Abnormal inflammatory mediator concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma in patients with Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized confirmed COVID-19 sorted into severity groups: severe (n=68) and mild or moderate (n=58), 134 healthy controls were enrolled. quantified 39 mediators using multiplex ELISA. Spearman rank correlation Mann-Whitney U test used identify mechanistically coupled compare Compared...

Neural tube defects (NTDs) are prevalent congenital associated with pre-pregnancy diet low levels of maternal folate. They linked to severe morbidity, disability, and mortality, as well psychological economic burdens.The goal this study was determine the folate, vitamin B12, homocysteine in blood women who had a pregnancy impacted by NTDs.A hospital-based case-control undertaken between September 2019 August 2020. The comprised total 100 cases 167 controls. Enzyme-linked immunosorbent assay...

Introduction Patients with Diabetes are at increased risk of severe COVID-19 and death, thus, it is imperative to provide them vaccination. Ad26.COV2. S vaccine has proven its efficacy. However, the immunological response patients diabetes in Ethiopia not been well studied. Methods This prospective cohort study assessed immune responses after vaccination a single dose Ad26.COV2.S. The subjects were enrolled diabetic who 18 years old above attended clinic Adama Hospital Medical College. A...

Diabetes type 2 is associated with impaired insulin production and increased resistance. Treatment antidiabetic drugs strives for normalizing glucose homeostasis. In Ethiopian traditional medicine, plant extracts of Melia azedarach are used to control diabetes mellitus various gastrointestinal disorders. The objective this study was clarify the effects M. leaf in diabetic experimental animals. study, mice were injected extract intraperitoneally. Plasma studied by using tail vein sampling...

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by severe joint pain, swelling, damage, and disability which leads to destruction loss of function. The complication RA associated with cardiovascular diseases, particularly due systemic inflammation dyslipidemia. purpose this study was assess the development atherosclerosis, acts as major risk factor for complications in patients.A hospital-based cross-sectional conducted at Rheumatology Clinic Tikur Anbessa...

Introduction In hospitalized COVID-19, neutrophil-to-lymphocyte ratio (NLR) and serum creatinine is sometimes measured under assumption they predict disease severity mortality. We determined the potential value of NLR as predictors mortality in COVID-19. Methods Prospective cohort study COVID-19 patients admitted to premier treatment hospitals Ethiopia. Predictive capability biomarkers progression prognosis was analyzed using receiver operating characteristics. Survival with different...

Malnutrition is a major underlying condition for mortality in children under five years of age developing countries, particularly Ethiopia. The most important forms malnutrition Ethiopia are protein and energy deficiencies. There no reliable laboratory method at present to assess acute malnutrition. Transthyretin homotetrameric serum with half-life two days. main objective this study was the estimation transthyretin level as useful diagnostic evaluate nutritional status children. We used...

The proportion of patients with end-stage renal disease caused by diabetes has progressively increased during the last few decades. Serum creatinine level is most commonly used biochemical parameter to estimate GFR in routine practice. However, 50% can be lost before significant elevation serum creatinine. Cystatin C found a new promising marker for early detection diseases.The aim this study was determine value cystatin and levels type 2 mellitus.A hospital-based comparative cross-sectional...

Abstract Background Aflatoxin is a toxic cancerous fungal secondary metabolite produced by Aspergillus species . Consumption of aflatoxin-contaminated cereals and their products can cause several health-related effects including acute chronic aflatoxicosis. This study aims to evaluate the total aflatoxin content in “Cheka” its major ingredients using Immuno-Affinity Column Clean-up technique sensitive HPLC (High-Performance Liquid Chromatography) with fluorescence detection. Methods followed...

This study aimed to determine the neutrophil-lymphocyte ratio (NLR) as an inflammatory biomarker among type 2 diabetes mellitus (T2DM) patients with diabetic nephropathy (DN).A comparative cross-sectional design was conducted on 199 T2DM attending Bole 17 Health Center, Addis Ababa, Ethiopia. The urine albumin test done by MICRAL-II strip. Fasting blood sugar measured a glucometer. Complete count analyzed using automated hematology analyzer (HUMAN GmbH, Wiesbaden, Hesse, Germany). student's...

Tumor lysis syndrome (TLS) is a life-threatening emergency disorder, caused by an abrupt release of intracellular metabolites after tumor cell death. It characterized series metabolic manifestations, especially hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. The aim this study was to evaluate characterize the incidence among pediatric oncology patients before treatment. Hospital based prospective cohort conducted for 6 months on 61 newly diagnosed patients. Socio-demographic...

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder, which associated with increased pro-inflammatory mediators to induce an elevation in acute-phase response, migration of immune cells and swelling synovial joints. Evaluation the level C-reactive protein risk factors RA patients was main aim this study. Identifying association between disease activity (hsCRP) socio-demographic characteristics another study.Institution-based cross-sectional study conducted at Rheumatology...

Background: Diabetic kidney disease (DKD) is one of the major complications Type 2 diabetes, clinically characterized by a progressive increase in albuminuria and/or subsequent decline glomerular filtration rate. Identification novel risk factors contributes to reduction diabetic disease. Bilirubin, as an antioxidant and anti-inflammatory molecule, believed have protective role On other hand, uric acid implicated pathogenesis DKD due its pro-oxidant pro-inflammatory property vascular...

Malaria is a leading cause of morbidity and mortality. Of the five Plasmodium species that malaria, P. falciparum deadliest. Oxidative stress might be increased in malaria patients contribute to severity complications. This may originate from intracellular parasitized erythrocytes extra-erythrocytes as result hemolysis host immune response. stress-induced oxidation hemoglobin methemoglobin further complications patients. The aim this study was estimate total oxidative non-enzymatic...

Cervical cancer is the seventh overall, but second most common in women worldwide. It of all ages Ethiopia. Radiotherapy one treatment strategies, its effect on production oxygen free radicals that leads to oxidative stress requires proper attention and investigation. In this study 43 patients with cervical carcinoma before course radiotherapy was assessed versus 20 normal subjects. Sera were collected at 4 time points from patients, i.e., radiotherapy, after 2, 4, 8 weeks only once...

ABSTRACT Abnormal cytokine and chemokine concentrations during SARS-CoV-2 infection may represent disease severity. We aimed to assess plasma in patients with Addis Ababa, Ethiopia. In this study, 260 adults: 126 hospitalized confirmed COVID-19 sorted into severity groups: severe (n=68) mild or moderate (n=58), 134 healthy controls were enrolled. quantified 39 cytokines chemokines using multiplex ELISA. Spearman rank correlation Mann-Whitney U test used identify mechanistically coupled...

Abstract Background : Type II diabetes is a major health problem worldwide, and increasing in an alarming rate globally Ethiopia due to change dietary habits sedentary life style. Even though there no effective cure for diabetes, early control of blood glucose significantly reduces the risk diabetic complications. Different types ingredients present medicinal plants that act on variety targets by various modes mechanisms are used treat with minimum cost side effect. Therefore, objective...

Edible oil is a vital component of our diet. It composed different types fatty acids. The type and proportion acid in determines the nutritional value, physical chemical properties edible also implicated its quality for consumption. main objective this study was to assess evaluate content their imported oils widely consumed Ethiopia. Five were analyzed composition by Gas chromatography coupled with mass spectrometric detector (GC-MS). Fatty profile determined after acids transformed...