A5081769193- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Machine Learning in Bioinformatics
- Advanced Proteomics Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
Max Delbrück Center
2023
Alzheimer's disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb proteome in brains patients AD transgenic mouse models, remains largely unclear. State-of-the-art mass spectrometry (MS) methods can comprehensively detect proteomic alterations, providing relevant insights unobtainable with transcriptomics investigations. Analyses relationship between progressive aggregation protein abundance changes 5xFAD mice have...
Abstract Background Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptides in intra- and extracellular deposits. How Aβ aggregates perturb proteome brains patients AD transgenic mouse models, however, remains largely unclear. State-of-the-art mass spectrometry (MS) methods can comprehensively detect proteomic alterations neurodegenerative disorders, providing relevant insights unobtainable with transcriptomics investigations. Analyses relationship between...