A5058868191- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Chemokine receptors and signaling
- Peripheral Neuropathies and Disorders
- Regulation of Appetite and Obesity
- Acute Lymphoblastic Leukemia research
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- Herpesvirus Infections and Treatments
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Diseases and Immunity
- Tendon Structure and Treatment
- Cytokine Signaling Pathways and Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
Pfizer (United States)
2018-2022
Metroplex Clinical Research Center
2021
The University of Texas Southwestern Medical Center
2021
Medical University of Vienna
2021
Eli Lilly (United States)
2012-2015
University of California, Los Angeles
2008-2014
Tokyo Women's Medical University
2005-2010
UCLA Health
2008-2009
Hitachi (Japan)
2004
Social Insurance Yokohama Central Hospital
2004
The past few years of research on leptin have provided important information the link between metabolism and immune homeostasis. Adipocytes influence not only endocrine system but also response through several cytokine-like mediators known as adipokines, which include leptin. It is widely accepted that can directly nutritional status pro-inflammatory T helper 1 responses, a decrease plasma concentration during food deprivation lead to an impaired function. Additionally, studies implicated in...
<h3>Objectives</h3> Evaluate efficacy and safety of tabalumab, a human IgG4 monoclonal antibody that binds neutralises membrane soluble B-cell activating factor (BAFF) versus placebo plus standard care (SoC) in patients with systemic lupus erythematosus (SLE). <h3>Methods</h3> This phase III, 52-week study randomised 1164 moderate-to-severe SLE (Safety Estrogens Lupus Erythematosus National Assessment—SLE Disease Activity Index ≥6 at baseline). Patients received SoC subcutaneous injections...
The impact of corticosteroids on the risk organ damage in context clinical end points endorsed some systemic lupus erythematosus (SLE) trials is underexplored.We analysed data from Hopkins Lupus Cohort using Cox proportional hazards models to understand exposure different corticosteroid doses developing any new or at individual systems over time.Mean prior prednisone dose, recent disease activity and immunosuppressant use during follow-up, as well score cohort entry, were significant...
Abstract In systemic lupus erythematosus (SLE), adaptive CD4+CD25+Foxp3+ regulatory T cells (Tregs) suppress Th that help autoantibody (autoAb)-producing B cells. It is not known whether naturally occurring Tregs can directly in SLE without an intermediate suppression of This aspect important for its implications the natural course SLE, because most if all clinical and pathologic effects are associated with a dysregulated production autoAbs. this study, we show inhibit cell activity vitro...
To examine whether a seasonal fluctuation exists with rheumatoid arthritis (RA) activity and to analyse effects of varying components that express disease in RA patients.A group 1665 patients (mean age 57.2 yrs, mean duration 9.9 yrs) whose data were available for 10 consecutive phases from large observational cohort study conducted at our institution October 2000 April 2005, bi-annually, evaluated. Ten criteria analysed assess activity.All revealed decrease during fall increase spring,...
This study aims to reconfirm the clinical efficacy and related factors of infliximab therapy, first biological agent introduced Japanese patients with rheumatoid arthritis (RA). Data 351 RA were collected retrospectively from three major centers for management rheumatic diseases in Japan. Infliximab was infused according approved method, response evaluated following 22 weeks therapy 258 using European League Against Rheumatism (EULAR) criteria. DAS28-CRP (Disease Activity Score including a...
Objective. To compare the sex differences of various components rheumatoid arthritis (RA). Methods. Data 4823 patients from a large observational cohort study were analyzed. Remarkable noted between sexes, and overall, women had significantly higher disease activity. Results. When variables adjusted using sex, age, duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to difference. Further analysis showed evidence that progression disability was...
Fatigue is a hallmark symptom of systemic lupus erythematosus (SLE), often associated with flares, side effects treatment, and extensive organ damage may have significant impact on health-related quality life (HrQoL). To date, the experience fatigue in patients SLE underexplored. This study explored its their lives through qualitative interviews. cross-sectional was conducted 22 adult SLE, recruited from two clinical sites United States. In-person semi-structured interviews were thematic...
Objective To provide the first direct comparison of patient-reported outcomes (PROs) following treatment with tofacitinib monotherapy versus or adalimumab (ADA) in combination methotrexate (MTX) patients rheumatoid arthritis (RA) inadequate response to MTX (MTX-IR). Methods ORAL Strategy ( NCT02187055 ), a phase IIIB/IV, head-to-head, randomised controlled trial, assessed non-inferiority between 5 mg two times per day monotherapy, day+MTX and ADA 40 every other week+MTX. PROs included...
