Male, 48 FINAL DIAGNOSIS: Low dose cyclophosphamide-induced acute hepatotoxicity Symptoms: Epigastric pain Medication: Withdrawal of cyclophosphamide Clinical Procedure: - Specialty: Nephrology • Hepatology Gastroenterology Toxicology.Unexpected drug reaction.Cyclophosphamide is commonly used to treat cancers, systemic vasculitides, and kidney diseases (e.g., lupus nephritis focal segmental glomerulosclerosis). Acute adverse effects include bone marrow suppression, hemorrhagic cystitis,...

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease and despite the improvement in survival past few decades, morbidity due to damage remains significant. The objectives of this study were investigate damagepattern determine associated factors multi-ethnic Malaysian SLE patients. We consecutively 424SLE patients who attended consistent follow-up at National University Malaysia Medical Centre Putrajaya Hospital recruited. Disease was assessed using SLICC/ACR (Systemic...

Introduction: Hyperuricemia is associated with chronic kidney disease (CKD) progression and poor cardiovascular outcomes. We studied the effect of febuxostat on estimated glomerular filtration rate (eGFR), proteinuria monitored safety profile medication. Material Methods: This a prospective open-label, randomized study in CKD stage 3 4 patients diabetic nephropathy asymptomatic hyperuricemia. Patients were into 40 mg daily no treatment group using block randomization method followed up for 6...

Aims and objectives. The main objective of the study was to correlate target dry weight in haemodialysis (HD) patients as assessed clinically by nephrologists those measured Body Composition Monitor (BCM – Fresenius) machine. second compare pre postdialysis changes extracellular fluid clinical parameters. Background. Clinical assessment HD remains problematic. Inaccurate resulted hypovolaemic or overhydration states. BCM (Fresenius) utilises bioimpedance technology for body monitoring has...

Abstract Introduction The alteration of the gut microbiome in gut-kidney axis has been associated with a pro-inflammatory state and chronic kidney disease (CKD). A small-scaled Italian study shown an association between Immunoglobulin Nephropathy (IgAN). However, there is no data on microbiota IgAN Asian population. This compares microbial abundance diversity healthy volunteers Malaysian cohort. Methods comparative cross-sectional was conducted involving biopsy-proven patients clinical...

Avascular necrosis of bone (AVN) is increasingly being recognized as a complication SLE and causes significant disability due to pain mobility limitations. We studied the prevalence factors associated with avascular in multiethnic cohort. patients who visited outpatient clinic from October 2017 April 2019 were considered eligible. Their medical records reviewed identify developed symptomatic AVN, confirmed by either magnetic resonance imaging or plain radiography. Subsequently, their disease...

Secondary hyperparathyroidism (SHPT) is common among haemodialysis patients. Intensive treatment with calcitriol often complicated by hypercalcaemia, hyperphosphataemia and elevated calcium phosphorus (Ca X PO(4)) product. Paricalcitol a vitamin D analogue developed to overcome some of the limitations therapy. The study objectives were compare response intact parathyroid hormone (iPTH) incidence Ca PO(4) product in patients severe SHPT treated either i.v. or paricalcitol.This was single...

Flare of Systemic Lupus Erythematosus (SLE) may occur during pregnancy and puerperium. We studied the prevalence factors associated with SLE relapse post-partum period in a multi-ethnic cohort. Consecutive patients who attended outpatient clinic were reviewed for previous history pregnancies our institution. Patients had complete antenatal, delivery, follow up included. Their medical records retrospectively analysed to assess disease activity at pre-pregnancy/conception, period. Presence...

Coupled plasma filtration adsorption (CPFA) is a novel extracorporeal blood purification therapy for sepsis which adsorbs both proinflammatory and anti-inflammatory mediators from filtered plasma, thereby achieving early haemodynamic stability reduction in inotropic support requirement.The main objective was to review our centers' experience with CPFA septic patients.A retrospective chart of all patients who received performed. All were initially treated according the 'surviving care bundle'...

Introduction Cognitive impairment is a common neuropsychiatric manifestation of systemic lupus erythematosus (SLE). However, it not routinely assessed for despite its high prevalence and significant disease burden. Aims This study aimed to determine the mild cognitive (MCI) using Montreal Assessment (MoCA) associated factors among patients diagnosed with SLE in Malaysia. Methods A total 200 were recruited prospectively from outpatient clinics two tertiary hospitals Standardized clinical...

This study aims to assess the self-reported work productivity and activity daily living (ADL) impairment among Malaysian patients with systemic lupus erythematosus (SLE) examine their associated factors.This cross-sectional included 167 SLE (21 males, 146 females; mean age 38.2±9.8 years; range, 20 60 years) recruited from outpatient Rheumatology Nephrology clinics. Face-to-face interviews were conducted record patients' socio- demographics (age, sex, ethnicity, marital status, occupation)...

Introduction IgA nephropathy (IgAN) has a heterogeneous presentation and the progression to end stage renal disease (ESRD) is often influenced by demographics, ethnicity, as well choice of treatment regimen. In this study, we investigated long term survival IgAN patients in our center factors affecting it. Methods This study included all biopsy-proven with ≥ 1year follow-up. Patients diabetes mellitus at diagnosis secondary were excluded. Medical records reviewed for clinical presentation,...

Hypovitaminosis D (serum 25-OHD < 30 ng/mL) is common in patients with chronic kidney disease (CKD). Vitamin believed to involve the regulation of renin-angiotensin system and may be renoprotective.To compare effects calcium or without calcitriol on renal function CKD.A prospective randomized trial was performed involving stages 2-4 CKD hypovitaminosis D. Baseline demographics data were taken at baseline. Patients equally into oral plus carbonate (calcitriol group) alone (non-calcitriol...

Background Systemic lupus erythematosus (SLE) patients are a high-risk population for suicide. Glutamatergic neurosystem genes have been implicated in the neurobiology of depression SLE and suicidal behaviour general. However, role glutamate receptor gene polymorphisms among remains unclear context established clinical psychosocial factors. We aimed to investigate association NR2A polymorphism with ideation while accounting interaction between Methods A total 130 were assessed mood disorders...

To determine the prevalence of work disability (WD) among patients with systemic lupus erythematosus (SLE) and its associated factors.This was a cross-sectional study involving SLE aged 18-56 years from Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Employment history obtained clinical interviews. WD defined as unemployment, interruption employment or premature cessation due to at any time after diagnosis. disease characteristics, presence organ damage Safety Estrogens in Lupus...