A5087654635- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Heavy Metal Exposure and Toxicity
- Breast Implant and Reconstruction
- Legal and Labor Studies
- Trace Elements in Health
- European Criminal Justice and Data Protection
- HER2/EGFR in Cancer Research
- Safe Handling of Antineoplastic Drugs
- Nanoparticles: synthesis and applications
- Digital Rights Management and Security
- Privacy-Preserving Technologies in Data
- Mercury impact and mitigation studies
- IoT and Edge/Fog Computing
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Privacy, Security, and Data Protection
- Cardiac, Anesthesia and Surgical Outcomes
- Selenium in Biological Systems
- Blockchain Technology Applications and Security
- Management, Economics, and Public Policy
- Multiple and Secondary Primary Cancers
- Chronic Lymphocytic Leukemia Research
- Digital and Cyber Forensics
- Pharmaceutical studies and practices
Azienda Ospedaliera San Giovanni Addolorata
2009-2024
University of Cagliari
2019-2023
Institute of Biomedical Science
2021
Istituto Sperimentale Modelli E Strutture
2019
Consorzio Nazionale Interuniversitario per le Telecomunicazioni
2019
Joint Research Centre
2005-2011
European Commission
2009
University of Chieti-Pescara
2008
Ospedale San Luigi Gonzaga
1996-1998
Owing to the increasing development of nanotechnology, there is a need assess how engineered nanomaterials can interact with living cells. The main purpose present study was whether metal cobalt nanoparticles (CoNP 100–500 nm) are genotoxic compared ions (Co2+). Uptake experiments were carried out by incubating peripheral blood leukocytes (PBLs) 57Co2+ (added stable Co2+ 10−2 M obtain concentrations in range 10−5 10−4 M) or 60CoNP for 24 and 48 h. Whereas intracellular showed slight no...
We previously described the behaviour of different cobalt forms, i.e., nanoparticles (CoNP), microparticles (CoMP) and ions (Co(2+)), in culture medium (dissolution, interaction with components, bioavailability) as well their uptake intracellular distribution Balb/3T3 mouse fibroblasts (Sabbioni, Nanotoxicology, 2012). Here, we assess cytotoxicity morphological transformation CoNP compared not only to Co(2+), but also CoMP released Co products. Cytotoxicity reached maximum at 4-h exposure,...
The mechanistic understanding of nanotoxicity requires the physico-chemical characterisation nanoparticles (NP), and their comparative investigation relative to corresponding ions microparticles (MP). Following this approach, authors studied dissolution, interaction with medium components, bioavailability in culture medium, uptake intracellular distribution radiolabelled Co forms (CoNP, CoMP Co2+) Balb/3T3 mouse fibroblasts. Co2+ first saturates binding sites molecules extracellular milieu...
Nipple-sparing mastectomy (NSM) improves cosmetic results after mastectomy. As most consider advanced tumors, or tumors near the nipple-areola complex (NAC), as a contraindication for this type of surgery, we challenged hypothesis.One hundred thirty-eight NSM were performed in 121 consecutive patients. In 122 procedures cancer, patients included if there was no evidence NAC proximity (<1 cm), and retro-areolar margin negative, even locally neoadjuvant chemotherapy.Total necrosis occurred six...
Introduction: Subcutaneous versions of different oncology therapies have been available for patients a few years, yet patient-relevant and hospital benefits not assessed in real life. Methods: In order to analyze the impact subcutaneous administrations rituximab or trastuzumab comparison respective intravenous mode primary research Italy was executed. The study's objectives were resource cost implications from perspectives (patient, medical staff) world. route administration discussed...
Coast erosion is a process that degrades coastal profile and mainly due to natural factors (e.g., related climate change) overcrowding urbanization massive tourism).While the first cause can be considered as slow process, growing presence of humans leading rapid aging coasts.The Mediterranean Sea authorities are focusing on necessity for systematic comprehensive approach management littoral areas.In this context, Italy searching promising solution safeguard coasts but, at same time, manage...
Papillary thyroid microcarcinoma (PTMC) represents 35–40% of all papillary cancers; it is defined as a nodule ≤ 10 mm at the time histological diagnosis. The clinical significance PTMC still controversial, and may be discovered in two settings: incidental (iPTMC), which identified postoperatively upon examination specimens following surgery for benign disease, nonincidental (niPTMC), diagnosed before surgery. While iPTMC appears to related mild behavior favorable outcomes, niPTMC exhibit...
Inorganic arsenic is nongenotoxic in the Drosophila melanogaster wing somatic mutation and recombination test (SMART). Recent evidence mammalian systems indicates that methylated metabolites of are more genotoxic than inorganic arsenic. Thus, we hypothesized because they unable to biotransform forms. In present study, fed trivalent pentavalent larvae adults measured production derivatives. No biomethylated species were found organisms or growth medium, which suggests biomethylate Exposure...
Abstract The use of germanium (Ge) and the possibility exposure to trace ultratrace amounts this element is increasing. Germanium widely used in industrial field as a semiconductor also dietary supplement, an elixir ‘promote health cure disease’ (e.g. cancer AIDS). More recently, nanoparticles, ranging size from 60 80 nm, have been developed potential spleen imaging agent. Like other metal‐based nanoparticles nanomedicine, Ge may release ions when injected. metabolic fate toxicity these...
The rapid increase in Internet of Things (IoT) applications has raised security and privacy issues due to the huge amount data acquired by IoT devices transmitted through Internet. Therefore, there is a need understand what strategies should be applied make systems robust flaws weaknesses. In this paper, we first identify discuss best practices for security, which include set procedures that can taken as guidelines determine solve systems. Then, follow apply identified two real IoT-based use...
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite advancements in surgical techniques and perioperative care, patient outcomes vary significantly across healthcare institutions. Textbook outcome (TO), composite metric representing an ideal postoperative course, has been proposed as standard for assessing the quality care CRC. However, its impact on remains underexplored, particularly diverse clinical settings. Objective: This study aims to...
The recent European Commission REACH (Registration, Evaluation and Authorisation of Chemicals) policy outlines a plan for toxicological testing by using alternative non-animal in vitro methods. In this context, there is need to develop standardise high-throughput screening (HTS) methods studying the cytotoxicity induced chemicals. Electrochemical impedance spectroscopy (EIS) can be considered as complementary technique cell adhesion substrate, give real-time kinetic information on responses...