Objective To explore herpes zoster ( HZ ) rates and live vaccine LZV safety in a subset of patients with rheumatoid arthritis who received before tofacitinib ± methotrexate MTX ), or adalimumab ADA plus the ORAL Strategy. Methods Strategy was 1‐year, phase IIIb/IV, randomized, triple‐dummy, active‐comparator–controlled study. ‐inadequate responder 5 mg twice daily (BID), BID , 40 every other week (1:1:1 randomization). Eligible age ≥50 years could opt to receive 28 days initiating study...
<b>Background:</b> An imbalance in cytokine homoeostasis is thought to have a key role the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE), and recently, for chemokines has been noted. <b>Objective:</b> To compare concentrations monocyte chemotactic protein-1 (MCP-1)/CCL2 cerebral spinal fluid (CSF) patients with SLE, without symptoms. <b>Methods:</b> CSF was obtained from 185 SLE: 96 NPSLE 89 SLE symptoms (non-NPSLE patients). MCP-1/CCL2 were measured an ELISA....
The purpose of this study was to evaluate the effects L-4F, an apolipoprotein A-1 mimetic peptide, alone or with pravastatin, in apoE-/-Fas-/-C57BL/6 mice that spontaneously develop immunoglobulin G (IgG) autoantibodies, glomerulonephritis, osteopenia, and atherosclerotic lesions on a normal chow diet. Female mice, starting at eight nine weeks age, were treated for 27 1) 2) 3) L-4F plus 4) vehicle control, followed by disease phenotype assessment. In preliminary studies, dysfunctional,...
We conducted a retrospective, clinical evaluation of connective tissue disease (CTD) patients who were tested for either sputum or bronchoalveolar lavage fluid Pneumocystis polymerase chain reaction (PC-PCR) and analyzed the risk factors that cause pneumonia (PCP) susceptibility fatality. PC-PCR was performed on 66 CTD presented with symptoms, data, radiological findings strongly suggesting respiratory infection. Patients higher oral corticosteroid doses, use methotrexate (MTX), bilateral...
This study aims to reconfirm the clinical efficacy and related factors of infliximab therapy, first biological agent introduced Japanese patients with rheumatoid arthritis (RA). Data 351 RA were collected retrospectively from three major centers for management rheumatic diseases in Japan. Infliximab was infused according approved method, response evaluated following 22 weeks therapy 258 using European League Against Rheumatism (EULAR) criteria. DAS28-CRP (Disease Activity Score including a...
Objective: The primary aim of this study was to investigate the association polymorphisms TRAF1-C5 , a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility RA and systemic lupus erythematosus (SLE) Japanese populations. Gene expression levels TRAF1 C5 assess functional significance genotypes were also analysed. Methods: A multicentre consisting 4 case-control series (4397 cases 2857 controls) 3 SLE (591 2199 shared conducted. Genotyping performed using...
Atherosclerosis is accelerated in people with systemic lupus erythematosus, and the presence of dysfunctional, pro-inflammatory high-density lipoproteins a marker increased risk. We developed mouse model multigenic exposed to environmental factors known accelerate atherosclerosis humans — high-fat diet or without injections adipokine leptin. BWF1 mice were lupus-prone model; BALB/c non-autoimmune controls. High-fat total serum cholesterol both strains. In mice, non-high-density lipoprotein...
In systemic lupus erythematosus (SLE), the availability of self-antigen promotes and fuels self-reactive immune responses. Apoptotic cells represent a major source self-antigens, an impairment removal apoptotic material containing can contribute to development autoimmunity. To address whether adipocytokine leptin--which favors autoimmune responses through little understood mechanisms--could modulate handling in SLE, we evaluated ability leptin capacity macrophages phagocytose bodies (NZB ×...
Abstract To prevent autoimmunity, anergy of autoreactive B cells needs to be maintained, together with the suppression hyperactive cells. We previously reported that CD4+CD25+Foxp3+ regulatory T (Tregs) can directly suppress autoantibody-producing in systemic lupus erythematosus. In this article, we show Tregs also reduce production autoantibodies (NZB × NZW)F1 mouse by promoting cell anergy, both vitro and vivo. This phenomenon associated a reduction Ca2+ flux cells, CTLA-4 blockade...
Objectives. To study the role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 in pathogenesis rheumatoid arthritis (RA), we analysed expression MCP-4/CCL13 chondrocytes, synovial fluid and serum from patients with RA investigated effect on proliferation cells.
We conducted a retrospective, clinical evaluation of connective tissue disease (CTD) patients who were tested for either sputum or bronchoalveolar lavage fluid Pneumocystis polymerase chain reaction (PC-PCR) and analyzed the risk factors that cause pneumonia (PCP) susceptibility fatality. PC-PCR was performed on 66 CTD presented with symptoms, data, radiological findings strongly suggesting respiratory infection. Patients higher oral corticosteroid doses, use methotrexate (MTX), bilateral...