Generation of deep-ultraviolet femtosecond pulses by four-wave mixing through filamentation in neon gas was demonstrated. Fundamental (omega) and second-harmonic (2omega) 25 fs Ti:sapphire amplifier output were focused into gas, 20 microJ with the center wavelength 260 nm produced a process, 2omega+2omega-omega?3omega an ~15 cm filament. Additionally, energy 2 at 200 generated, probably cascaded 3omega+2omega-omega?4omega. The compressed grating-based compressor characterized dispersion-free...

The streaming potentials of liquid beams aqueous NaCl, NaBr, and NaI solutions are measured using soft X-ray, He(I), laser multiphoton ionization photoelectron spectroscopy. Gaseous molecules ionized in the vicinity energy shifts as a function distance between point beam. change their polarity with concentration electrolytes, from which singular points eliminating determined. currents air also vanish at these concentrations. electron binding energies water I(-), Br(-), Cl(-) anions revisited...

We examined the inhibition by atrial natriuretic peptide (ANP) and brain (BNP) of endothelin-1 secretion stimulated angiotensin II (ANGII) thrombin using cultured human umbilical-vein endothelial cells. ANGII dose-dependently immunoreactive (ir) secretion. Human ANP(1-28) BNP-32 both inhibited such in a dose-dependent way. Inhibition this ANP BNP was paralleled an increase level cyclic guanosine 5'-monophosphate (GMP). The addition GMP analogue, 8-bromo GMP, reduced Rat ANP(5-25) weaker than...

The ultrafast S2 → S1 internal conversion of pyrazine through a conical intersection the potential energy surfaces was clearly observed by photoelectron imaging. 2D time-energy map angular anisotropy revealed clear signature (the color change green-orange-green in horizontal direction) at ∼0.9 eV. orange ∼20 fs and 0.9 eV found to correspond non-Koopmans ionization process from S2(π,π*) D0(n−1).

High-resolution soft X-ray photoelectron spectra of liquid water (H(2)O and D(2)O) were measured using a beam spectrometer. The 1a(1) (O1s) band the lowest valence 1b(1) had single peaks, which is not consistent with split 1b(1)→ emission if splitting assumed to originate from level shifts in two different hydrogen bonding structures. second 3a(1) exhibited flat top implying that bands exist underneath broad feature, similar case amorphous ice. energy between estimated be 1.38 eV (H(2)O)...

A nonadiabatic electronic transition through a conical intersection was studied by pump-probe photoelectron imaging spectroscopy with 22 fs time resolution in the benchmark polyatomic molecule of pyrazine and deuterated pyrazine. The lifetimes S(2) state were determined to be 22+/-3 global fitting time-energy maps kinetic energy (PKE) distributions. lifetime S(3) 40-43 fs. Two-dimensional distributions obtained for (t) PKE, individual PKE upon ionization from S(1) extracted. Quantum beat an...

Forty patients with solar urticaria, 16 male and 24 female, were examined personally during the past 25 years. The median age at onset of symptoms was 32 years, ranging from 13 to 76 Most commonly (45%) urticaria first appeared third decade. mean duration disease 3.6 years presentation. action spectrum found in visible light range (60%), ultraviolet (UV) A four, UVB UVA three, one a broad four patients. An inhibition detected 19 (68%), occurring longer wavelengths than 12 these cases....

We measured plasma concentrations of immunoreactive endothelin-1 (irET-1) in the prehypertensive and hypertensive phases spontaneously rats (SHR) malignant hypertension caused by deoxycorticosterone acetate (DOCA)-salt administration SHR. also this peptide another model hypertension, two-kidney, one clip (2K1C) renovascular chronically given caffeine. Plasma irET-1 young (6-week-old) mature (18-week-old) SHR did not differ from those age-matched Wistar-Kyoto (WKY) rats. Four weeks treatment...

Recent studies have shown that an elevated ambulatory or home blood pressure (BP) in the absence of office BP-a phenomenon called masked hypertension-is associated with poor cardiovascular prognosis. However, it remains to be elucidated how hypertension modifies target organ damage treated hypertensive patients.A total 332 outpatients chronically essential were enrolled present study. Patients classified into four groups according (<140/90 >or=140/90 mm Hg) and daytime (<135/85 >or=135/85 BP...

Ultrafast photodynamics of furan has been studied by time-resolved photoelectron imaging (TRPEI) spectroscopy with an unprecedented time resolution 22 fs. The simulation the time-dependent kinetic energy distribution (PKED) performed ab initio nonadiabatic dynamics “on fly” in frame density functional theory. Based on agreement between experimental and theoretical signal intensity as well PKED, precise scales ultrafast internal conversion from ${\rm S}_{\rm 2}$S2 over 1}$S1 to ground state...

We present time- and angle-resolved photoemission spectroscopy of trapped electrons near liquid surfaces. Photoemission from the ground state a hydrated electron at 260 nm is found to be isotropic, while anisotropic observed for excited states 1,4-diazabicyclo[2,2,2]octane ${\mathrm{I}}^{\ensuremath{-}}$ in aqueous solutions. Our results indicate that surface subsurface species create bulk side. No signature surface-bound has been observed.

