A5042843493- Zebrafish Biomedical Research Applications
- Immune cells in cancer
- Cellular Mechanics and Interactions
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Pregnancy and preeclampsia studies
- Aquaculture disease management and microbiota
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
Centre National de la Recherche Scientifique
2017-2022
Institut Pasteur
2017-2022
Biologie du Développement et Cellules Souches
2022
University of Münster
2021
Sorbonne Université
2018
Hematopoiesis leads to the formation of blood and immune cells. Hematopoietic stem cells emerge during development, from vascular components, via a process called endothelial-to-hematopoietic transition (EHT). Here, we reveal essential biomechanical features EHT, using zebrafish embryo imaged at unprecedented spatio-temporal resolution an algorithm unwrap aorta into 2D-cartography. We show that involves anisotropic contraction along antero-posterior axis, with heterogenous organization...
ABSTRACT Macrophages infiltrate and establish in developing organs from an early stage, often before these have become vascularized. Similarly, leukocytes, general, can quickly migrate through tissues to any site of wounding. This unique capacity is rooted their characteristic amoeboid motility, the genetic basis which poorly understood. Trim33 (also known as Tif1-γ), a nuclear protein that associates with specific DNA-binding transcription factors modulate gene expression, has been found be...
Trim33 (Tif1γ) is a transcriptional regulator that notably involved in several aspects of hematopoiesis. It essential for the production erythrocytes zebrafish, and proper functioning aging hematopoietic stem progenitor cells (HSPCs) mice. Here, we have found that, zebrafish development, cell-autonomously lifespan yolk sac-derived primitive macrophages, as well initial definitive (HSPC-derived) macrophages first niche hematopoiesis, caudal tissue. Moreover, deficiency leads to an excess...
ABSTRACT TRIM33 (Tif1-γ) is a transcriptional regulator notably involved in several aspects of hematopoiesis. It essential for the production erythrocytes zebrafish, and proper functionning aging hematopoietic stem progenitor cells (HSPCs) mice. Here we have found that zebrafish development, Trim33 cell-autonomously lifespan yolk sac derived primitive macrophages, as well initial definitive (HSPC-derived) macrophages first niche hematopoiesis, caudal tissue. Moreover, deficiency leads to an...