A5049206696- SARS-CoV-2 and COVID-19 Research
- Signaling Pathways in Disease
- interferon and immune responses
- RNA Interference and Gene Delivery
- COVID-19 Clinical Research Studies
- Phagocytosis and Immune Regulation
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- RNA regulation and disease
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Plant Stress Responses and Tolerance
- Clostridium difficile and Clostridium perfringens research
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- PARP inhibition in cancer therapy
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
Ludwig-Maximilians-Universität München
2012-2024
German Center for Infection Research
2016-2024
Fudan University
2023
Shanghai Institute of Pharmaceutical Industry
2023
University of Lübeck
2016
Significance Severe acute respiratory syndrome coronavirus (SARS-CoV) is one of the most pathogenic human coronaviruses. Virulence reflected in molecular interplay between virus and host cells. Here we show a strategy how SARS-CoV antagonizes antiviral factor p53, which impairs viral replication. The papain-like protease nonstructural protein 3 other coronaviruses physically interact with stabilize E3 ubiquitin ligase ring-finger CHY zinc-finger domain-containing 1 (RCHY1), thereby...
Article20 April 2021Open Access Transparent process The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation Jian Lei Institute Biochemistry, Center for Structural Cell Biology in Medicine, University Lübeck, Germany German Infection Research (DZIF), Hamburg–Lübeck– Borstel–Riems Site, State Key Laboratory Biotherapy Cancer Center, National Clinical Geriatrics, West China Hospital, Sichuan University, Chengdu, Search more papers by...
Oxysterol-binding protein (OSBP) is known for its crucial role in lipid transport, facilitating cholesterol exchange between the Golgi apparatus and endoplasmic reticulum membranes. Despite established function cellular processes, involvement coronavirus replication remains unclear.
Rationale Human coronaviruses (HCoVs) seriously affect human health by causing respiratory diseases ranging from common colds to severe acute diseases. Immunophilins, including peptidyl-prolyl isomerases of the FK506-binding protein (FKBP) and cyclophilin family, are promising targets for pharmaceutical inhibition coronavirus replication, but cell-type specific effects have not been elucidated. FKBPs cyclophilins bind immunosuppressive drugs FK506 cyclosporine A (CsA), respectively. Methods...
Identification and development of effective therapeutics for coronavirus disease 2019 (COVID-19) are still urgently needed. The CD147-spike interaction is involved in the severe acute respiratory syndrome (SARS-CoV)-2 invasion process addition to angiotensin-converting enzyme 2 (ACE2). Cyclophilin A (CyPA), extracellular ligand CD147, has been found play a role infection replication coronaviruses. In this study, our results show that CyPA inhibitors such as cyclosporine (CsA) STG-175 can...