A5001357752- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Blood groups and transfusion
- Genetics, Bioinformatics, and Biomedical Research
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Single-cell and spatial transcriptomics
- Marine animal studies overview
- HIV Research and Treatment
- Chromosomal and Genetic Variations
- Immune Response and Inflammation
- Voice and Speech Disorders
- CAR-T cell therapy research
- Identification and Quantification in Food
- Herpesvirus Infections and Treatments
- Glycosylation and Glycoproteins Research
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
Université de Montpellier
2000-2025
Institut de Génétique Humaine
2000-2025
Centre National de la Recherche Scientifique
2000-2025
Institut de Génétique Moléculaire de Montpellier
2000-2022
Laboratoire d'Informatique Gaspard-Monge
2014-2021
Immungenetics (Germany)
2009
The Nature Conservancy
2009
IMGT®, the international ImMunoGeneTics information system®(http://www.imgt.org) is global reference in immunogenetics and immunoinformatics. By its creation 1989 by Marie-Paule Lefranc (Université de Montpellier CNRS), IMGT® marked advent of immunoinformatics, which emerged at interface between bioinformatics. specialized immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH) proteins IgSF MhSF superfamilies. built on IMGT-ONTOLOGY axioms concepts, bridged...
IMGT/LIGM-DB is the IMGT comprehensive database of immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences from human other vertebrate species. It was created in 1989 by LIGM, Montpellier, France oldest largest IMGT. includes all germline (non-rearranged) rearranged IG TR genomic DNA (gDNA) complementary (cDNA) published generalist databases. allows searches Web interface according to biological immunogenetic criteria through five distinct modules depending on user interest. For a...
Abstract IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org/, is at forefront of immunogenetics and immunoinformatics fields with more than 30 years experience. IMGT® makes available databases tools to scientific community pertaining adaptive immune response, based on IMGT-ONTOLOGY. We focus recent features databases, tools, reference directories web resources, within three main axes research development. Axis I consists in understanding by deciphering...
‘Human T Cell Receptor Beta Variable (TRBV) Genes’, the seventh report of ‘IMGT Locus on Focus‘ section, comprises four tables: (1) ‘Number human germline TRBV genes at 7q35 and potential repertoire’; (2) 7q35’; (3) orphons chromosome 9 (9p21)’, (4) allele table’. These tables are available IMGT Marie-Paule page from <i>IMGT</i>, international ImMunoGeneTics database <i>(http://imgt.cines.fr: 8104)</i> created by Lefranc, Université Montpellier II, CNRS, France.
Domestic ferrets (Mustela putorius furo) are important for modeling human respiratory diseases. However, ferret B and T cell receptors have not been completely identified or annotated, limiting immune repertoire studies. Here we performed long read transcriptome sequencing of splenocyte lymph node samples to obtain over 120,000 high-quality full-length immunoglobin (Ig) receptor (TCR) transcripts. We constructed a complete reference set the constant regions Ig TCR isotypes chain types. also...
ABSTRACT Domestic ferrets ( Mustela putorius furo ) are important for modeling human respiratory diseases. However, ferret B and T cell receptors have not been completely identified or annotated, limiting immune repertoire studies. Here, we performed long-read transcriptome sequencing of splenocyte lymph node samples to obtain over 120,000 high-quality full-length immunoglobin (Ig) receptor (TCR) transcripts. We constructed a complete reference set the constant regions Ig TCR isotypes chain...
The domestic cat (Felis catus) is an important companion animal and used as a large model for human disease. However, the comprehensive study of adaptive immunity in this species hampered by lack data on lymphocyte antigen receptor genes usage. objectives were to annotate feline T cell (TR) loci characterize expressed repertoire lymphoid organs normal cats using high-throughput sequencing.The Felis catus TRG locus contains 30 genes: 12 TRGV, TRGJ 6 TRGC, TRB 48 33 TRBV, 2 TRBD, 11 TRBJ,...
IMGT®, the international ImMunoGeneTics information system® is global reference in immunogenetics and immunoinformatics. By its creation 1989 by Marie-Paule Lefranc (Université de Montpellier CNRS), IMGT® marked advent of immunoinformatics, which emerged at interface between bioinformatics. specialized immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), proteins IgSF MhSF superfamilies. are divided into two groups, αβ γδ TR, express distinct TR...
'Nomenclature and overview of the mouse (Mus musculus Mus sp.) immunoglobulin kappa (IGK) Genes', 19th report 'IMGT Locus in Focus' section, provides first complete list all (M. musculus) IGK genes. The locus spans 3,200 kb. total number genes per haploid genome is 164 (174 if orphons are included). functional genomic repertoire comprises 93 IGKV belonging to 18 subgroups, 5 IGKJ 1 IGKC gene. IMGT gene names definitions on chromosome 6 provided with functionality alleles, according concepts...
‘Protein Displays of the Human T Cell Receptor Alpha, Beta, Gamma and Delta Variable Joining Regions’, 13th report ‘IMGT Locus in Focus’ section, comprises 8 figures: (1) display human TRA V-REGIONs’; (2) TRB (3) TRG (4) TRD (5) J-REGIONs’; (6) J- REGIONs’; (7) (8) J-REGIONs’, 4 tables entitled: ‘FR-IMGT CDR-IMGT length TRAV genes’; TRBV TRGV TRDV genes’. These figures are available at IMGT Marie-Paule page from IMGT, international ImMunoGeneTics database (http:// imgt.cines.fr:8104) created...
