A5017329624- RNA and protein synthesis mechanisms
- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- Nanoparticles: synthesis and applications
- RNA Research and Splicing
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- Plant-Microbe Interactions and Immunity
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Gas Sensing Nanomaterials and Sensors
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Curcumin's Biomedical Applications
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Legume Nitrogen Fixing Symbiosis
- CRISPR and Genetic Engineering
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Antioxidant Activity and Oxidative Stress
Maharishi Markandeshwar University, Mullana
2020-2025
Eternal University
2024
Institute of Medical Sciences
2021-2023
Shoolini University
2012-2022
ORCID
2021
Himachal Pradesh University
2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2008-2015
National Institutes of Health
2007-2014
Institute of Genomics and Integrative Biology
2004-2006
Ambedkar University Delhi
2004
In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation Met-tRNAi in a 'PIN' state, which is antagonized by factor eIF1. eIF5 GTPase activating protein (GAP) eIF2 that additionally promotes stringent selection, but molecular basis its dual function was unknown. We present cryo-electron microscopy (cryo-EM) reconstruction yeast 48S pre-initiation complex (PIC), at an overall resolution 3.0 Å, featuring N-terminal domain (NTD) bound to 40S subunit location...