A5019245550- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Melanoma and MAPK Pathways
- Mechanisms of cancer metastasis
- RNA Research and Splicing
- Allergic Rhinitis and Sensitization
- Circular RNAs in diseases
- Neonatal Respiratory Health Research
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- Complementary and Alternative Medicine Studies
- Ion Channels and Receptors
- Telomeres, Telomerase, and Senescence
- RNA modifications and cancer
- Kruppel-like factors research
- Nitric Oxide and Endothelin Effects
University of South Alabama
2011-2020
Eli Lilly (United States)
2018-2020
Indiana University – Purdue University Indianapolis
2015-2016
MicroRNA (miR)-146a and miR-146b are negative regulators of inflammatory gene expression in lung fibroblasts, epithelial cells, monocytes, endothelial cells. The abundance cyclooxygenase-2 (COX-2) IL-1β is negatively regulated by the miR-146 family, suggesting miR-146a and/or might modulate mediator airway smooth muscle thereby contributing to pathogenesis asthma. To test this idea we compared human cells (hASMCs) from nonasthmatic asthmatic subjects treated with cytomix (IL-1β, TNF-α, IFNγ)...
Cyclooxygenase-2 (COX-2) expression and PGE2 secretion from human airway smooth muscle cells (hASMCs) may contribute to β2-adrenoceptor hyporesponsiveness, a clinical feature observed in some patients with asthma. hASMCs asthma exhibit elevated of cytokine-responsive genes, instances this is attributable an altered histone code and/or microRNA expression. We hypothesized that COX-2 might be asthmatic response proinflammatory signals part due acetylation obtained nonasthmatic subjects were...
During normal lung development and in diseases structural cells the lungs adapt to permit changes function. Fibroblasts, myofibroblasts, smooth muscle, epithelial cells, various progenitor can all undergo phenotypic modulation. In pulmonary vasculature occlusive vascular lesions that occur severe arterial hypertension are multifocal, polyclonal containing presumed have undergone transition resulting altered proliferation, cell lifespan or contractility. Dynamic gene expression protein...
Little is known regarding real-world health outcomes data among US psoriasis patients, but electronic records (EHR) that collect structured at point-of-care may provide opportunities to investigate patients. Our objective was patient-perceived treatment effectiveness, patterns of medication use (duration, switching, and/or discontinuation), healthcare resource utilization, and costs using from Data for adults (≥18-years) with a dermatology provider-given diagnosis 9/2014–9/2015 were obtained...
Activation of vascular endothelial small- (KCa2.3, SK3) or intermediate- (KCa3.1, IK1) conductance Ca(2+)-activated potassium channels induces vasorelaxation via an endothelium-derived hyperpolarization (EDH) pathway. Although the activation SK3 and IK1 converges on EDH, their subcellular effects signal transduction are different not completely clear. In this study, a novel endothelium-specific knockout (SK3(-/-)) mouse model was utilized to specifically examine contribution mesenteric...