A5072834388- Endoplasmic Reticulum Stress and Disease
- DNA Repair Mechanisms
- interferon and immune responses
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
AstraZeneca (United Kingdom)
2024
The Francis Crick Institute
2019
Abstract Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation selective removal of protein aggregates organelles by recruiting autophagy receptors adaptors that contain a LC3-interacting region (LIR) motif. LIR motifs can be highly for subfamily (LC3s/GABARAPs), however the molecular determinants regulating these interactions remain elusive. Here we show residues within core motif adjacent C-terminal as well subfamily-specific...
Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit melanoma lung cancer patients who progressed on immunotherapy. Here we show that modelling of intermittent treatment mouse tumor models reveals CD8 + T-cell dependent antitumor activity, which is separate from effects cells. Ceralasertib suppresses proliferating T-cells rapidly reversed off-treatment. causes up-regulation...