A5072025114- Innovative Microfluidic and Catalytic Techniques Innovation
- Crystallization and Solubility Studies
- Process Optimization and Integration
- Advanced Control Systems Optimization
- Analytical Chemistry and Chromatography
- Advanced Polymer Synthesis and Characterization
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Multi-Objective Optimization Algorithms
- Freezing and Crystallization Processes
- Carbon Dioxide Capture Technologies
- Membrane Separation and Gas Transport
- Probabilistic and Robust Engineering Design
- Viral Infectious Diseases and Gene Expression in Insects
- Electrowetting and Microfluidic Technologies
- Chemistry and Chemical Engineering
- Covalent Organic Framework Applications
- Drug Solubulity and Delivery Systems
- nanoparticles nucleation surface interactions
- Optimal Experimental Design Methods
- Membrane Separation Technologies
- Computational Drug Discovery Methods
- Wastewater Treatment and Nitrogen Removal
- Biosimilars and Bioanalytical Methods
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrohydrodynamics and Fluid Dynamics
Loughborough University
2015-2025
Engineering and Physical Sciences Research Council
2017-2018
Laboratoire de Tribologie et Dynamique des Systèmes
2015
Massachusetts Institute of Technology
2012-2014
Centre National de la Recherche Scientifique
2010-2012
Laboratoire Réactions et Génie des Procédés
2011-2012
Université de Lorraine
2009-2011
Laboratoire de Génie Chimique
2009-2010
Département de Chimie Moléculaire
2009
A series of tubes: The continuous manufacture a finished drug product starting from chemical intermediates is reported. pilot-scale plant used novel route that incorporated many advantages continuous-flow processes to produce active pharmaceutical ingredients and the in one integrated system. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or...
The synthesis of active pharmaceutical ingredients (APIs) is commonly perceived as more efficient when performed using continuous-flow methods, whereas batch processes are often seen less favorable due to their limitations in yield, heat and mass transfer, safety. This perception largely stems from existing studies that focus on green metrics such the E-factor yield. However, a comprehensive comparison flow through full techno-economic analyses (TEA) life-cycle assessments (LCA) remains...
The development and operation of the synthesis workup steps a fully integrated, continuous manufacturing plant for synthesizing aliskiren, small molecule pharmaceutical, are presented. started with advanced intermediates, two synthetic away from final active pharmaceutical ingredient, ended finished tablets. entire process was run on several occasions, data presented herein corresponding to 240 h at nominal throughput 41 g h–1 aliskiren. first reaction performed solvent-free in molten...
The pharmaceutical industry has historically benefited from high profit margins for their products, and over the years limited efforts have been made to change main manufacturing concept batch into continuous. However, past decade, as a result of an increased demand more efficient cost-effective processes, interest grown in application continuous address economical technical issues field. This option is becoming viable, particularly with implementation new process analytical technology...
The design of an effective plant‐wide control strategy is a key challenge for the development future continuous pharmaceutical processes. This article presents case study structure system inspired by end‐to‐end pilot plant. A hierarchical decomposition used to classify objectives. dynamic model process generate parametric sensitivities, which provide basis synthesis loops. Simulations selected disturbances illustrate that critical quality attributes (CQAs) final product can be kept close...
Eine Serie von Röhren: Ein kontinuierlicher Prozess für die Herstellung eines Medikaments aus chemischen Intermediaten wird beschrieben. Die Anlage im Pilotmaßstab nutzt viele Vorteile Flussverfahren, um aktiven pharmazeutischen Inhaltsstoffe und das Medikament in einem integrierten System herzustellen. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but...
Continuous manufacturing offers potential opportunities for the improved of pharmaceutical products. A key challenge is development an appropriate control strategy. The experimental application automated strategy presented end-to-end continuous pilot plant. process starts from advanced intermediate compound and finishes with tablet formation steps. focus results on design performance loops needed to produce a slurry active ingredient solvent specified material properties. demonstrate that...
A series of poly[methacrylamide-co-(ethylene glycol dimethacrylate)] (poly(MAAM-co-EGDMA)) porous polymeric particles with high CO2-philicity, referred to as HCP-MAAMs, were synthesised for CO2 capture. The polymers a MAAM-to-EGDMA molar ratio from 0.3 0.9 inherently nitrogen-enriched and exhibited affinity towards selective capture at low pressures. techno-economic model based on 580 MWel supercritical coal-fired power plant scenario was developed evaluate the performance adsorbents....
A reliable glass capillary microfluidic method was developed for a continuous production of well-controlled gold nanoparticles (AuNPs) capped with polyvinylpyrrolidone (PVP) different molecular weights (PVP K15, PVP K30 and K90). two-phase co-flow device an injection orifice diameter ranging between 100 240 µm used to synthesise 100–240 AuNPs via the chemical reduction tetrachloroaurate trihydrate (HAuCl4·3H2O) ascorbic acid. average 48 135 nm were synthesised, as determined by DLS...
Additive crystallization routes to control the crystal habit of active pharmaceutical ingredient (API) lovastatin are presented, at small scale up 25 mL. Lovastatin is an archetypical example API that forms needle-like crystals via solution-based recrystallization, causing issues for downstream processing stages. In this work, size and shape needles shown be subtly influenced by solvent, concentration, procedure, with moderately hygroscopic ethyl acetate solvent producing improved aspect...
In the pharmaceutical industries, requirements of rapid process development and scalable design have made tubular crystallizer a promising platform for continuous manufacturing crystallization processes, capable replacing conventional capital- labor-intensive batch operations. This paper takes systems engineering (PSE) approach to optimal antisolvent addition deliver most product qualities, such as crystal size distribution. A multisegment multiaddition plug-flow (MSMA-PFC) is considered an...
The development of reliable mathematical models for crystallization processes may be very challenging due the complexity underlying phenomena, inherent Population Balance Models (PBMs) and large number parameters that need to identified from experimental data. Due poor information content experiments, structure model itself correlation between parameters, contain more than can accurately reliably available A novel framework parameter estimability guaranteed optimal reliability is proposed...
Novel cost effective, versatile, reconfigurable, reusable and easy to assemble glass capillary microfluidic devices were developed used generate micro/nano-materials with controlled size morphology. The are composed of coaxial assemblies capillaries held between two interchangeable plastic blocks fabricated from chemically inert polyoxymethylene copolymer using computer numerical control (CNC) machining. Three different combined locked together Lego® inspired stud-and-hole coupling system...
Porous polymeric adsorbents for CO2 capture (HCP-MAAMs) were fabricated by copolymerization of methacrylamide (MAAM) and ethylene glycol dimethacrylate using acetonitrile azobisisobutyronitrile as a porogen initiator, respectively. The X-ray photoelectron Fourier transform infrared spectra revealed high density amide groups in the polymer matrix HCP-MAAMs, which enabled selectivity to CO2. BET surface area total pore volume was up 277 m2 g–1 0.91 cm3 g–1, highest uptake at 273 K 1 bar...
A solution layer crystallization process in a concentric annulus is presented that removes the need for filtration. dynamic model with and without recirculation loop developed form of coupled partial differential equations describing effects mass transfer, heat kinetics. The predicts variation temperature, concentration, crystal thickness along pipe length, concentration temperature radius. predictions are shown to closely track experimental data were not used model's construction, also...
The judicious use of buffering capacity is important in the development future continuous pharmaceutical manufacturing processes. potential benefits are investigated using optimal-averaging level control for tanks that have a section pilot plant involving two crystallizers, combined filtration and washing stage buffer tank. A closed-loop dynamic model utilized to represent experimental operation, with relevant parameters initial conditions estimated from data contained significant...