A5068385071- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Genetic factors in colorectal cancer
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
University of North Carolina at Chapel Hill
2017-2019
Abstract Dysplasia is considered a key transition state between pre-cancer and cancer in gastric carcinogenesis. However, the cellular or phenotypic heterogeneity mechanisms of dysplasia progression have not been elucidated. We established metaplastic dysplastic organoid lines, derived from Mist1-Kras(G12D) mouse stomach corpus studied distinct behaviors characteristics organoids. also examined functional roles for Kras activation using Selumetinib, MEK inhibitor, which downstream mediator...
Cellular heterogeneity in cancer development is considered as a source of cell generation and drug resistance. However, cellular has not been fully eluciated during metaplasia progression to gastric pre-neoplasia neoplasia carcinogenesis. Recent investigations have suggested that Ras activation, rather than mutation, may promote the We recently established several vitro metaplastic/pre-neoplastic organoid lines; Meta3-metaplasia Meta4-pre-neoplasia, derived from mouse stomachs induced active...
Abstract Cellular heterogeneity in cancer development is considered as a source of cell generation and drug resistance. However, cellular has not been fully eluciated during metaplasia progression to gastric pre-neoplasia neoplasia carcinogenesis. Recent investigations have suggested that Ras activation, rather than mutation, may promote the We recently established several vitro metaplastic/pre-neoplastic organoid lines; Meta3-metaplasia Meta4-pre-neoplasia, derived from mouse stomachs...