A5064806696- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Electron Spin Resonance Studies
- Lipid Membrane Structure and Behavior
- Medical Imaging Techniques and Applications
- Protein Structure and Dynamics
- Lanthanide and Transition Metal Complexes
- Alzheimer's disease research and treatments
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Electrical and Bioimpedance Tomography
- Liver Disease Diagnosis and Treatment
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Hip disorders and treatments
- Body Composition Measurement Techniques
- Weed Control and Herbicide Applications
- MRI in cancer diagnosis
- Water Quality and Resources Studies
- Magnetic and Electromagnetic Effects
- Advanced Neuroimaging Techniques and Applications
- Fungal Plant Pathogen Control
- Archaeology and Natural History
University of Lethbridge
2025
Vanderbilt University
1986-2025
Yale University
2024
University of Aberdeen
2003-2018
University of Kentucky
2014-2017
National Institutes of Health
2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015
Aberdeen Royal Infirmary
1981-2014
DuPont (United States)
1982-1988
City Hospital
1984
Describes a new nuclear magnetic resonance (NMR) imaging technique which the authors call 'spin warp imaging' and gives examples of its application to human whole-body imaging. The apparatus is based on four-coil, air cored magnet (made by Oxford Instrument Company) capable accepting whole body. produces static field 0.04 T giving proton NMR frequency 1.7 MHz. maximum inhomogeneity about 6*10-4 at radius 0.23 m, approximately twice amount theoretically attainable with this configuration....
Using numerical solutions of the Bloch (1946) equations under boundary conditions representing local external magnetic field, and with aid a simple model nuclear spin process, various effects occurring during selective excitation are described. In particular it is shown that in extending technique for one to two dimensions there arises possibility spurious image response, this can be corrected by suitable combination signals from set three sequences. Since two-dimensional selection activates...
Optimizing the perioperative care of patients with a hip fracture is key health-care priority. We aimed to determine whether adherence Scottish Standards Care for Hip Fracture Patients (SSCHFP) was associated improved patient outcomes.In this retrospective cohort study prospectively collected data from National Audit, we assessed SSCHFP in 21 hospitals over 9-month period 2014 and examined effect guidelines on 30 120-day mortality, length hospital stay, discharge destination.A total 1,162...
Automated touchscreen systems have become increasingly prevalent in rodent model screening. This technology has significantly enhanced cognitive and behavioral assessments mice bridged the translational gap between basic research using models human clinical research. Our study introduces a custom-built operant conditioning chamber powered by Raspberry Pi commercially available computer tablet, which effectively addresses significant cost barriers traditionally associated with this...
Helical integral membrane proteins are assumed to require a lipid bilayer or model (e.g. detergent micelles) prevent aggregation and precipitation in aqueous solution. Here, we show that this is not always true single-span helical capable of forming stable but reversible protein nanoparticle assemblies (detergent-limited particles — DLPs) when purified after removal all nearly detergent. Residual DLPs exchangeable with the surrounding This work focuses on formed by transmembrane C-terminal...
The design, construction and use of a large-scale field-cycled proton-electron double-resonance imaging (FC-PEDRI) imager is described. based on whole-body sized, vertical field, 59 mT permanent magnet. Field cycling accomplished by the field compensation method, uses secondary, resistive magnet with an internal diameter 52 cm. magnetic can be switched from zero to or vice versa in 40 ms. It used coil assembly (NMR/EPR) comprising solenoidal NMR transmit/receive coaxial, external birdcage...
The quality of the images produced by nuclear magnetic resonance (NMR) imaging has steadily improved over past five years. Images head, thorax, and abdomen have clearly shown normal anatomy. A clinical trial NMR therefore been started in Aberdeen to assess its diagnostic accuracy compare it with conventional radiography other technique. first patient examined whole-body had carcinoma oesophagus diagnosed on barium meal examination. technetium-99m-sulphur colloid liver scan also showed...
How the distinctive lipid composition of mammalian plasma membranes impacts membrane protein structure is largely unexplored, partly because dearth isotropic model systems that contain abundant sphingolipids and cholesterol. This gap addressed by showing sphingomyelin cholesterol-rich (SCOR) mixtures with phosphatidylcholine can be cosolubilized n-dodecyl-β-melibioside to form bicelles. Small-angle X-ray neutron scattering, as well cryo-electron microscopy, demonstrate these assemblies are...
We describe the design and use of a 48 mm diameter, liquid-helium-cooled MRI receiver coil DC SQUID pre-amplifier. Comparison images non-conducting room temperature test object collected with SQUID-based system those an equivalent-area room-temperature surface show that SNR is approximately factor four greater, despite 15 vacuum gap between sample in case. lower arm also display improved SNRs over coil, this time by two three, as result reveal greater anatomical detail. performance currently...
The tissue levels of paramagnetic ions are an important factor in the determination T1 values as observed by nuclear magnetic resonance (NMR) imaging. increased iron present human disease states such hemochromatosis lead to decreased values. mean liver three patients with storage was determined be 130 msec, significantly different from value 154 for 14 normal controls. Whether NMR will able detect copper and brain Wilson remains further clinical trials evaluate. imaging, however, does serve...
A novel magnetic field and radio frequency (1.7 MHz) pulse sequence is described for a whole body n.m.r. imaging machine under construction. Selective excitation used to obtain signals from successive lines of proton spins (water) across the build up an image transverse section. The images display spin concentration spin-lattice relaxation time, T 1 , separately. For 50 % change in be discerned human trunk, spatial resolution 2 cm 3 expected min scan 0.5 30 scan. Very preliminary at present...
Changes occurring within the seed coat of Cuscuta campestris Yunkr. during desiccation were correlated with a decrease in germinability. Germination initially increased as embryo matured, but then decreased testa dried. Completion macrosclereid development signaled onset dormancy. Mechanical scarification sandpaper or immersion concentrated H 2 SO 4 broke The impermeable layer is region above light line and at junction hypodermis palisade cell layers. This appeared to be deposited...