historical and projected estimates presenting U.S. emergency departments between 2000 2035. Methods: We conducted cross-sectional, retrospective epidemiological using narratives National Electronic...

Background: Kickball is a popular childhood game most frequently played during gym class or recess at schools throughout the United States (US). Despite this, national health burden of injuries associated with kickball has never been explored in US pediatric population. Purpose: To report estimates and demographic characteristics patients presenting to emergency departments between 2000 2017 kickball-associated injuries. Study Design: Descriptive epidemiology study. Methods: This study...

Abstract Weightlifting is associated with a significant risk of shoulder injury. We used the National Electronic Injury Surveillance System (NEISS) database to identify patients presenting U.S. emergency departments between 2000 and 2017 weightlifting-associated injuries determine how health burden demographic characteristics these have changed over time. Our analyses demonstrated increase in national estimate (N=8.073; C.I. 6.309–9.836) (N=14.612; 12.293–16.930) (p<0.001), linear...

<h3>Importance</h3> Graduate medical education (GME) funding consists of more than $10 billion annual subsidies awarded to academic hospitals offset the cost resident training. Critics have questioned utility these and accountability recipient hospitals. <h3>Objective</h3> To determine association GME with hospital performance by examining 3 domains operations: financial standing, clinical outcomes, performance. <h3>Design, Setting, Participants</h3> This study is an economic evaluation all...

The epidemiology of acute vertebral fractures (AVFs) sustained while skiing and snowboarding remains poorly defined in the United States.It was hypothesized that there would be no significant differences across sex a greater number AVFs younger age groups associated with snowboarding.Descriptive epidemiological study.The authors utilized National Electronic Injury Surveillance System to identify patients who were reported emergency departments States from 2000 2019. All noted have during or...

BACKGROUND: Sports-related concussions (SRC) and closed head injuries (CHI) have recently garnered national attention given mounting concern for long-term neurological sequelae resulting from repetitive trauma. Despite historically dangerous techniques in wrestling that involve impacts to the head, there is a paucity of epidemiologic data regard wrestling-related (WRCs) United States (USA).METHODS: The National Electronic Injury Surveillance System (NEISS) database was queried (2000-2018)...

The national burden of radial head subluxations in the United States (U.S.) population is poorly defined, and non-classical injury mechanisms have been increasingly reported recent years. purpose this study to report historical estimates demographic characteristics patients presenting U.S. emergency departments (ED) with head.This cross-sectional, retrospective analyzes National Electronic Injury Surveillance System (NEISS) database (2001-2017) identify ≤ 7 years age EDs head.Linear...

Wrestling is a physically demanding sport with an inherently high risk of injury relative to other sports. Injury factors may change dramatically for athletes participating in off-season wrestling, given exposure new opponents, training methods, and wrestling styles compared in-season months; however, this has never been elucidated the literature. This study seeks characterize injuries sustained while compare them during months middle school age athletes.The National Electronic Surveillance...

Fireworks may result in a wide spectrum of injury to the upper extremity ranging from mild burns amputation. In this cross-sectional study, we describe epidemiology upper-extremity injuries United States associated with fireworks using Consumer Product Safety Commission's National Electronic Injury Surveillance System (NEISS).The NEISS database was queried between 2011 and 2017 for all (from shoulder fingertip) fireworks. There were 806 unique cases, yielding total weighted estimate 31,430...

Wrestling is one of the fastest-growing sports among females in United States (US). However, female wrestling injuries remain poorly characterized. In this study we describe historical and projected national estimates injuries, compare injury characteristics with those male wrestlers.We queried National Electronic Injury Surveillance System (NEISS) database (2005-2019) to weighted vs wrestlers presenting US emergency departments (ED) annual expected by 2030.Our analyses demonstrated a...

Insertion of a superior pubic ramus screw may be indicated for the treatment chronic pelvic discontinuity when utilizing acetabular distraction in revision total hip arthroplasty (THA), especially setting severe bone loss ischium. The aim this procedure is to stabilize and prevent abduction failure component distraction.With patient lateral decubitus position, acetabulum exposed from standard posterior approach THA. location root identified after making recess within anteroinferior capsule....

Athletics confer cardiovascular fitness and improved cognitive processing in pediatric populations. However, one risk of sports participation is acute vertebral fracture, an injury with significant morbidity. It currently unknown which represent the highest fracture This study seeks to identify youth sporting activities most commonly associated fractures presenting United States (U.S.) emergency departments (EDs).This cross-sectional, retrospective queries National Electronic Injury...

The epidemiology of sports-related concussions (SRCs) and closed head injuries (CHIs) in high school females remains undefined at the national level, especially for unorganized sports recreational activities. This study examines 1,176,092 weighted estimates SRCs or CHIs female patients 14–18 years age presenting to United States (US) emergency departments (EDs) between 2000 2019 National Electronic Injury Surveillance System (NEISS). estimate our increased significantly (p < 0.001) (9,835;...

The nature of wrestling may lead athletes to mask injuries with the delayed presentations youth wrestling-related not being well characterized.