A5057105983- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Cholinesterase and Neurodegenerative Diseases
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Multicomponent Synthesis of Heterocycles
- Enzyme function and inhibition
- Synthesis of Tetrazole Derivatives
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Cancer therapeutics and mechanisms
- Analytical Chemistry and Chromatography
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Medicinal Plants and Neuroprotection
- Crystallography and molecular interactions
- Nanoparticle-Based Drug Delivery
- Organic Chemistry Cycloaddition Reactions
- Biochemical and Molecular Research
- Nonlinear Optical Materials Research
- Chemical Synthesis and Analysis
- Synthesis of Organic Compounds
Erzincan University
2020-2025
Erciyes University
2014-2019
In this study, we investigated the in vitro antiproliferative activities and performed computational studies of newly synthesized fluorinated isatin-hydrazones. The chemical structures compounds were confirmed by FT-IR, 1D NMR (1H- 13C APT), 2D (HETCOR HMBC), elemental analysis. All (1–15) tested human lung (A549) liver (HepG2) cancer cell lines for 72 h. screened against a healthy embryonic kidney line (HEK-293T) under same conditions to determine their toxic effects. According results...
Abstract In here, two new Schiff base molecules (3 and 4) were synthesized from the condensation reaction of 1‐amino‐5‐benzoyl‐4‐phenylpyrimidine‐2(1 H )‐one (1) 1‐amino‐5‐(4‐methylbenzoyl)‐4‐ p ‐tolylpyrimidin‐2(1 (2) with 4‐bromobenzaldehyde. These completely characterized by IR, NMR, HR‐MS. Moreover, molecule 4 was determined single crystal x‐ray diffraction (SC‐XRD) patterns. The crystallographic analysis revealed that crystallizes in monoclinic system, space group P2 1 /c. screened...
Three new thymol-based molecules were synthesized and evaluated as anticancer, antimicrobial antioxidant agents. Liver, colon, lung prostate cancer cell lines utilized in cytotoxicity tests. The results demonstrated that had a cytotoxic effect against the screened lines. One of (4a) was found to have higher efficacy towards colon line (DLD-1) with an IC50 value 12.39 µM other (4c) (PC3) 7.67 than positive control drug cisplatin. To assess activity (4a–c), Gram-positive bacteria,...
Abstract In this study, seven known compounds ( 5a–g ) were tested towards four human cancer cell lines including DLD‐1, HepG2, MDA‐MB‐231, and MCF‐7 for 48 h. addition, all also in a normal line (Wl‐38). The results showed that compound 5e particular had cytotoxic effects MCF‐7. molecular modeled structures of investigated the ground state optimized using density functional theory (DFT). chemical parameters determined by DFT calculations. HOMOs LUMOs revealed to provide reasonable...
Abstract In this study, a series of N ‐substituted‐( p ‐tolyl)pyridazin‐3(2 H )‐one derivatives were synthesized and evaluated for their AChE inhibitory activity. The chemical structures novel compounds 5 ( – m ) confirmed by 1 H‐NMR, 13 C‐NMR, IR HRMS analysis. order to eliminate the symptomatic effects Alzheimer's disease, proposed acetylcholinesterase inhibition activity study in accordance with cholinergic hypothesis. results revealed that inhibited enzymes significantly. K i values...
Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus phortress to 2-aryl and -heteroaryl benzoxazole derivatives (11 new 14 resynthesized). All synthesized compounds were studied for antitumor activity various cancer Materials & methods: Cytotoxicity, cell morphology, flow cytometry cell-cycle analyses of performed more active tested MCF-7 line. Conclusion: Methyl...
Abstract Heterocyclics containing pyridazinone and piperazine structures are potential anticancer agents in the treatment of cancer disease caused by increasing number abnormal cells disrupting body biochemistry. There is a need for design more biocompatible drugs with minimal side effects. For this purpose, series piperazinyl‐methyl‐3(2 H )pyridazinone based compounds were synthesized their activities studied vitro silico . The chemical all new 3 (a – k ) identified spectral analysis....