A5001759467- Coral and Marine Ecosystems Studies
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Genetic Associations and Epidemiology
- Marine Sponges and Natural Products
- Enzyme Production and Characterization
- Aquaculture disease management and microbiota
- Marine and coastal plant biology
- Biochemical Analysis and Sensing Techniques
- Fermentation and Sensory Analysis
- HIV/AIDS drug development and treatment
- Alzheimer's disease research and treatments
- Vitamin D Research Studies
- Ion channel regulation and function
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Immune Response and Inflammation
- Biochemical and biochemical processes
- Tryptophan and brain disorders
- HIV/AIDS Research and Interventions
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Genetics, Aging, and Longevity in Model Organisms
- Receptor Mechanisms and Signaling
Guangxi University
2021-2024
Public Health Clinical Center of Chengdu
2023
University of Miami
2012-2015
Genetic Improvement and Adaptation of Mediterranean and Tropical Plants
2015
Agropolis International
2015
Broad Institute
2015
Harvard University
2010
Pohang University of Science and Technology
2010
University of North Carolina at Chapel Hill
2003
Air Force Medical University
1995-2001
ABSTRACT The influence of gut microbes on aging has been reported in several studies, but the mediating pathways microbiota, whether there is a causal relationship between two, and biomarker screening validation have not fully discussed. In this study, Mendelian Randomization (MR) Linkage Disequilibrium Score Regression (LDSC) are used to systematically investigate associations three indicators, 14 age‐related diseases. Additionally, study integrates machine learning algorithms explore...
Abstract Regulation of cytoskeletal structure and dynamics is essential for multiple aspects cellular behavior, yet there much to learn about the molecular machinery underlying coordination between cytoskeleton its effector systems. One group proteins that regulate microtubule behavior interaction with other components, such as actin-regulatory transport machinery, plus-end tracking (MT+TIPs). In particular, evidence suggests MT+TIP, CLASP, may play a pivotal role in microtubules structures...
β-Glucosidase is a microbial cellulose multienzyme that plays an important role in the regulation of entire hydrolysis process, which rate-limiting step bacterial carbon cycling marine environments. Despite its importance coral reefs, diversity β-glucosidase-producing bacteria, their genes, and enzymatic characteristics are poorly understood. In this study, 87 cultivable bacteria were screened from 6 genera corals. The isolates assigned to 21 genera, distributed among three groups:...
Abstract Presynaptic N‐methyl‐D‐aspartate (NMDA) receptors in terminals of primary afferents to spinal cord rats were first reported by Liu et al. (1994; Proc. Natl. Acad. Sci. USA 91:8383–8387) and proposed modulate nociceptive input (Liu [1997] Nature 386:721–724). We previously demonstrated kainate AMPA numerous afferent the fixed with diluted paraformaldehyde no glutaraldehyde. Therefore, we reinvestigated occurrence presynaptic NMDAR1 (NR1) this fixation protocol. With confocal...
Treatment options for hospitalized people living with HIV/AIDS (PLWHA) opportunistic infections and comorbidities are limited in China. Albuvirtide (ABT), a new peptide drug, is long-acting HIV fusion inhibitor drug-drug interactions fast onset time. This single-center, retrospective cohort study investigated the effectiveness safety of ABT plus dolutegravir (DTG) therapy real-world setting. We performed chart review on electronic patient records PLWHA using DTG between April December 2020....
Abstract Aim The relationship between the gut microbiota, metabolites and body fat percentage (BFP) remains unexplored. We systematically assessed causal relationships BFP using Mendelian randomization analysis. Materials Methods Single nucleotide polymorphisms associated with blood were screened via a genome‐wide association study enrolling individuals of European descent. Summary data from studies extracted MiBioGen consortium UK Biobank. inverse variance‐weighted model was primary method...
Abstract Our recent studies have demonstrated the presence of peptidergic nerve fibers in anterior pituitary rat. They were found to increase number following adrenalectomy and present study was aimed at investigating whether axonal sprouting could account for this increase. Antibody against neuronal growth-associated protein GAP-43 used as probe. Four days GAP-43-like immunoreactivity dramatically, mostly varicosities surrounding gland cells. The results suggest an active hormone...
Microbes play a key role in reef dynamics, mediating the competition between scleractinian corals and benthic algae; however, major shifts bacterial communities among coral species response to increases abundance of algae are not well understood. We investigated taxonomic composition coral-associated microbial under algae-overgrowth conditions using 16S rRNA gene sequencing. The results showed that non-algal (i.e., healthy) tissue (HH) had lower diversity than collected from coral–algae...
β-Glucosidases (3.2.1.21) play essential roles in the removal of nonreducing terminal glucosyl residues from saccharides and glycosides. However, full potential different applications recombinant high-yield microbial β-glucosidase-producing systems remain to be tackled.A β-glucosidase gene designated as Mg132 was isolated a coral microorganism by high-throughput sequencing functional screening. The deduced amino acid sequences showed highest identity 97% with predicted GenBank database. This...
Abstract Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic crisis owing their antimicrobial properties, and human gut biome may be source of these peptides. However, AMPs AMP resistance genes (AMPRGs) microbes in different age groups have not been thoroughly assessed. Here, we investigated development distribution pattern AMPRGs microbiome at ages by analyzing intestinal metagenomic data healthy individuals life stages (CG: centenarians group n = 20; OAG: older...
β-glucosidases can produce gentiooligosaccharides that are lucrative and promising for the prebiotic alternative food industries. However, commercial production of using β-glucosidase is challenging, as this process limited by need high thermal energy increasing demand enzyme. Here, a putative gene, selected from coral microbial metagenome, was expressed in Escherichia coli. Reverse hydrolysis glucose Blg163 at pH 7.0 40 °C achieved gentiooligosaccharide yield 43.02 ± 3.20 g·L−1 conversion...