A5050610166- Ovarian function and disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Genetic Syndromes and Imprinting
- Diabetes Treatment and Management
- Sexual Differentiation and Disorders
- RNA modifications and cancer
- LGBTQ Health, Identity, and Policy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Diabetic Foot Ulcer Assessment and Management
- Ovarian cancer diagnosis and treatment
- Nuclear Structure and Function
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Orthopedic Surgery and Rehabilitation
- Growth Hormone and Insulin-like Growth Factors
- Child Nutrition and Feeding Issues
- Infectious Diseases and Tuberculosis
- Pharmacology and Obesity Treatment
- Congenital Diaphragmatic Hernia Studies
- Pituitary Gland Disorders and Treatments
University of Missouri–Kansas City
2019-2024
Children's Mercy Hospital
2018-2024
Abstract Introduction Polycystic ovary syndrome (PCOS) is a heterogenous clinical defined by hyperandrogenism and irregular menses. In adult women with PCOS, discrete metabolic reproductive subgroups have been identified. We hypothesize that distinct phenotypes can be distinguished between adolescent girls who are lean (LN-G) obesity (OB-G) at the time of PCOS diagnosis. Methods Data were extracted from CALICO multisite database. Clinical data collected diagnosis available in 354 patients...
The objective of our study was to describe the prevalence gender diverse (GD) youth among adolescents with polycystic ovary syndrome (PCOS).We conducted a retrospective chart review on patients who met NIH criteria for PCOS in Multidisciplinary Adolescent Program (MAPP). We compared those MAPP did not meet as well non-PCOS from Specialty Clinic (ASC). Variables analyzed included identity, androgen levels, hirsutism scores, and mood disorders. used chi-square, Fisher's exact, t-tests,...
Hypoglycemia is concerning for neurological complications in infants and children. Determining the cause of hypoglycemia essential providing appropriate treatment. Hyperinsulinism growth hormone deficiency are known causes but not commonly found together. We report a 4-month-old boy who presented with severe was to have both hyperinsulinism deficiency. Treatment recombinant human diazoxide led blood glucose normalization. Subsequently, he genetic diagnosis 20p11.22p11.21 deletion. 20p11...
Type A insulin resistance (IR) is caused by heterozygous mutations in the receptor gene. It presents with mild acanthosis nigricans, severe IR, and hyperandrogenism absence of obesity or lipodystrophy. Treatment aims to improve sensitivity decrease androgens. An adolescent girl was evaluated for secondary amenorrhea prominent hirsutism. She had a normal body mass index, laboratory testing revealed an elevated LH FSH ratio (LH 11.6 mIU/mL, 4.2 mIU/mL), testosterone 96 ng/dL (reference range...
We studied longitudinal differences between progressors and nonprogressors to type 1 diabetes with similar substantial baseline risk.Changes in 2-h oral glucose tolerance test indices were used examine variability progression the Diabetes Prevention Trial-Type (DPT-1) study (n = 246) Type TrialNet Pathway (TNPTP) 503) among autoantibody (Ab)+ children (aged <18.0 years) metabolic impairment (DPT-1 Risk Score [DPTRS] of 6.5-7.5), as well TNPTP Ab- 94).Longitudinal analyses revealed annualized...
Abstract Background Many barriers exist to the appropriate recognition and management of life-threatening adrenal crisis in emergency department (ED). Clinical decision support (CDS) is a health information technology (IT) component that provides useful providers as healthcare being delivered. We hypothesized CDS incorporated into electronic record (EHR) could improve within pediatric ED. Methods retrospectively analyzed impact on patients with known insufficiency (AI) presenting two ED...
Purpose: Several studies demonstrate endogenous androgen excess in adult trans male patients, but data are lacking adolescents. Identifying hyperandrogenism growing children is relevant, as it can be the first sign of serious adrenal conditions and associated with advanced skeletal maturity premature growth cessation. We sought to identify percentage adolescent patients who, prior gender affirming treatment, have biochemical relative reference ranges a comparison group.
Abstract Introduction Hyperinsulinism (HI) and growth hormone deficiency (GHD) are known causes of hypoglycemia but not commonly found together. We present a 4-month-old boy with to have both HI GHD subsequent genetic diagnosis 20p11 deletion. This deletion has been associated panhypopituitarism. case represents few report as manifestation this Treatment recombinant human (rhGH) Diazoxide led blood glucose (BG) normalization. Clinical Case A 4-month-old, full-term, large for gestational age...
Abstract Background: Pediatric type 2 diabetes (T2D) has increased in prevalence as childhood obesity rates climb. More youth are being referred to pediatric endocrinology due the concern for developing T2D, yet prediction of which children will progress overt T2D is challenging. We describe a single center experience with prediabetes referrals and trends HbA1c change. Methods: Retrospective review new patients seen at Type Diabetes Prevention (T2DP) Clinic July 2015 - December 2019. All...
Abstract Disclosure: G.S. Babar: None. E.C. Wee: E. Paprocki: T. Luetjen: Y. Yan: BACKGROUND: COVID-19 pandemic changed lifestyles of children. To prevent the spread virus, school closures with virtual learning, suspension organized sports and social distancing were implemented.Objective: assess impact on children including circumstances, eating behaviors, physical activity, emotional responses in families between ages 5-12 years. Design/Methods: After verbal consent an IRB approved survey...
1. Megan Ference, MD* 2. Emily Paprocki, DO* 3. Jennifer Boyd, DO* 4. David F. Butler, MD* 5. Denise Bratcher, DO† 1. *Department of Pediatrics, Children’s Mercy Hospital, Kansas City, MO 2. †Department Division Infectious Diseases, MO A previously healthy, unimmunized 5-year-old boy is found to have apnea, muscle rigidity, and trismus when paramedics arrive at his home. He has severe arching back, with only head buttocks touching the gurney. Symptoms began an intermittent dry cough...
Background: Type A insulin resistance (IR) is a form of severe IR due to heterozygous mutations in the receptor gene. It presents with acanthosis nigricans, IR, and hyperandrogenism absence obesity or lipodystrophy. Treatment aims decrease androgens improve sensitivity. We describe first adolescent patient having successful resolution clinical biochemical during GnRH agonist treatment. Clinical Case: An female was referred for secondary amenorrhea hirsutism. She had normal BMI prominent...
Polycystic ovary syndrome (PCOS) is a female metabolic disorder that characterized by ovulatory dysfunction, elevated serum androgen concentrations, and polycystic ovarian morphology (PCOM). However, diagnosis of PCOS in adolescents challenging.The mechanisms pathophysiology are discussed include: i) dysregulation the levels steroidal enzymes ii) abnormalities secretion gonadotropin releasing hormone, luteinizing follicle stimulating hormone , iii) Thecal Granulosa cell function. Current...