A5042776831- RNA and protein synthesis mechanisms
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- DNA and Nucleic Acid Chemistry
- Radioactive contamination and transfer
- Radioactivity and Radon Measurements
- Nuclear and radioactivity studies
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Hepatitis C virus research
- Radiation Effects and Dosimetry
- Chemical Synthesis and Analysis
- Advanced X-ray and CT Imaging
- RNA modifications and cancer
- Fungal Plant Pathogen Control
- Atomic and Molecular Physics
- Viral Infections and Immunology Research
- Bacterial Genetics and Biotechnology
- 3D Printing in Biomedical Research
- Graphite, nuclear technology, radiation studies
- Plant Surface Properties and Treatments
- Influenza Virus Research Studies
- X-ray Spectroscopy and Fluorescence Analysis
- Gastric Cancer Management and Outcomes
Scripps Research Institute
1999-2001
University of Vienna
1996
University of British Columbia
1994-1996
TRIUMF
1988
The University of Melbourne
1924-1946
Cavendish Hospital
1923
A cytidine-free ribozyme with RNA ligase activity was obtained by in vitro evolution, starting from a pool of random-sequence RNAs that contained only guanosine, adenosine, and uridine. This contains 74 nt catalyzes formation 3',5'-phosphodiester linkage catalytic rate 0.016 min(-1). The adopts simple secondary structure based on three-way junction motif, ligation occurring at the end stem region located several nucleotides away junction. Cytidine introduced to combinatorial fashion...
There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationships pursuing these has remained elusive. One the best-studied tertiary-structured theophylline aptamer, which binds with high affinity and selectivity. Although not drug target, this aptamer had many applications, especially pertaining to genetic...
For a considerable time after the discovery of radio-activity, it was thought that all α-rays emitted by given substance possessed definite velocity and hence range. It shown, however, Hahn, in 1906, active deposit thorium two distinct sets with ranges 4·8 8·6 cm. respectively. Although these were at first to arise from successive products, subsequently established they result different methods disintegration parent atom, C. Marsden Barratt able show when C breaks up, 65 per cent. atoms...
The photographic action of γ-rays from radium and radon in equilibrium with their short-lived products has been investigated, the rays being filtered lead screens thicknesses 0, 0.19, 1.42, 2.61 4.03 cm. variations density both time intensity have examined. shape characteristic (C) curves (D - log I) found to be independent filtering, same holds for Hurter-Driffield (H.D.) t), except when no filter is used. value p Schwarzschild relation, D = f (Itp), unity all filters. absorption...
With the discovery of new groups α-rays long range from radium C and thorium C, question emission small long-range particles all radioactive substances, which emits a group α-rays, naturally presented itself. Polonium, 3∙93 cm. in air at 15° C. pressure 760 mm. mercury, was once considered substance that might be investigated with advantage. The method investigation previously employed examination above sources. A source placed known distance zinc sulphide screen numbers scintillations were...
In continuation of earlier work in which the photographic action γ-rays was examined, absorption from radium (B + C) filtered by 1.6 cm. lead has been measured a method. With this filter is exponential. The μe per electron for lighter elements found to be constant, accordance with Klein-Nishina formula; and value, 1.56 × 10-25, corresponds wave-length 7.0 X.U. increase heavier excess vary as Z3, so that additional assumed due photoelectric effect. It that, assuming term λ2.2, an approximate...
Lysinomicin, a naturally-occurring pseudodisaccharide, inhibits translation in prokaryotes. We report that lysinomicin (and three related compounds) are able to inhibit the self-splicing of group I introns, thus identifying pseudodisaccharides as novel class intron splicing inhibitors. Lysinomicin inhibited sunY phage T4 with K 8.5 μM (+ / - 5μM) and was active against other introns. Inhibition found be competitive substrate guanosine, unlike aminoglycoside antibiotics, which act...
The photographic action of γ rays is intensified by using technical X-ray intensifying screens more than lead foil. These screens, however, intensify the longer wave-lenghts shorter. It has been found that heterochromatic γ-ray spectrum from radium (B+C) can be analysed into two apparently homogeneous components. Both components, appear to have an effective wave-length which shorter higher atomic number absorbing material. results explained, at least approximately, a consideration absorption...
The absorption of the γ rays from Ra (B+C) in barium sulphate plaster, water and beef, has been investigated by a photographic method. results obtained for this plaster are compared with those Kaye, Sievert Thoræus, X rays. thickness adequate protection against discussed. emergent intensities different thicknesses up to 20 cm. have measured.