A5013944333- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Synthesis and biological activity
- Herpesvirus Infections and Treatments
- Eicosanoids and Hypertension Pharmacology
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- interferon and immune responses
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Parvovirus B19 Infection Studies
- Fungal Infections and Studies
Aarhus University
2020-2021
Aarhus University Hospital
2017-2021
Abstract Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from patients. Further, uncover agonists 4-octyl-itaconate (4-OI) clinically approved dimethyl fumarate (DMF) induce a cellular antiviral program potently inhibits replication SARS-CoV2 across cell lines. The inhibitory effect...
Autophagy defects predispose to recurrent HSV2 meningitis and reveal an important role for autophagy in antiviral immunity.
Paralytic poliomyelitis is a rare disease manifestation following poliovirus (PV) infection. The determinants remain largely unknown. We used whole exome sequencing to uncover possible contributions of host genetics the development outcome in humans with poliomyelitis. identified patient variant ATG7, an important regulatory gene macroautophagy/autophagy pathway. PV infection did not induce prominent type I interferon response, but rather activated autophagy neuronal-like cells, and this was...
Abstract IFN-γ–inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP–AMP synthase–stimulator of IFN genes pathway. Because mice do not have a clear ortholog IFI16, this system suitable for genetic studies IFI16. In study, we compared dependency on synthase, and stimulator type I induction by panel pathogenic bacteria viruses. The response induced HSV-2 was particularly dependent cohort patients with genital herpes healthy controls, minor G allele IFI16...
Abstract Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that NRF2 anti-oxidant gene expression pathway is suppressed in biopsies obtained from patients. Further, uncover agonists 4-octyl-itaconate (4-OI) clinically approved dimethyl fumarate (DMF) induce a potent cellular anti-viral program, which potently inhibits replication SARS-CoV2 across cell lines. The...
Recurrent lymphocytic meningitis, also referred to as Mollaret is a rare neurological disease characterized mainly by reactivation of herpes simplex virus 2 (HSV-2) from sensory ganglia. However, the underlying host immune determinants and viral factors rendering some individuals unable maintain HSV-2 latency are largely unknown. We collected cohort 15 patients diagnosed with meningitis. By whole-exome sequencing we identified genetic variants predicted be deleterious in molecules involved...
The present study describes a 19-year-old woman with systemic herpes simplex virus (HSV)-1 infection and hemophagocytic lymphohistiocytosis (HLH) postpartum, fatal course of neonatal herpesvirus infection. Functional investigation cells from the mother demonstrated significantly impaired induction antiviral interferons cytokines in context normal activation transcription factors NF-κB IRF3. Whole-exome sequencing did not reveal any functionally validated genetic variants. We suggest that...
Abstract Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here we demonstrate that NRF2 anti-oxidant gene expression pathway is suppressed in biopsies obtained from patients. Further, uncover agonists 4-octyl-itaconate (4-OI) clinically approved dimethyl fumarate (DMF) induce a cellular anti-viral program, which potently inhibits replication SARS-CoV2 across cell lines. The program...