A5050991620- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Metal-Organic Frameworks: Synthesis and Applications
- Computational Drug Discovery Methods
- Veterinary medicine and infectious diseases
- Enzyme Structure and Function
- Crystallography and molecular interactions
- Machine Learning in Materials Science
- Polymer Synthesis and Characterization
- Phenothiazines and Benzothiazines Synthesis and Activities
- Steroid Chemistry and Biochemistry
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Metabolomics and Mass Spectrometry Studies
Adam Mickiewicz University in Poznań
2021-2025
In the search for new bioactive compounds, a methodology based on combining two molecules with biological properties into hybrid molecule was used to design and synthesize of series ten indole derivatives bearing imidazole, benzothiazole-2-thione, or benzoxazole-2-thione moieties at C-3 position. The compounds were spectroscopically characterized tested their antioxidant, antibacterial, fungicidal activities. crystal structures determined five them. Comparison closely related containing...
The search for new biologically active compounds with prospective pharmaceutical applications has motivated the investigation of alternative synthesis pathways. One such approach involves development established biological activity as lead compounds. focus on natural origin is gaining prominence, steroids and alkaloids representing notable examples. Our research aimed to synthesize novel steroid–alkaloid bioconjugates potential activity. structure all was determined using spectroscopic...
The ability of the indole-imidazole hybrid ligands to coordinate with Zn(II) ion and resulting structures this new class coordination compounds were analyzed in order determine their structural properties biological functionalities. For purpose, six novel complexes, [Zn(InIm)2Cl2] (1), [Zn(InMeIm)2Cl2] (2), [Zn(IniPrIm)2Cl2] (3), [Zn(InEtMeIm)2Cl2] (4), [Zn(InPhIm)2Cl2] (5) [Zn2(InBzIm)2Cl2] (6) (where InIm is 3-((1H-imidazol-1-yl)methyl)-1H-indole), synthesized by reactions ZnCl2...
Alkaloids are natural compounds useful as scaffolds for discovering new bioactive molecules. This study utilized alkaloid gramine to synthesize two groups of C3-substituted indole derivatives, which were either functionalized at N1 or not. The characterized by spectroscopic methods. protective effects the against in vitro oxidative hemolysis induced standard oxidant 2,2′-azobis(2-amidinopropane dihydro chloride (AAPH) on human erythrocytes a cell model investigated. Additionally, screened...
Artificial intelligence (AI) is widely explored nowadays, and it gives opportunities to enhance classical approaches in QSAR studies. The aim of this study was investigate the cytoprotective activity parameter under oxidative stress conditions for indole-based structures, with ultimate goal developing AI models capable predicting generating novel compounds. We propose a new system suggesting chemical structures based on some known activity. Cytoprotective prediction models, employing...