A5016045810- Carcinogens and Genotoxicity Assessment
- Potato Plant Research
- Effects and risks of endocrine disrupting chemicals
- Plant Pathogens and Resistance
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Sulfur Compounds in Biology
- Pesticide Exposure and Toxicity
- Analytical Chemistry and Chromatography
- Porphyrin Metabolism and Disorders
- Birth, Development, and Health
- Radiation Effects and Dosimetry
- Chemical Safety and Risk Management
- DNA Repair Mechanisms
- Pesticide Residue Analysis and Safety
- Glutathione Transferases and Polymorphisms
- Air Quality Monitoring and Forecasting
- Amino Acid Enzymes and Metabolism
- Advanced Chemical Sensor Technologies
- Nutrition, Genetics, and Disease
- Acute Lymphoblastic Leukemia research
- Pharmacogenetics and Drug Metabolism
Stockholm University
2015-2024
Maastricht University
2012
Norwegian Institute of Public Health
2012
BioDetection Systems (Netherlands)
2012
Genedata (Switzerland)
2012
Swedish Veterinary Agency
2010
Newcastle University
2000-2009
Medical University of Warsaw
2009
Instytut Zywnosci Zywienia
2009
Karolinska Institutet
2001-2008
Reaction products (adducts) of acrylamide with N termini hemoglobin (Hb) are regularly observed in persons without known exposure. The average Hb adduct level measured Swedish adults is preliminarily estimated to correspond a daily intake approaching 100 μg acrylamide. Because this uptake rate could be associated considerable cancer risk, it was considered important identify its origin. It hypothesized that formed at elevated temperatures cooking, which indicated earlier studies rats fed...
The Swedish Governmental Commission on Environment and Health (SOU 1996) the Committee Environmental Objectives 2000) proposed, among other things, targets for carcinogenic air pollutants in order to fulfill national objectives reduction of harmful emissions
Exposure to acrylamide (AA) has been monitored by mass spectrometric detection of the adduct, N-(2-carbamoylethyl)valine (CEV), N-termini hemoglobin (Hb), according N-alkyl Edman method. In these studies, a conspicuous background level, about 40 pmol/g globin, apparently same adduct was regularly observed in Hb from persons without known exposure AA. For testing hypothesis that this originates AA formed cooking, rats were fed fried animal standard diet for 1 or 2 months. These animals...
The acrylamide content of heated foodstuffs should be considered to the net result complex reactions leading formation and elimination/degradation this compound. present study, involving primarily homogenized potato in an oven, was designed characterize parameters that influence these reactions, including heating temperature, duration heating, pH, concentrations various components. Higher temperature (200 degrees C) combined with prolonged times produced reduced levels acrylamide, due...
Objectives This study assessed the health effects of occupational acrylamide exposure using hemoglobin (Hb) adducts as biomarkers internal dose. Methods Two hundred and ten tunnel workers exposed for about 2 months to a chemical-grouting agent containing N-methylolacrylamide underwent examination. Blood samples were drawn analysis Hb acrylamide. Fifty claiming recently developed or deteriorated symptoms peripheral nervous system (PNS) referred neurophysiological Workers with Hb-adduct levels...
Acrylamide is a common dietary exposure that crosses the human placenta. It classified as probable carcinogen, and developmental toxicity has been observed in rodents.We examined associations between prenatal to acrylamide birth outcomes prospective European mother-child study.Hemoglobin (Hb) adducts of its metabolite glycidamide were measured cord blood (reflecting cumulated last months pregnancy) from 1,101 singleton pregnant women recruited Denmark, England, Greece, Norway, Spain during...
Determination of adducts to hemoglobin (Hb) is a useful approach for monitoring tissue doses ultimate carcinogens. This provides basis both risk estimation and the identification priori unknown environmental paper describes application new method analyses Hb cigarette smokers non-smokers. The results demonstrate raised level hydroxyethylation N-terminal valine that quantitatively compatible with ethene in smoke being source. magnitude ethylene oxide originating from inhaled suggests this...
A method that can be used for the monitoring of exposure to alkylating agents in environment is presented. It based on quantification alkylated N‐terminal valines hemoglobin, using a modified Edman degradation procedure. The detection limit (GC/electron capture detector or GC/MS) increased by two magnitudes ten when pentafluorophenyl isothiocyanate instead phenyl derivatization step. As little as one nmole N‐(—2 hydroxyethyl)valine per gram hemoglobin detected under practical conditions.
Background: In April 2002, the Swedish National Food Administration and a scientific group at University of Stockholm jointly announced that they had shown acrylamide to be formed during preparation food found it occur in many foodstuffs. These new findings were clearly concern types industrial processing as well home cooking. The Federation (Li) initiated financed formation an expert committee look into chemical mechanisms. present review is final report committee. Design: study identified,...
Acrylamide has shown developmental and reproductive toxicity in animals, as well neurotoxic effects humans with occupational exposures. Because it is widespread food can pass through the human placenta, concerns have been raised about potential of dietary exposures humans.We assessed associations prenatal exposure to acrylamide small for gestational age (SGA) birth weight.This study included 50,651 women Norwegian Mother Child Cohort Study (MoBa). assessment was based on intake estimates...
The knowledge about fetal exposure to acrylamide/glycidamide from the maternal through food is limited. Acrylamide, glycidamide, and ethylene oxide are electrophiles form adducts with hemoglobin (Hb), which could be used for in vivo dose measurement. In this study, a method analysis of Hb by liquid chromatography–mass spectrometry, adduct FIRE procedure, was applied measurements these compounds blood samples (n = 87) umbilical cord 219). levels three compounds, acrylamide, oxide, were...
Diesel fuels, classified as environmentally friendly, have been available on the Swedish market since 1991. The diesel fuel classification is based upon specification of selected composition and physical properties to reduce potential environmental health effects from direct human exposure exhaust. objective present investigation was compare most stringent, (MK1) reference used in "European Program Emissions, Fuels Engine Technologies" (EPEFE) program. study compares measurements regulated...
Journal Article Monitoring human exposure to ethylene oxide by the determination of haemoglobin adducts using gas chromatography—mass spectrometry Get access P.B. Farmer, Farmer 3MRC Toxicology Unit, MRC Laboratories, Woodmansterne RoadCarshalton, Surrey, UK Search for other works this author on: Oxford Academic PubMed Google Scholar E. Bailey, Bailey S.M. Gorf, Gorf M. Törnqvist, Törnqvist 1Department Radiobiology, University StockholmS-106 91, Stockholm, Sweden S. Osterman-Golkar,...