A5078449236- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Invertebrate Immune Response Mechanisms
- Animal Behavior and Reproduction
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Retinal Development and Disorders
- Circadian rhythm and melatonin
Institute of Cellular and Organismic Biology, Academia Sinica
2018-2022
National Taiwan University
2016
Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs, with five subtypes named M1–M5) are a unique subclass of RGCs axons that project directly to many brain nuclei involved in non-image-forming functions such as circadian photoentrainment and the pupillary light reflex. Recent evidence suggests melanopsin-based signals also influence image-forming visual function, including adaptation, but mechanisms unclear. Intriguingly, small population M1 ipRGCs have...
Abstract Drosophila olfactory local interneurons (LNs) in the antennal lobe are highly diverse and variable. How when distinct types of LNs emerge, differentiate, integrate into circuit is unknown. Through systematic developmental analyses, we found that recruited to adult three groups. Group 1 residual larval LNs. 2 adult-specific emerge before cognate sensory projection neurons establish synaptic specificity, 3 after specificity established. selectively reintegrated through pruning...
Several large or mid-scale collections of Drosophila enhancer traps have been recently created to allow for genetic swapping GAL4 coding sequences versatile transcription activators suppressors such as LexA, QF, split-GAL4 (GAL4-AD and GAL4-DBD), GAL80 QS. Yet a systematic analysis the feasibility reproducibility these tools is lacking. Here we focused on InSITE drivers that specifically label different subpopulations olfactory neurons, particularly local interneurons (LNs), genetically...
Variations in neuronal connectivity occur widely nervous systems from invertebrates to mammals. Yet, it is unclear how variability originates, what extent and at time scales exists, functional consequences might carry. To assess inter- intraindividual variability, would be ideal analyze the same identified neuron across different brain hemispheres individuals. Here, using genetic labeling electron microscopy connectomics, we show that an inhibitory olfactory local interneuron, TC-LN,...