A5003227116- Antibiotics Pharmacokinetics and Efficacy
- Helminth infection and control
- Microbial infections and disease research
- Essential Oils and Antimicrobial Activity
- Antibiotic Resistance in Bacteria
- Animal Nutrition and Physiology
- Coccidia and coccidiosis research
- Pharmacological Effects and Assays
- Veterinary medicine and infectious diseases
- Bee Products Chemical Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Insect and Pesticide Research
- Meat and Animal Product Quality
- Pesticide Residue Analysis and Safety
- Milk Quality and Mastitis in Dairy Cows
- Insect Pest Control Strategies
- Probiotics and Fermented Foods
- Trypanosoma species research and implications
- Veterinary Pharmacology and Anesthesia
- Antimicrobial Peptides and Activities
- Aquaculture disease management and microbiota
- Mycobacterium research and diagnosis
- Agricultural safety and regulations
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
Universidad Nacional de La Plata
2012-2024
Roche Pharma AG (Germany)
2023
Centro Científico Tecnológico - Tucumán
2021
Instituto de Genética Veterinaria
2014
The close contact between dogs and humans creates the best bridge for interspecies transmission of antimicrobial-resistant bacteria. surveillance its resistance including detection extended-spectrum beta-lactamases (ESBLs) in Escherichia coli as indicator bacteria is an important tool to control use antimicrobials. aim this research was evaluate E. strains by phenotypic methods, isolated from pet stray La Plata city, Argentina. Faecal samples were collected using rectal swabs 50 with owners...
The emergence of resistance to antibiotics has been favored by abuse in the application antimicrobials human and animal medicine. Essential oils are a great resource deal with this crisis. Melaleuca armillaris belongs family Myrtaceae, rich species essential oils. Plant extracts shown antimicrobial activity many investigations. Cloxacillin (CLOX) is an antibiotic widely used veterinary medicine against Staphylococcus aureus. Our aim was assess pharmacodynamic interaction established...
Little is known about the ecology of critically important antibiotic resistance among bacteria with potential to be opportunistic human pathogens (e.g., Escherichia coli ) on South American farms. By studying 70 pig and dairy cattle farms in central-eastern Argentina, we identified that third-generation cephalosporin (3GC-R) E. was mediated by mechanisms seen more often certain species 3GC-R were likely co-resistant florfenicol amoxicillin/clavulanate. This suggests on-farm usage key...
Bioactive glasses have been proposed for bone tissue engineering due to their excellent biocompatibility and osteo-inductive behaviour. The generation of mesoporous bioactive glass (nano) particles adds a high surface area the dissolution release ions, possibility load them with different drugs antibacterial purposes. Essential oils (EO) are an interesting resource alternative medical therapy, providing antimicrobial compounds that come from organic/natural resources like aromatic plants....
The serum and synovial pharmacokinetics of amoxycillin (AMX) were studied after i.v. administration at a dosage 40 mg/kg to normal horses with induced aseptic carpal arthritis. best estimates pharmacokinetic parameters calculated by mono or bivariable non‐linear regression analysis. A biexponential equation was used describe the concentration vs. time profiles in both arthritic horses. There no kinetic differences between were, however, major changes these groups. rate penetration from fluid...
Essential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models useful describing the growth, survival, and inactivation of microorganisms antimicrobials. We evaluated activity Melaleuca armillaris EO obtained from plants placed province Buenos Aires (Argentina) Staphylococcus aureus. The minimum inhibitory bactericidal concentrations were close decreased, slightly acidifying medium pH 7.4 to 6.5 5.0. This result was also evidenced by...
The pharmacokinetics of ricobendazole (RBZ) and its major metabolite albendazole sulphone (ABZSO2) were studied in six calves, after administration RBZ (7.5 mg/kg), using a 10% experimental solution by the intravenous (i.v.) route, commercial subcutaneous (s.c.) suspension intraruminal (i.r.) route. Blood samples drawn during 60-h period. Plasma drug concentrations determined HPLC. pharmacokinetic evaluation each case was prepared weighted least-squares nonlinear regression analysis....
The disposition of enrofloxacin in sheep was investigated after single-dose intravenous administration 2.5 mg/kg body weight. Blood samples were drawn from the jugular vein at predetermined times drug administration. Plasma concentrations and its active metabolite ciprofloxacin simultaneously determined by reverse-phase high performance liquid chromatography. data collected subjected to non-compartmental compartmental kinetic analysis. Statistical model theory used determine pharmacokinetic...
Staphylococcus aureus frequently causes subclinical mastitis around the world with a high impact on milk industry and public health. Essential oils (EO) are recognized antimicrobials that can be synergistic antibiotics. The main objective of this study was to evaluate essential oil Melaleuca armillaris as an adjuvant erythromycin (ERY) for alternative treatment bovine caused by S. . Minimum Inhibitory Bactericidal Concentrations (MIC MBC) EO, ERY, its combinations were established against at...
The objective of this study was to evaluate the interaction efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine (NMP) when combined with different families antimicrobial agents against isogenic strains and multidrug-resistant (MDR) Escherichia coli field isolated from animals. Laboratory E. levels expression pumps were used as quality controls. Ten MDR collected healthy animals in a cross-sectional four commercial dairy farms. MICs florfenicol, ciprofloxacin, tetracycline ampicillin...
Staphylococcus aureus is the major subclinical mastitis-causing pathogen in dairy cows. In some European and Latin American countries rifaximin (RIF) a commonly used therapy at drying off. Phytotherapeutics are alternatives for treatment of infectious diseases. Melaleuca armillaris essential oil (EO) has been reported as good antimicrobial against S. aureus. The aim this work was to investigate, vitro, combined effect EO RIF identify synergic interaction aureus, order obtain sufficient...
Azithromycin is a time-dependent antimicrobial with long persistence. The main characteristics of azithromycin suggest that it could be useful for treating bovine mastitis caused by Staphylococcus aureus. To investigate this possibility, its pharmacokinetic (PK) behavior was studied. Six Holstein lactating cows subclinical were administered two 10 mg/kg intramuscular (i.m.) doses azithromycin, 48-h interval. Milk and plasma concentrations measured microbiological assay. MIC(90) determined in...
Helminth infections are widespread in the poultry industry. There is evidence of extra-label use some drugs, such as ivermectin (IVM), broiler poultry. Pharmacokinetic and residual studies IVM poultry, however, rather scarce. Our aim was to determine time restrictions for chickens fed with balanced feed mixed 21 days, thus achieve acceptable levels consumption established by European Union. Sixty 1-day-old chicks were food supplemented at 5 mg kg–1 days. Groups six treated animals sacrificed...
Triatoma infestans is the principal vector of Trypanosoma cruzi, parasite responsible Chagas´s Disease transmission in Argentina. Pyrethroids have become common pesticides for control T. but increasing resistance encourages search new alternatives and use natural products biological arises as a strategy. Melia azedarach L. originated from Himalaya´s region several compounds are part its rich phytochemistry. Folk medicine plant due to repellent insecticidal activities. Aims this work were...
Eight male cattle were given a combined dose containing 20 mg/kg oxytetracycline and 0.5 diclofenac intramuscularly. Blood samples drawn at different times until 168 h after administration. Two experimental animals slaughtered by humane means weekly intervals up to 28 days Samples of muscle, injection zone tissue, liver, kidney fat obtained. Oxytetracycline concentrations determined high performance liquid chromatography. Kinetic analysis was performed linear regression using the CSTRIP...