A5043588006- Pesticide Exposure and Toxicity
- International Science and Diplomacy
- Agriculture and Biological Studies
- Rabbits: Nutrition, Reproduction, Health
- Neuroscience and Neuropharmacology Research
- Animal Nutrition and Physiology
- Food Industry and Aquatic Biology
- Ukraine: War, Education, Health
- Cholinesterase and Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Biochemical effects in animals
- Molecular Sensors and Ion Detection
- Bacterial biofilms and quorum sensing
- Effects of Environmental Stressors on Livestock
- Clostridium difficile and Clostridium perfringens research
- Stress Responses and Cortisol
- Trace Elements in Health
- Oral microbiology and periodontitis research
- Selenium in Biological Systems
- Advanced Nanomaterials in Catalysis
- Hair Growth and Disorders
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Peptides and Activities
- Powdery Mildew Fungal Diseases
- Skin and Cellular Biology Research
Institute of Animal Biology NAAS
2011-2024
National Academy of Agrarian Sciences of Ukraine
2022-2024
Inserm
2006
Institut de Neurobiologie de la Méditerranée
2006
The extracellular signal-regulated kinases (ERK) signalling cascade is a key pathway that mediates the NMDA receptor (NMDAR)-dependent neuronal plasticity and survival. However, it not clear yet how NMDARs regulate ERK activity. Stimulation of induces complex modification includes both activation inactivation depends on particular experimental conditions. Here we show there exists differential restriction in regulation activity pool NMDAR was activated. synaptic activates whereas...
KCC2 is a neuron-specific potassium-chloride co-transporter controlling intracellular chloride homeostasis in mature and developing neurons. It implicated the regulation of neuronal migration, dendrites outgrowth formation excitatory inhibitory synaptic connections. The function suppressed under several pathological conditions including trauma, different types epilepsies, axotomy motoneurons, inflammations ischaemic insults. However, it remains unclear how down-regulation contributes to...
Taurine is a non-protein amino acid that participates in processes related to the body’s response stressful situations. Most animals, including birds, can synthesize taurine but at stress conditions, requirement increases and synthesis does not always meet needs. Given potential benefits of taurine, our study was conducted determine efficacy on blood biochemistry laying hens subjected heat stress. White Leghorn 180 days old were divided into 3 groups 16 birds each. The 1st group control,...
Chlorpyrifos is one of the most common pesticides around world. This organophosphorus compound inhibits acetylcholinesterase activity. A toxicity chlorpyrifos not limited to inhibition cholinesterase activity, but may act through other mechanisms, including breaking antioxidant-prooxidant balance. The goal study was conduct a comparative analysis key indicators antioxidant defense system in different brain regions rats intoxicated with chlorpyrifos. Wistar male were injected...
The general characteristics of ionophore antibiotics and the mechanisms their antimicrobial action were analyzed. Two types are known: those that transport ions across membrane, form a channel in cell membrane through which pass. Ionophore used animal husbandry belong to former group (monensin, lasalocid, salinomycin, narasin). They synthesized by bacteria Streptomyces genus. Bacterial cells rumen fluid differ ionic composition, is regulated active ion transport. As result, cytoplasm...
A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound screened for its antimicrobial activity against some pathogenic bacteria fungi showed Staphylococcus Saccharomyces cerevisiae (the Minimum Inhibitory Concentration (MIC) 820 μM). studied in the rat adjuvant arthritis model (Freund’s Adjuvant) vivo. Parietal fecal microbial composition using 16S rRNA metagenome sequences checked. We...
Background. The environmental crisis has affected the annual ambient temperature increase, adversely affecting mammalian body. Due to their lack of sweat glands, Rabbits are more sensitive heat stress than other animals. effect elevated temperatures on rabbit body leads violations blood parameters, endocrine regulation, immune and reproductive function, which reduces productivity increases animal mortality. Particular attention is now paid study organic compounds trace elements,...
У роботі досліджували вплив тривалої дії низьких доз хлорпірифосу на поведінку самиць лабораторних щурів.Тваринам щоденно протягом місяця вводили хлорпірифос у дозах 5 та 10 мг/кг і вивчали його низку важливих поведінкових показників за допомогою тестів: водний лабіринт Морріса, відкрите поле темно-світла камера.Виявлено, що дозі погіршує коротко-та довготривалу просторову пам'ять, знижує загальну активність, спричиняє різкі коливання рівня тривожності (вона значно зростала початку введення...
Nowadays, the interest in studying impact of feed additives on organism piglets during critical periods weaning remains increasingly relevant. Feed containing blends essential oils with plant extracts, preparations dry yeast, organic acids, pro- and prebiotics are suggested to replace growth promoters antibiotics. This contributes increased productivity, survivability, immune response formation, ensuring normal intestine morphology piglets. Proper concentrations timing additive application...
Abstract Conflicts and natural disasters affect entire populations of the countries involved and, in addition to thousands lives destroyed, have a substantial negative impact on scientific advances these provide. The unprovoked invasion Ukraine by Russia, devastating earthquake Turkey Syria, ongoing conflicts Middle East are just few examples. Millions people been killed or displaced, their futures uncertain. These events resulted extensive infrastructure collapse, with loss electricity,...
Background: Tetrachloromethane (CCl4) is a highly toxic environmental pollutant that causes specific and serious damage to various organs of animals humans. The study its effect on physiological biochemical processes in the mammalian organism very important, despite severe restrictions use tetrachloromantane recent years. fact they can be used as model for many toxicological studies. Objective: experimental studies aimed at exploring ameliorative effects L-glutamic acid (LGlu) CCl4 toxicity...
The review presents literature data on the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) formation bacterial biofilms.The role biofilm structures as a factor virulence microorganisms is shown, and protective reactions macroorganism in infectious processes caused by bacteria -producers biofilms are characterized.The article also provides examples methods for studying strategies managing this process.The prospects further study complex interaction between pathogens which may help to...
The aim of the study was to measure certain biochemical parameters in bull blood serum and activity antioxidant protection enzymes under feeding 15-month-aged calves with Chromium (III) methionine chelate form.Four time periods 15 days each were applied.At 1 st (preparatory) period, animals received basic ration (BR), while at 2nd, 3rd 4th compounds (0.8 mg pure metal per day for animal), as a solution added morning watering.Blood obtained from jugular vein 2 hours after feeding, start 1st...
The goal of the study is to optimize mode disruption yeast Phaffia rhodozyma KNH 1 by a vibration-resonant low-frequency cavitator (VLC). destruction cell biomass culture P. strain was carried out in VLC with water cooling, capacity 800 W, and resonant frequencies vibrations 30 Hz, 35 37 37.8 39 50 presence nitrogen reaction medium. Our data suggest that yield processed treatment depends on age treatment. Thus, for six-day culture, we got highest its processing at Hz 75 min. from five-day...