The clinical spectrum of respiratory syncytial virus (RSV) bronchiolitis in previously healthy infants is extremely variable. Thus, it likely that factors such as genetic heterogeneity contribute to disease severity. Toll-like receptor 4 (TLR4) and CD14 are part a complex involved the innate immune response RSV.The association TLR4 mutations (Asp299Gly Thr399Ile) CD14/-159 polymorphism were analyzed 99 hospitalized with severe RSV (group I). Eighty-two ambulatory mild II) 90 adults III)...

Thirty-two infants, aged 1 to 12 months, hospitalized with acute wheezing, were studied. They randomly divided into four treatment groups of eight patients each. The treatments intramuscular dexamethasone or placebo (double-blind), and salbutamol (oral inhaled), none (open), in all possible combinations. study was carried out as a randomized block design blocks infants each, matched by age clinical score. Average daily improvements, reflected changes the score length hospital stay,...

Abstract Ventricular function was evaluated using radionuclide ventriculography in 27 children with oropharyngeal obstruction and clinical features of obstructive sleep apnea. Their mean age 3.5 years (9 months to 7.5 years). Conventional assessment did not detect cardiac involvement 25 children; however, reduced right ventricular ejection fraction (less than 35%) found 10 (37%) patients (mean: 19.5 ± 2.3% SE, range: 8–28%). In 18 wall motion abnormality detected. 11 whom performed before...

To evaluate neurocognitive functions of children with obstructive sleep apnea syndrome (OSAS), before and after adenotonsillectomy, compared healthy controls. Prospective study. Thirty-nine OSAS aged 5 to 9 years (mean age, 6.8 ± 0.2 years) 20 7.4 1.4 who served as controls, underwent a battery tests containing process-oriented intelligence scales. Twenty-seven in the group follow-up testing 6 10 months adenotonsillectomy. Fourteen control were also reevaluated first evaluation. Children had...

To evaluate whether socioeconomic status (SES) has a role in obstructive sleep apnea syndrome (OSAS) patients' decision to accept continuous positive airway pressure (CPAP) treatment.Cross-sectional study; patients were recruited between March 2007 and December 2007.University-affiliated laboratory.162 consecutive newly diagnosed (polysomnographically) adult OSAS who required CPAP underwent attendant titration 2-week adaptation period.40% (n = 65) of therapy accepted this treatment. Patients...

Health care use, a reliable measure of morbidity, is noticeably higher 1 yr before obstructive sleep apnea syndrome (OSAS) diagnosis in preschool children. It not clear at what age OSAS-related morbidity becomes expressed.To explore and health use among children with OSAS starting from first year life.Case-control study, the life to date diagnosis, 156 patients (age range, 3-5 yr) their pair-matched healthy control subjects, by age, sex, primary physician, geographic location.Patients...

To validate a contact-free system designed to achieve maximal comfort during long-term sleep monitoring, together with high monitoring accuracy.We used (EarlySense, Ltd., Israel), comprising an under-the-mattress piezoelectric sensor and smartphone application, collect vital signs analyze sleep. Heart rate (HR), respiratory (RR), body movement, calculated sleep-related parameters from the EarlySense (ES) were compared data simultaneously generated by gold standard, polysomnography (PSG)....

BackgroundAirways of Cystic Fibrosis (CF) patients are Nitric Oxide (NO) deficient which may contribute to impaired lung function and infection clearance. Mycobacterium abscessus (M. abscessus) prevalence is increasing in CF associated with increased morbidity mortality. Here, we assess the safety efficacy intermittent inhaled NO (iNO) as adjuvant therapy refractory M. infection.MethodsA prospective, open-label pilot study iNO (160 ppm) administered five times/day during hospitalization (14...

To investigate health care utilization of children with obstructive sleep apnea syndrome (OSAS) 1 year after adenotonsillectomy (T&A).A longitudinal, case-controlled, prospective study was conducted at Clalit Health Care Services (CHS), a maintenance organization in the southern region Israel. We defined 3 groups children: 1) who had OSAS and were treated T&A (n = 130); 2) did not undergo surgery 90); 3) control subjects matched by age, sex, area residency 520) randomly selected from CHS...

Objective. Little is known about the effects of obstructive sleep apnea syndrome (OSAS) on utilization health care services in children. The present study compares medical service by children with OSAS that healthy Methods. A cross-sectional 287 consecutively recruited (1–18 years) and no concomitant diseases a control group matched age, gender, geographic location was conducted at Clalit Health Care Services clinic southern region Israel. Children underwent nocturnal polysomnography (PSG)...

Abstract The aim of this study was to evaluate the efficacy (expressed as effect on lung function) and tolerability Symbicort® (budesonide/formoterol in a single inhaler) children with asthma. This double‐blind, double‐dummy, randomized, parallel‐group, multicenter trial. After 2–4‐week run‐in period, 286 asthmatic (177 boys, 109 girls; mean age, 11 years; forced expiratory volume 1 sec (FEV ), 75% predicted normal), previously treated inhaled corticosteroids (average dose 548 μg/day), were...

We aimed to examine the hypothesis that behavioral and neurocognitive functions of preschool children with Obstructive Sleep Apnea Syndrome (OSAS) are impaired compared healthy children, improve after adenotonsillectomy (TA).A comprehensive assessment battery was used assess cognitive functions, quality life in OSAS matched controls.45 (mean age 45.5 ± 9 months, 73% boys, BMI 15.7 2) were 26 48.6 8 46% 16.4 2). Mean AHI group 13.2 10.7 (ranging from 1.2 57). Significantly planning fluency...

Sleep-disordered breathing is common among patients with stroke resulting in 4- to 6-fold higher prevalence of obstructive sleep apnea (OSA). We prospectively evaluated clinical characteristics and laboratory markers inflammation coagulability associated OSA severity during the acute post period.Consecutive admitted department Neurology after an ischemic were first 48 hours symptom onset using Watch peripheral arterial tonometry, a wrist-worn ambulatory study device that utilizes tonometry....

<h3>Objective</h3> To characterize the sleep pattern of children with atopic dermatitis in clinical remission. <h3>Methods</h3> Fourteen dermatitis, a mean±SD age 6±2 years, were recruited consecutively from pediatric dermatology clinic. No participant had any other medical or psychiatric illness. The control group (n=9, mean 7±1.8 years) was composed mild "benign" snoring and no evidence respiratory disturbance during sleep. All participating evaluated by formal all-night polysomnography,...

To characterize the function and quality of sleep in patients with irritable bowel syndrome (IBS).A prospective study a historic comparison group.A regional hospital that also serves as tertiary referral center.Eighteen IBS group 20 matched adults mild benign snoring.A polysomnography wrist actigraphy study.All subjects underwent studies completed self-report questionnaires (IBS severity, psychosocial variables, function, Epworth Sleepiness Scale). Fourteen 11 actigraphy.The had more than...

Breath sounds were recorded in normal and asthmatic children over the chest trachea. The power spectra of analyzed for peaks high amplitude frequency as indications wheezing. percent inspiration expiration spent wheezing was used an indication severity bronchial obstruction. Wheezing found to be strongly dependent upon air flow, generally followed changes pulmonary function indicated by forced expiratory volume at 1 s (FEV1). trachea a better location analyzing wheezes than lung.