A5019941191- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Congenital Heart Disease Studies
- Central Venous Catheters and Hemodialysis
- Cardiac Structural Anomalies and Repair
- Chronic Kidney Disease and Diabetes
- Potassium and Related Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Pharmacological Effects and Toxicity Studies
- Renal and Vascular Pathologies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Iron Metabolism and Disorders
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Viral Infections and Immunology Research
- Sepsis Diagnosis and Treatment
- ECG Monitoring and Analysis
- Cardiac Fibrosis and Remodeling
- Blood Pressure and Hypertension Studies
- Muscle and Compartmental Disorders
- Liver Disease Diagnosis and Treatment
- Phonocardiography and Auscultation Techniques
University of Colorado Anschutz Medical Campus
2016-2024
University of Colorado Denver
2016-2024
Children's Hospital Colorado
2016-2024
RELX Group (United States)
2017
Acute kidney injury (AKI) defined by changes in serum creatinine (SCr), or oliguria is associated with increased morbidity and mortality children who are critically ill. We derived validated a clinical cutoff value for urine neutrophil gelatinase-associated lipocalin (NGAL), prospective multicenter study of were report the performance NGAL (uNGAL) to aid pediatric AKI risk assessment. Eligible subjects aged ≥ 90 days < 22 years, admitted an intensive care unit (ICU), had 1 more following:...
Background: Both the Norwood procedure and acute kidney injury (AKI) are associated with significant morbidity mortality. The impact of AKI by measured fluid corrected serum creatinine on outcomes after has not been previously studied. purpose this study was to (1) identify incidence AKI, (2) determine risk factors, (3) evaluate in patients using both creatinine. Methods: Single-center retrospective chart review from 2009 2015 including neonates who underwent procedure. Acute defined Kidney...
Background:Reliable prediction of severe acute kidney injury (AKI) and related poor outcomes has the potential to optimize treatment. The purpose this study was modify renal angina index in pediatric cardiac surgery predict AKI outcomes. Methods: We performed a multicenter retrospective with population divided into derivation validation cohort assess performance modified assessed at 8 h after intensive care unit (CICU) admission complex outcome day 3 or (ventilation duration >7 days, CICU...
Severe acute kidney injury (AKI) is associated with subsequent infection. Whether AKI followed by a return to baseline creatinine incident infection unknown.We hypothesized that risk of both short and long term would be higher among patients than in propensity score matched peers without the year following non-infectious hospital admission.Retrospective, cohort study.We identified 494 who were hospitalized between January 1, 1999 December 31, 2009 had creatinine. These controls AKI.The...
Acute kidney injury is a common complication following the Norwood operation. Most neonatal studies report acute peaking within first 48 hours after cardiac surgery. The aim of this study was to evaluate if persistent (>48 postoperative hours) operation associated with clinically relevant outcomes.Two-centre retrospective among neonates undergoing initially identified as developing surgery and stratified into transient (≤48 using modification Kidney Disease: Improving Global Outcomes serum...
Abstract Background Cardiac surgery associated acute kidney injury (CS-AKI) is common. Urine response to loop diuretic and urine neutrophil gelatinase lipocalin (uNGAL) are separately with CS-AKI. We aimed determine whether uNGAL together were postoperative day 2–4 Methods Two-center prospective observational study (ages 0–18 years). (8–12 h after admission) (ng/mL) (6 for bolus furosemide 12 infusion bumetanide) (mL/kg/hr) measured. All doses converted equivalents. The primary outcome was...
Abstract Background: Electrocardiograms are frequently obtained in infants and children. Training specific to paediatric electrocardiogram interpretation is necessary given that cardiac physiology findings children different than adults change throughout infancy childhood. Distributed practice may be an effective method improve residency education efforts. Methods: A pre-survey was administered internal medicine/paediatrics residents ascertain baseline comfort with interpretation....
INTRODUCTION: Previous mortality risk scores for adult cardiac surgery patients did not include congenital heart disease (ACHD) patients. Development of ACHD specific the procedure-specific ACHS score and recently derived PEACH score. While validated in Europe, further evaluation additional settings is necessary. RESEARCH QUESTION: We assessed efficacy to predict undergoing at our institution. compared STS factors which may augment Methods: A retrospective cohort study was conducted who...
Introduction: Despite significant improvements in surgical technique and post-surgical management, mortality remains high for infants with single ventricle congenital heart disease (SV) the ability to risk-stratify SV is limited. microRNAs (miRs) are short regulatory RNAs that modulate gene expression miRs circulation increasingly recognized as valuable biomarkers a broad range of diseases. Hypothesis: Circulating miR profiles prior palliation may correlate survival at one year assist...