The photoinduced ring-opening reaction of 1,3-cyclohexadiene (CHD) to produce 1,3,5-hexatriene (HT) plays an essential role in the photobiological synthesis vitamin D3 skin. This follows Woodward-Hoffmann rule, and C5-C6 bond rupture via electronically excited state occurs with conrotatory motion end CH2 groups. However, it is noted that photoexcited S1(π,π*) CHD not correlated ground HT, must proceed nonadiabatic transitions. In present study, we have clearly observed pathway doubly using...

Left ventricular (LV) hypertrophy and LV diastolic dysfunction, which are common cardiac changes in hypertensive patients, modified by several nonhemodynamic (eg, genetic, neurohumoral, metabolic) factors. However, the influence of serum lipids on these has not been sufficiently studied. Although low high-density lipoprotein (HDL) cholesterol is well known to be a major risk factor for coronary heart disease, it unclear whether HDL plays role disease.In 274 patients with treated essential...

Background:The attenuation of coronary flow reserve (CFR) and endothelium-mediated vasodilation the brachial artery (EMV-BA) have been frequently reported in hypertensive patients. The present study investigated link between CFR EMV-BA We hypothesized that changes serum asymmetric dimethylarginine (ADMA), an endogenous inhibitor nitric oxide synthase, concomitant insulin resistance may be underlying factors connecting two pathologic alterations.

Journal Article Pioglitazone Improves Left Ventricular Diastolic Function in Patients With Essential Hypertension Get access Takeshi Horio, Horio 1Division of and Nephrology, Department Medicine, National Cardiovascular Center, Suita, Japan Address correspondence reprint requests to Dr. Division 5-7-1, Fujishirodai, Osaka 565-8565, E-mail: thorio@ri.ncvc.go.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Masaaki Suzuki, Suzuki 3Department Gastroenterology...

The relationship of the rate epidermal proliferation to ultraviolet (UV)-induced cell death, namely sunburn (SC) formation, was investigated in vivo using guinea-pig model. number SCs correlated with (1) cellophane tape stripping which stimulates and (2) treatment antimitotic antimetabolic agents suppress rate. performed 14 h before UV irradiation significantly increased counted 24 after from a mean 17.4 62.6 per section, tritiated thymidine (TdR-3H)-labelling index (LI) 8.1 27.4%. SC counts...

Ultrafast internal conversion of benzene and toluene from the S(2) states was studied by time-resolved photoelectron imaging with a time resolution 22 fs. Time-energy maps intensity angular anisotropy were generated series images. The kinetic energy distribution exhibits rapid shift revival, which indicates nuclear motion on adiabatic surface, while ultrafast evolution revealed change in electronic character surface. From their decay profiles total intensity, constants 48 ± 4 62 fs...

A photoexcited molecule undergoes multiple deactivation and reaction processes simultaneously or sequentially, which have been observed by combinations of various experimental methods. However, a single method that enables complete observation the photo-induced dynamics would be great assistance for such studies. Here we report full cascaded electronic dephasing from S2(ππ*) in pyrazine (C4N2H4) time-resolved photoelectron imaging (TRPEI) using 9.3-eV vacuum ultraviolet pulses with sub-20 fs...

We present velocity-map imaging (VMI) of photoelectrons detached from anions using an optical parametric amplifier operating at a repetition rate as high 100 kHz. The light source generates femtosecond (fs) laser pulses tunable near-infrared to ultraviolet (310–2600 nm), which interact synchronously with mass-selected anion bunches. demonstrate this technique by measuring two-dimensional projections ejected silver trimer anions, Ag3−, across photon energy range 2.43 4.00 eV (509–310 average...

We examined the inhibitory effect of porcine C-type natriuretic peptide (CNP) on endothelin-1 secretion stimulated by thrombin and angiotensin II (Ang II) in cultured endothelial cells. The results were compared with effects atrial (ANP) brain (BNP) peptides. Thrombin Ang produced a concentration-dependent stimulation immunoreactive secretion, CNP-22 potently inhibited this manner. had stronger than either ANP(1-28) or BNP-26. In addition, CNP increased cellular level cyclic guanosine...

The purpose of this study was to investigate the possible role reactive oxygen species (ROS) generated by neutrophils in mediating acne inflammation. Antibiotics used for treatment significantly inhibited ROS neutrophils, when compared other antibiotics. Metronidazole, which is effective acne, markedly neutrophils. drug known have no significant effect on growth &lt;i&gt;Propionibacterium acnes. &lt;/i&gt;The proportion linoleic acid decreased comedones. Linoleic suppressed ability produce...

We investigated the antimicrobial effects of phototherapy and photochemotherapy in vivo vitro. First, Staphylococcus aureus samples were obtained using stamp agar medium from inflammatory lesions 29 adult patients with atopic dermatitis before after a single photochemotherapy. Therapy was oral PUVA (30 mg 8-methoxypsoralen, 8MOP plus 5J/cm2 UVA), topical (0.3% 200 mJ/cm2 UVA) or UVB (80 mJ/cm2) irradiation. The number S. on significantly reduced, even treatment all therapies. Reductions...