‘Human T cell Receptor Beta Diversity (TRBD) and Joining (TRBJ) Genes’, the 10th report of ‘IMGT Locus in Focus’ section, comprises 6 tables: (1) germline TRBD genes’; (2) allele table’; (3) ‘Nucleotide protein displays human alleles (overview)’; (4) TRBJ (5) table’, (6) (overview)’. These tables are available on IMGT Marie-Paule page from <i>IMGT</i>, international ImMunoGeneTics database <i>(http://imgt.cines.fr:8104) </i>created 1989 by Lefranc, Université...
The adaptive immune system, along with the innate are two main biological processes that protect an organism from pathogens. system is characterized by specificity and extreme diversity of its antigen receptors. These receptors immunoglobulins (IG) or antibodies B cells T cell (TR) cells. IG proteins have a dual role in immunity: they recognize antigens trigger elimination mechanisms, to rid body foreign synthesis immunoglobulin heavy light chains requires gene rearrangements at DNA level...
The adaptive immune response provides the vertebrate system with ability to recognize and remember specific pathogens generate immunity, mount stronger attacks each time pathogen is encountered. T cell receptors are antigen of expressed by cells, which specifically processed antigens, presented as peptides highly polymorphic major histocompatibility (MH) proteins. (TR) divided into two groups, αβ γδ, express distinct TR containing either α β, or γ δ chains, respectively. TRα locus (TRA) TRδ...
Through the analysis of immunoglobulin genes at IGH, IGK, and IGL loci from four
Abstract The variable domains (V-DOMAIN) of the antigen receptors, immunoglobulins (IG) or antibodies and T cell receptors (TR), which specifically recognize antigens show a huge diversity in their sequences. This results from complex mechanisms involved synthesis these at DNA level (rearrangements (V), (D), joining (J) genes; N-diversity; and, for IG, somatic hypermutations). recognition V, D, J as “genes” entry databases mark creation IMGT by Marie-Paule Lefranc, origin immunoinformatics...
The bottlenose dolphin (Tursiops truncatus) belongs to the Cetartiodactyla and, similarly other cetaceans, represents most successful mammalian colonization of aquatic environment. Here we report a genomic, evolutionary, and expression study T. truncatus T cell receptor beta (TRB) genes. Although organization TRB locus is similar that artiodactyl species, with three in tandem D-J-C clusters located at its 3′ end, uniqueness given by reduction total length due essentially absence duplications...
Abstract Through the analysis of immunoglobulin genes at IGH, IGK, and IGL loci from four Gorilla gorilla genome assemblies, IMGT ® provides an in-depth overview these their individual variations in a species closely related to humans. The similarity between human IG gene organization allowed assignment names based on counterparts. This study revealed significant findings, including variability IGH locus, presence known new copy number (CNVs), accurate estimation IGHG genes. IGK locus...
Abstract The cDNA sequences of immunoglobulins (IG) and T cell receptors (TR) represent more than one half the in IMGT^®^ nucleotide database IMGT/LIGM-DB^1^ 75% them are from human mouse. A few germline but great majority results a V-D-J or V-J gene rearrangement, spliced to C gene. IG TR genes have been studied extensively ("http://www.imgt.org":http://www.imgt.org) ^2^, which allowed set up their nomenclature corresponding reference sequences. These standardized directory sets (one for...
Abstract The immunoglobulin (IG) and T cell receptor (TR) major loci span about 6 Megabases (Mb) of the human genome on chromosomes 2, 7, 14 22, 9 Mb in mouse 6, 12, 13, 16. There are seven loci: three IG (IGH, IGK, IGL) four TR (TRA, TRB, TRG, TRD), with a distinct repartition variable (V), diversity (D), joining (J) constant (C) genes. comprises total number 608-665 genes (371-422 237-243 TR), depending haplotypes, per haploid ^1, 2^ which 531-588 located (distributed 369-418 V, 32 D,...
Abstract IMGT/LIGM-DB^1^ is the first and largest IMGT^®^ database^2^ in which are managed, analysed annotated more than 136,000 immunoglobulin (IG) T cell receptor (TR) nucleotide sequences from human 235 other vertebrate species (April 2009). The expert annotation of these added standardized knowledge based on IMGT-ONTOLOGY, ontology developed field immunogenetics immunoinformatics.^3^ immunogenetic requires important expertise, owing to unusual structure (non-classical exon/intron...
IMGT/LIGM-DB^1^ is the first and largest IMGT^®^ database^2^ in which are managed, analysed annotated more than 136,000 immunoglobulin (IG) T cell receptor (TR) nucleotide sequences from human 235 other vertebrate species (April 2009). The expert annotation of these added standardized knowledge based on IMGT-ONTOLOGY, ontology developed field immunogenetics immunoinformatics.^3^ immunogenetic requires important expertise, owing to unusual structure (non-classical exon/intron structure) IG TR...
The immunoglobulin (IG) and T cell receptor (TR) major loci span about 6 Megabases (Mb) of the human genome on chromosomes 2, 7, 14 22, 9 Mb in mouse 6, 12, 13, 16. There are seven loci: three IG (IGH, IGK, IGL) four TR (TRA, TRB, TRG, TRD), with a distinct repartition variable (V), diversity (D), joining (J) constant (C) genes. comprises total number 608-665 genes (371-422 237-243 TR), depending haplotypes, per haploid ^1, 2^ which 531-588 located (distributed 369-418 V, 32 D, 105-109 J...
The cDNA sequences of immunoglobulins (IG) and T cell receptors (TR) represent more than one half the in IMGT^®^ nucleotide database IMGT/LIGM-DB^1^ 75% them are from human mouse. A few germline but great majority results a V-D-J or V-J gene rearrangement, spliced to C gene. IG TR genes have been studied extensively ("http://www.imgt.org":http://www.imgt.org) ^2^, which allowed set up their nomenclature corresponding reference sequences. These standardized directory sets (one for each group...