A5042322444- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Heat shock proteins research
- Redox biology and oxidative stress
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Plant biochemistry and biosynthesis
- Cancer, Lipids, and Metabolism
- Curcumin's Biomedical Applications
- Enzyme Catalysis and Immobilization
- Retinoids in leukemia and cellular processes
- Lipid Membrane Structure and Behavior
- RNA regulation and disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Autophagy in Disease and Therapy
- Nanoparticle-Based Drug Delivery
Universidad de Zaragoza
2022-2025
Instituto de Investigación Sanitaria Aragón
2022-2024
Centro de Investigación y Tecnología Agroalimentaria de Aragón
2023-2024
Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Université de Pau et des Pays de l'Adour
2023-2024
Institut des Sciences Analytiques
2024
Islamic Azad University Medical Branch of Tehran
2023
Islamic Azad University, Tehran
2023
Virgin olive oil, the main source of fat in Mediterranean diet, contains a substantial amount squalene which possesses natural antioxidant properties. Due to its highly hydrophobic nature, bioavailability is reduced. In order increase delivery and potentiate actions, has been loaded into PLGA nanoparticles (NPs). The characterization resulting was assessed by electron microscopy, dynamic light scattering, zeta potential high-performance liquid chromatography. Reactive oxygen species (ROS)...
Cellular stressors have been demonstrated to exert a substantial influence on the functionality of organelles, thereby impacting cellular homeostasis and contributing development disease pathogenesis. This review aims examine impact diverse stressors, including environmental, chemical, biological, physical factors, critical organelles such as cell membrane, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, membrane-less organelles. The intricate molecular mechanisms underlying...
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is influenced by a number variables, including endoplasmic reticulum stress (ER). Thioredoxin domain-containing 5 (TXNDC5) member the protein disulfide isomerase family and acts as an (ER) chaperone. Nevertheless, function TXNDC5 in hepatocytes under ER remains largely uncharacterized. In order to identify role hepatic wild-type (WT) TXNDC5-deficient (KO) AML12 cell lines, tunicamycin, palmitic acid, thapsigargin were employed...
Non-alcoholic fatty liver disease or steatosis is an accumulation of fat in the liver. Increased amounts non-esterified acids, calcium deficiency, insulin resistance may disturb endoplasmic reticulum (ER) homeostasis, which leads to abnormal misfolded proteins, activating unfolded protein response. The ER primary location site for chaperones like thioredoxin domain-containing 5 (TXNDC5). Glutathione participates cellular oxidative stress, and its interaction with TXNDC5 decrease disulfide...
Hepatic thioredoxin domain-containing 5 (TXNDC5) is a member of the protein disulfide isomerase family found associated with anti-steatotic properties squalene and located in endoplasmic reticulum lipid droplets. Considering that latter are involved hepatic accumulation, present research was aimed to investigate role TXNDC5 on management mice AML12 cell line. Wild-type TXNDC5-deficient (KO) were fed Western diets or without 1% supplementation for 6 weeks. In males, but not females, absence...
Squalene, a triterpene found in extra virgin olive oil, has therapeutic properties diseases related to oxidative stress, such as cancer. However, its hydrophobic nature and susceptibility oxidation limit bioavailability outside of oil. To expand applications, alternative delivery methods are necessary. The objective the present study was examine impact squalene encapsulated PLGA (poly(lactic-co-glycolic) acid) nanoparticles (PLGA + Sq) on proliferation human colon carcinoma Caco-2 cells,...
Squalene is the major unsaponifiable component of virgin olive oil, fat source Mediterranean diet. To evaluate its effect on hepatic transcriptome, RNA sequencing was carried out in two groups male Large White x Landrace pigs developing nonalcoholic steatohepatitis by feeding them a high fat/cholesterol/fructose and methionine choline-deficient steatotic diet or same with 0.5% squalene. Hepatic lipids, squalene content, steatosis, activity (ballooning + inflammation), SAF (steatosis...
Abstract Background: One of the important molecular pathways in breast cancer is PTEN-PI3K-AKT pathway. Any change activity PTEN gene can alter PI3K-AKT Moreover, there are subsets genes and their expression changes by post-transcriptional regulations. For instance, regulation alters non-coding RNAs such as micro-RNAs regulators that prevent target transcript. Therefore, it essential to assess related alterations micro-RNA patterns find out possible causes conversions transcripts...
Abstract Background: Aberrant promoter methylation of CpG islands is an important mechanism for regulation gene expression. Recent data suggest that epigenetic abnormalities may occur very early in lung carcinogenesis. Systemic changes be a diagnostic marker tumor development or prognosis. In this study, the expression and KMT2D IGF2 genes were investigated cancer tissue compared to adjacent normal tissue. Methods: The status 30 patients with NSCLC after genomic DNA extraction using...
The Mediterranean diet is a well-known dietary pattern that has gained considerable popularity worldwide for its ability to prevent the progression of nonalcoholic fatty liver disease. This largely attributed use virgin olive oil as primary source fat, which contains substantial amount squalene, natural antioxidant. In order enhance delivery squalene and amplify effects due highly hydrophobic nature, herein, been incorporated into chitosan nanoparticles. characterization resulting...
Abstract Background Alzheimer's disease is described as a structural and functional disorder of the human brain its prevalence increasing among middle-aged communities. Inflammation one most important key factors in development Alzheimer's. IL-33, multifunctional cytokine, can play significant role Alzheimer's-induced inflammation. This study was performed to evaluate anti-inflammatory properties propolis On IL-33 gene expression. It also designed observe effect on memory learning groups...
One of the important molecular pathways in breast cancer is PTEN-PI3K-AKT pathway. Any change activity PTEN gene can alter PI3K-AKT Moreover, there are subsets genes and their expression changes by post-transcriptional regulations. For instance, regulation alters non-coding RNAs such as micro-RNAs regulators that prevent target transcript. Therefore, it essential to assess related alterations micro-RNA patterns find out possible causes conversions transcripts PTENPI3K-AKT pathway cancer.To...