A5005689446- Chromosomal and Genetic Variations
- Insect Resistance and Genetics
- CRISPR and Genetic Engineering
- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Advanced biosensing and bioanalysis techniques
- Insect and Arachnid Ecology and Behavior
- Evolution and Genetic Dynamics
- RNA Research and Splicing
- Trace Elements in Health
- Entomopathogenic Microorganisms in Pest Control
- Genomics and Chromatin Dynamics
- Cell Image Analysis Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- RNA modifications and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Virus Research Studies
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Oil Palm Production and Sustainability
Institut de Biologia Evolutiva
2014-2021
Universitat Pompeu Fabra
2014-2021
Université Claude Bernard Lyon 1
2016
Centre National de la Recherche Scientifique
2016
Genetic variation is the fuel of evolution, with standing genetic especially important for short-term evolution and local adaptation. To date, studies spatiotemporal patterns in natural populations have been challenging, as comprehensive sampling logistically difficult, sequencing entire costly. Here, we address these issues using a collaborative approach, 48 pooled population samples from 32 locations, perform first continent-wide genomic analysis European Drosophila melanogaster. Our...
Abstract Drosophila melanogaster is a leading model in population genetics and genomics, growing number of whole-genome data sets from natural populations this species have been published over the last years. A major challenge integration disparate sets, often generated using different sequencing technologies bioinformatic pipelines, which hampers our ability to address questions about evolution species. Here we these issues by developing bioinformatics pipeline that maps pooled (Pool-Seq)...
Elucidating the fitness effects of natural genetic variants is one current major challenges in evolutionary biology. Understanding interplay between genotype, phenotype and environment necessary to make accurate predictions important biological outcomes such as stress resistance or yield economically plants animals, disease humans. Based on population frequency patterns footprints selection at DNA level, transposable element Bari-Jheh, inserted intergenic region Juvenile Hormone Epoxy...
Transposable elements are emerging as an important source of cis-acting regulatory sequences and epigenetic marks that could influence gene expression. However, few studies have dissected the role specific transposable element insertions on regulation. Bari-Jheh is a natural transposon mediates resistance to oxidative stress by adding cis-regulatory affect expression nearby genes. In this work, we integrated publicly available ChIP-seq piRNA data with chromatin immunoprecipitation...
Most of the genotype–phenotype analyses to date have largely centred attention on single nucleotide polymorphisms. However, transposable element (TE) insertions arisen as a plausible addition study genotypic–phenotypic link because their role in genome function and evolution. In this work, we investigate contribution TE regulation gene expression response insecticides. We exposed four Drosophila melanogaster strains malathion, commonly used organophosphate insecticide. By combining...
Abstract Genetic variation is the fuel of evolution, with standing genetic especially important for short-term evolution and local adaptation. To date, studies spatio-temporal patterns in natural populations have been challenging, as comprehensive sampling logistically difficult, sequencing entire costly. Here, we address these issues using a collaborative approach, 48 pooled population samples from 32 locations, perform first continent-wide genomic analysis European Drosophila melanogaster...
Abstract Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which conserved from Drosophila humans. MTF-1 binds metal elements (MREs) and changes expression target genes. kuzbanian (kuz ), a metalloendopeptidase that activates evolutionary Notch signaling pathway, has been identified an gene. We have previously putatively adaptive transposable...
Abstract Drosophila melanogaster is a leading model in population genetics and genomics, growing number of whole-genome datasets from natural populations this species have been published over the last 20 years. A major challenge integration these disparate datasets, often generated using different sequencing technologies bioinformatic pipelines, which hampers our ability to address questions about evolution structure species. Here we issues by developing bioinformatics pipeline that maps...
ABSTRACT Organisms must cope with altered environmental conditions such as high concentrations of heavy metals. Stress response to metals is mediated by the metal-responsive transcription factor 1 (MTF-1), which conserved from Drosophila humans. MTF-1 binds metal elements (MREs) and changes expression target genes. kuzbanian (kuz) , a metalloendopeptidase that activates evolutionary Notch signaling pathway, has been identified an gene. We have previously putatively adaptive transposable...
ABSTRACT Transposable elements are emerging as an important source of cis-acting regulatory sequences and epigenetic marks that could influence gene expression. However, few studies have dissected the role specific transposable element insertions on regulation. Bari-Jheh is a natural transposon mediates resistance to oxidative stress by adding cis-regulatory affect expression nearby genes. In this work, we integrated publicly available data with chromatin immunoprecipitation experiments get...