A5091327358- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Frailty in Older Adults
- Peripheral Artery Disease Management
- Muscle Physiology and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Diagnosis and Treatment of Venous Diseases
- Pain Management and Opioid Use
- Health Systems, Economic Evaluations, Quality of Life
- Opioid Use Disorder Treatment
- Anesthesia and Pain Management
- Body Contouring and Surgery
- Musculoskeletal pain and rehabilitation
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- RNA and protein synthesis mechanisms
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- RNA Research and Splicing
- Aortic aneurysm repair treatments
- Acute Ischemic Stroke Management
- Nutrition and Health in Aging
- Cardiac Health and Mental Health
University of Utah
2020-2024
University of Arizona
2016-2021
This article reports a coupled computational experimental approach to design small molecules aimed at targeting genetic cardiomyopathies. We begin with fully atomistic model of the cardiac thin filament. To this we dock using accepted drug binding methodologies. The candidates are screened for their ability repair alterations in biophysical properties caused by mutation. Hypertrophic and dilated cardiomyopathies mutation initially nature, take is correct insult prior irreversible damage....
An oft noted component of sarcomeric DCM is the observation that patients within families carrying same primary mutation exhibit significant phenotypic variability. This lack a distinct link between genotype and phenotype has complicated clinical management. Recently two unrelated multigenerational were identified with tropomyosin (Tm) Asp230Asn (D230N), exhibiting striking “bimodal” distribution severity. In these families, many children (<1 year) D230N Tm presented severe form led to...
Opioid tapering after surgery is recommended among patients with chronic opioid use, but it unclear how this process affects their quality of life. The objective study was to evaluate following associated patient-reported outcome measures related pain control and behavioral changes that affect