Owing to ever-increasing bacterial and fungal drug resistance, we attempted develop novel antitubercular antimicrobial agents. For this purpose, developed some new fluorine-substituted chalcone analogs (3, 4, 9-15, 20-23) using a structure-activity relationship approach. Target compounds were evaluated for their efficacy against Mycobacterium tuberculosis H37Rv activity five common pathogenic three strains. Three derivatives 9, 10) displayed significant with IC50 values of ≤16,760. Compounds...

Fused pyrimidines, especially pyrazolo[3,4-d]pyrimidines, are among the most preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of biological activity. In this study, new derivatives pyrazolo[3,4-d]pyrimidine were synthesized by alkylation N1 nitrogen atom. We 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2 from commercially available aminopyrazolopyrimidine 1 using N-iodosuccinimide an iodinating agent. The synthesis compound started with nucleophilic...

A straight forward one pot three component synthesis of seven novel derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2,3,4, 6, 8-hexahydro-1H-quinazolin-5-one by a cyclocondensation dimedone and substitutes aromatic aldehyde with thiourea in the presence PPh3 as catalyst to good yields. All structures products were confirmed 1H NMR 13C spectroscopy. The antibacterial activity some synthesized compounds was investigated against Staphylococcus aureus), epidermidis, Bacillus cereus, Esherichia coli,...

Abstract Fourteen novel Chalcone‐Cu complexes were effectively synthesized in this work. The newly assessed for their effects on human carbonic anhydrase isoenzymes I and II, acetylcholinesterase enzymes, antioxidant activity. intricate compounds exhibited Ki values ranging from 41.65–190.42 nM against hCA I, 15.79–259.07 14.36–175.73 AChE enzymes. These demonstrated potent inhibitory profiles the specified metabolic surpassing of acetazolamide (for II) tacrine AChE). properties using DPPH...

Pathological angiogenesis plays a critical role in tumorigenesis and tumor progression, anti-angiogenesis therapies have evinced promising antitumor effects solid tumors. Chalcone skeleton has been regarded as potential agent that also targets angiogenesis. In this study, we designed twenty-one non-fluoro-substituted chalcones (13–18, 24–27) saturated chalcone derivatives (19–23, 28–33) anti-angiogenic compounds. During the initial stage, these compounds were assessed for their anti-cancer...

A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel human tumor cell lines. Some the analogs (8, 9, 12, 45, 46 48) displayed powerful effects certain cells, but all them were devoid any cytotoxicity towards normal HEK 293. Acridine orange staining data supported that cytotoxic synthesized on cells are mediated through apoptosis. The compounds 12 manifested concentration-dependent in...

The experiment was carried out under three seasons with 15 genotypes at Agricultural Research Station, Kunaram, Telangana state, India during rabi season (December to April) 2014–15 (E1), kharif (July November) 2015 (E2) and 2015–16 (E3). objective of the study assess stability adaptability rice various maturity groups over seasons. GGE biplot tool these durations expressed a significant genotype, environment G×E interaction for yield days 50% flowering. Genotype effect responsible greatest...

Abstract Prostate cancer is the most frequently diagnosed tumor in men and second leading cause of cancer‐associated mortality developed countries. 3,5‐Diaryl substituted pyrazole derivatives ( 20 – 28 ) were prepared starting from related chalcones biologically evaluated for vitro growth inhibition activity against PC3 DU145 human prostate cell lines. Compounds 23 , 26 found to be more potent as compared other halogen‐substituted derivatives. Especially, 2‐bromo‐substituted derivative was...

Abstract We designed and synthesized a novel series of trimethoxy chalcones with CF 3 or F substituents at various positions ring B, characterized using IR, NMR spectral data, elemental analyses, based on the fact that methoxy fluoro‐substituted are included in literature as pharmacophore due to their anticancer activities. All compounds ( 12 ‐ 21 ) were tested for cytotoxicity against A549, HEPG2, MCF7, normal mouse fibroblasts (L929) XTT assay. The most active compound, 13 , was also shown...

In this study, 2′,4′,6′-Trimethoxyacetophenone was reacted with various fluorine-substituted benzaldehydes in the presence of an aqueous solution 50%-potassium hydroxide, and new chalcone derivatives structure 1,3-diaryl-2-propenone comprising both fluorine methoxy groups aromatic B ring were obtained high yields under mild conditions.In base-catalyzed Claisen-Schmidt condensations, MeOH is usually used as solvent.In condensation reactions performed mono-fluorine-substituted MeOH,...

The aim of this study was to investigate the effect different sowing dates on growth and yield potential pre released rice genotypes under irrigated conditions Northern Telangana zone. field experiments were carried out during two consecutive rabi seasons 2018-19 2019-20, clay soils agricultural research station, Kunaram, state, India. experiment laid in strip plot design with three replications. treatments comprised i.e. 20th November, 5th December horizontal factor four KNM 733, RNR 15048,...

Field experiments were conducted to evaluate the pre released rice genotypes under different sowing windows on clay soils of agricultural research station, Kunaram, Telangana state, India during two consecutive rainy seasons 2018 and 2019.The experiment was laid out in strip plot design with three replications. The treatments comprised dates i.e. 20thJune, 5thJuly 20thJuly horizontal factor four KNM 733, RNR 15048, 1638 118 vertical factor. pooled data results indicated that, among genotype...

Synthesis of (2S)-3-(2,4,5-trifluorophenyl)propane-1,2-diol by the Sharpless asymmetric epoxidation reaction has been achieved. 2,4,5-Trifluorobenzaldehyde with methyl 2-(triphenyl-λ5-phosphanylidene)acetate gave (E)-3-(2,4,5-trifluorophenyl)acrylate in 83% yield. The reduction ester group DibalH followed ((2R,3R)-3-(2,4,5-trifluorophenyl)oxiran-2-yl)methanol. Pd/C-catalyzed hydrogenation epoxy alcohol furnished >90% ee and 71%

Background: Sunnhemp is an important bast fibre crop suitable for diversified uses. Recently, its cultivation has started expanding considerably throughout the world particularly potential usage in sustainable farming and reducing use of synthetic fertilizers from agricultural system. Seed production are mutually exclusive sunnhemp because different photo-period requirements these purposes destructive extraction process. The major limitation popularization availability seed. In this context,...

Abstract Tetrasubstituted alkene derivatives are synthetically important compounds and one of the research areas in organic chemistry. Stereoselective synthesis all‐carbon tetrasubstituted alkenes is a challenging problem chemical because uncontrolled Z/E stereoselectivity. Here we described an unexpended stereocontrolled rearrangement for alkenes, each group different from other. The reaction ethyl 4‐hydroxy‐4‐(substituted phenyl)‐2‐butynoate with methanesulfonyl chloride triethylamine gave...

Recent predictions on climate change indicate that episodes of unseasonal rains, cold stress, and high temperatures are expected to impact rice production productivity. To obtain consistent yield across diverse environments, a variety should have adaptability stability fit into various growing seasons locations. In the present investigation, AMMI model was employed assess nine genotypes early maturity group two summer rainy seasons. Combined analysis variance expressed significant genotype,...