A practical and efficient Rh(<sc>iii</sc>)-catalyzed oxidative C–H annulation using molecular oxygen as the sole oxidant has been developed for facile synthesis of a broad range indoles from simple anilines alkynes.

The catalytic and enantioselective construction of quaternary (all-carbon substituents) stereocenters poses a formidable challenge in organic synthesis due to the hindrance caused by steric factors. One conceptually viable potentially versatile approach is coupling C–C bond through an outer-sphere mechanism, accompanied realization enantiocontrol cooperative catalysis; however, examples such processes are yet be identified. Herein, we present method for creating different compounds with...

Abstract A fundamentally novel approach to bioactive quinolizinones is based on the palladium‐catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I 2 ], which features a very large bite angle, has been found facilitate rapid carbonylation azaarene‐substituted allylamines into in good excellent yields. This transformation represents first dearomative and proposed proceed by CN bond activation, dearomatization, CO insertion, Heck reaction.

Under mild conditions, the oxidative functionalization of C-H bonds adjacent to an amide nitrogen atom was achieved. tert-Butylperoxyamido acetal obtained in high yields and could be further converted into α-substituted amides by treatment with Grignard reagents.

Abstract Transition metal-catalyzed enantioconvergent cross-coupling of an alkyl precursor presents a promising method for producing enantioenriched C(sp 3 ) molecules. Because alcohol is ubiquitous and abundant family feedstock in nature, the direct reductive coupling aryl halide enables efficient access to valuable compounds. Although several strategies have been developed overcome high bond dissociation energy C − O bond, asymmetric pattern remains unknown. In this report, we describe...

An efficient copper-catalyzed approach to benzo[b]thiophene and benzothiazole derivatives using thiocarboxylic acids as a sulfur source has been developed. In the presence of CuI 1,10-phen, n-Pr3N base, (2-iodobenzyl)triphenylphosphonium bromide (2-iodophenylimino)triphenylphosphorane reacted smoothly with give in good yields via sequential Ullmann-type C-S bond coupling Wittig condensation.

A new strategy was developed for activation of C–N bond via formation an amine–I2 charge-transfer complex, which facilitates the inert oxidative addition with Ni(0). This has been successfully applied in Ni-catalyzed carbonylation benzylamines direct insertion CO into bond, provided a straightforward and rapid approach to arylacetamides presence catalytic amounts I2 Ni catalyst. Mechanistic studies suggested that benzyl radical generated involved present reaction.

Pd(Xantphos)Cl₂ has been identified as an efficient catalyst for the direct carbonylation of allylamines <italic>via</italic> C–N bond activation.

Abstract A new protocol for the synthesis of imides has been developed. In presence copper catalyst, N ‐benzylamides were oxidized to corresponding by TBHP/TEMPO system in moderate good yields.

Abstract An efficient approach to imides has been developed. With tert ‐butyl hydroperoxide (TBHP) as the oxidant, CuBr (20 mol‐%) catalyst, and PhI(OAc) 2 (50 additive, aldehydes or alcohols reacted with amine hydrochloride salts provide in moderate good yields. A possible reaction pathway for formation of products is also discussed this paper.

A nickel-catalyzed alkylarylation of active alkenes with tertiary benzylamines was achieved by charge-transfer-complex promoted C-N bond activation. The reaction proceeded through initial Ni-catalyzed activation, followed sequential radical addition, redox and proton abstraction cleaved amine moiety in the absence oxidant, provides an efficient method to prepare various alkyl-substituted oxindoles dihydroquinolinones good yields.

Abstract A fundamentally novel approach to bioactive quinolizinones is based on the palladium‐catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I 2 ], which features a very large bite angle, has been found facilitate rapid carbonylation azaarene‐substituted allylamines into in good excellent yields. This transformation represents first dearomative and proposed proceed by CN bond activation, dearomatization, CO insertion, Heck reaction.

Dehydrogenative cyclization of<italic>N</italic>-acyl dipeptide esters was developed and imidazolidin-4-ones were obtained in moderate to good yields by using TBHP as oxidant KI catalyst under mild conditions.

Abstract A novel and efficient approach to sulfonamides has been developed. Using TBHP as the oxidant NH 4 I (20 mol%) catalyst, arylsulfonyl hydrazides reacted with amines provide in moderate good yields. Possible reaction pathway for formation of products was also discussed this paper.

We have developed the first example of nickel-catalyzed Heck-type benzylation aryl olefins with various benzylamines as benzyl electrophiles, and benzylic C-N bond cleavage was efficiently promoted by amine-I2 charge transfer complex (CT complex). The combination low-cost NiCl2 I2 has been found to facilitate Heck reaction tertiary alkenes into benzyl-substituted in good excellent yields. This unconventional is proposed go through initially formation a radical via oxidative addition Ni(0),...

A convenient method to prepare α‐alkoxy ketones has been developed by oxidative coupling of aryl methyl and alcohols. With aqueous tert ‐butyl hydroperoxide (6.0 equiv.) as the oxidant, tetrabutylammonium iodide (20 mol‐%) catalyst, TsNHNH 2 (1.0 additive, underwent direct alkoxylation give α‐methoxy or α‐ethoxy in moderate good yields.

Abstract The direct oxidative cross‐coupling between N ‐acyl‐2‐aminoacetophenones and toluene derivatives was developed with a new C–C bond being formed under metal‐free environmentally friendly conditions excellent atom economy. A possible reaction pathway for the formation of products is also discussed in this paper. magnified image

Abstract An efficient metal‐free approach to the synthesis of 2‐aminobenzofuran‐3(2 H )‐ones has been developed. Using TBHP as an oxidant and I 2 (or TBAI) catalyst, 2‐acylphenols were treated with secondary amines provide )‐one derivatives in moderate good yields. A possible reaction pathway for formation 2‐dimorpholinobenzofuran‐3(2 is also discussed herein.

The electrochemical dehydrogenative cyclization of N ‐benzylamides was investigated with a Pt plate anode and graphite rod cathode in an undivided cell at room temperature. oxidative degradation the products suppressed successfully 4 H ‐1,3‐benzoxazines were obtained regardless substituents benzylic position. This method also allowed for preparation ‐1,3‐benzothiazines.

Bis(tributyltin)-initiated atom transfer cyclization reactions of 3-butenyl iodoalkanoates in the presence BF3.OEt2 as catalyst afforded 6-exo products a mixture 3,4-cis- and trans-substituted tetrahydro-2H-pyran-2-ones 53-71% yield with major isomers being cis ones. Ab initio calculations at B3LYP/6-31G level on transition states radical cyclized revealed that are kinetically controlled for boat conformations. Moreover, cis-oriented lower energy than corresponding trans-oriented ones, which...

A radical trifluoromethylation reaction of tertiary enamides was investigated and trifluoromethyl-containing isoindolinones were prepared under mild conditions. Using TMSCF3 as a source, PhI(OAc)2 an oxidant KHF2 additive, converted to via cascade addition cyclization process in moderate good yields.

Abstract The regioselectivity of radical addition and cyclization reaction tertiary enamides between 5‐membered benzoyl group 5/6/7‐membered benzyl ring closure was investigated, trifluoroethyl ‐containing N ‐Acyl isoindolines, ‐acyl tetrahydro‐isoquinolines, ‐benzoyl tetrahydro‐1 H ‐benzo[c]azepine were obtained in moderate to good yields with high atom economy. Possible pathway for the formation products also discussed this paper. magnified image