A5059979258- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Liquid Crystal Research Advancements
- nanoparticles nucleation surface interactions
- Insect and Pesticide Research
- Insect-Plant Interactions and Control
- Photochromic and Fluorescence Chemistry
- Plant and animal studies
- Machine Learning in Materials Science
- Material Dynamics and Properties
- Mathematical and Theoretical Epidemiology and Ecology Models
- HER2/EGFR in Cancer Research
- Metal-Organic Frameworks: Synthesis and Applications
- Evolution and Genetic Dynamics
- Crystal structures of chemical compounds
- Fish Ecology and Management Studies
- Histone Deacetylase Inhibitors Research
- Solid-state spectroscopy and crystallography
- Advanced Materials and Mechanics
- Block Copolymer Self-Assembly
- Protein Degradation and Inhibitors
- Synthesis and Properties of Aromatic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
New York University
2019-2024
Pfizer (United States)
2024
University of Abou Bekr Belkaïd
2012
Imidacloprid, the world's leading insecticide, has been approved recently for controlling infectious disease vectors; yet, in agricultural settings, it implicated frightening decline of pollinators. This argues strategies that sharply reduce environmental impact imidacloprid. When used as a contact effectiveness imidacloprid relies on physical between its crystal surfaces and insect tarsi. Herein, seven new polymorphs are reported, adding to two known forms. Anticipating uptake molecules...
Crystallization outcomes, polymorph stability rankings, and phase transformation pathways can be significantly altered when crystallization is restricted to dimensions below 1 μm. In this review, we discuss the state of art polymorphism in nanoconfinement. A primer presented regarding prevalent theories for nucleation, their implications nucleation confinement, dependence solubility on crystal size. The various methods discovery control polymorphs are reviewed. Polymorphism under...
Two new metastable polymorphs of the tuberculosis drug isoniazid, considered monomorphic for sixty years, were discovered using melt crystallization and nanoscale confinement.
Benzamide, a simple derivative of benzoic acid and common intermediate pharmaceutical compounds, was reported to form two polymorphs in 1832, but the single crystal structure more stable not solved until 1959. Nearly 50 years later, second characterized by powder diffraction, followed shortly thereafter characterization third form, polytype most thermodynamically Form I. These new forms, Forms II III, are metastable. Herein, we describe fourth polymorph, IV, discovered melt crystallization...
The crystallization of nicotinamide (NA) and its constitutional isomer, isonicotinamide (INA), is compared. NA formed eight polymorphs from the melt two solution, whereas INA six solution. This analysis was provoked by observation that highly polymorphic melt, while closely related polymorphous A combination hot stage polarized light microscopy, powder X-ray diffraction, Raman spectroscopy revealed polymorph selectivities are not to supramolecular self-association in growth media. larger...
A commercial process for vepdegestrant (1), the most advanced PROTAC protein degrader in human clinical trials, has been developed to support and needs. The features an efficient convergent synthetic strategy through final reductive amination of two chiral intermediates, as well several highly telescoped processes robust crystallization purity control. (1) consists seven proposed regulatory GMP steps with five isolations overall yield 29%.
Flufenamic acid (FFA) is a highly polymorphic compound, with nine forms to date. When melt crystallization was performed under nanoscale confinement in controlled pore glass (CPG), the formation of extremely unstable FFA form VIII favored. Under confinement, sufficiently stable allow measurement its melting point, which decreased decreasing size accord Gibbs–Thomson relationship, enabling determination otherwise elusive point bulk form. Moreover, transformation pathways among various...
The growth of spontaneously twisted crystals is a common but poorly understood phenomenon. An analysis the formation metastable benzamide polymorph (form II) crystallizing from highly supersaturated aqueous and ethanol solutions given here. Benzamide, first polymorphic molecular crystal reported (1832), would have been helicoidal observed had original authors undertaken an by light microscopy. Polymorphism twisting frequently concur as they are both associated with high thermodynamic driving...
Crystallization from the melt can allow achievement of high driving force for crystallization accompanied by relatively slow growth, nucleation, and transformation rates, features that favor its use as an efficient polymorph screening method. Surprisingly, even though has a long history, it been employed less often in search new polymorphs than solution crystallization. Applications to 21 highly polymorphic, well-characterized compounds with at least five ambient revealed afforded more half...
Abstract The growth of spontaneously twisted crystals is a common but poorly understood phenomenon. An analysis the formation metastable benzamide polymorph (form II ) crystallizing from highly supersaturated aqueous and ethanol solutions given here. Benzamide, first polymorphic molecular crystal reported (1832), would have been helicoidal observed had original authors undertaken an by light microscopy. Polymorphism twisting frequently concur as they are both associated with high...
Disorder is a common feature of molecular crystals that complicates determination structures and can potentially affect electric mechanical properties. Suppression disorder observed in otherwise severely disordered benzamide thiobenzamide by substituting hydrogen with fluorine the
Tuberculosis (TB) is a disease that has thousands of years history. 1 This epidemic caused by bacillus Mycobacterium tuberculosis used to be fatal until effective chemotherapy appeared in the 1940s. 2 For now, there are 20 TB drugs clinical trials and lot efforts invested into research about prevention treatment TB.Yet, "end" as major health problem still unreachable.According Global Report 2018, "TB one top 10 causes death". 3Intensified known anti-tubercular effort design new urgently...