NFDI4DS | UHH-SEMS - Publication Details

Ester Gil Vázquez

ORCID: 0000-0002-5803-7290

Publications

Citations

Views

---

Saved

---

About

Contact & Profiles

A5019436047

Research Areas

Cancer Immunotherapy and Biomarkers
Immunotherapy and Immune Responses
Cancer Cells and Metastasis
Cancer-related gene regulation
Cell Adhesion Molecules Research
Colorectal and Anal Carcinomas
Immune Cell Function and Interaction
Peptidase Inhibition and Analysis
Cytokine Signaling Pathways and Interactions
Monoclonal and Polyclonal Antibodies Research
Galectins and Cancer Biology
Lymphoma Diagnosis and Treatment
Glycosylation and Glycoproteins Research
T-cell and B-cell Immunology
Antimicrobial Peptides and Activities
CAR-T cell therapy research
Wnt/β-catenin signaling in development and cancer
Colorectal Cancer Treatments and Studies
Pancreatic and Hepatic Oncology Research
Cancer Genomics and Diagnostics

University of Oxford
2022-2023

Centre for Human Genetics
2022

β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Abstract Intraepithelial lymphocytes (IEL) expressing γδ T-cell receptors (γδTCR) play key roles in elimination of colon cancer. However, the precise mechanisms by which progressing cancer cells evade immunosurveillance these innate T are unknown. Here, we investigated how loss Apc tumor suppressor gut tissue could enable nascent to escape cytotoxic γδIELs. In contrast with healthy intestinal or colonic tissue, found that γδIELs were largely absent from microenvironment both mouse and human...

10.1158/2326-6066.cir-22-0644 article EN cc-by Cancer Immunology Research 2023-06-13

Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression Btnl genes

10.1158/2326-6066.27026744.v1 preprint EN 2024-09-16

Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Deletion of Apc in organoids increases WNT target genes

10.1158/2326-6066.27026747.v1 preprint EN 2024-09-16

Figure S2 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Deletion of Apc in organoids increases WNT target genes

10.1158/2326-6066.27026747 preprint EN 2024-09-16

Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors

10.1158/2326-6066.27026741.v1 preprint EN 2024-09-16

Figure S3 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression Btnl genes

10.1158/2326-6066.27026744 preprint EN 2024-09-16

Figure S4 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors

10.1158/2326-6066.27026741 preprint EN 2024-09-16

Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells

10.1158/2326-6066.27026738.v1 preprint EN 2024-09-16

Figure S5 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells

10.1158/2326-6066.27026738 preprint EN 2024-09-16

Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.

10.1158/2326-6066.27026735 preprint EN 2024-09-16

Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells the tumor microenvironment

10.1158/2326-6066.27026732.v1 preprint EN 2024-09-16

Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Supplementary Figure Legends

10.1158/2326-6066.27026729 preprint EN 2024-09-16

Supplementary Figure Legends from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Supplementary Figure Legends

10.1158/2326-6066.27026729.v1 preprint EN 2024-09-16

Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Clinicopathological characteristics of colon cancer patient cohorts.

10.1158/2326-6066.27026726 preprint EN 2024-09-16

Table S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Clinicopathological characteristics of colon cancer patient cohorts.

10.1158/2326-6066.27026726.v1 preprint EN 2024-09-16

Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

WNT expression is independent of BTN3A1 and BTN2A1

10.1158/2326-6066.27026750.v1 preprint EN 2024-09-16

Figure S1 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

WNT expression is independent of BTN3A1 and BTN2A1

10.1158/2326-6066.27026750 preprint EN 2024-09-16

Figure S6 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.

10.1158/2326-6066.27026735.v1 preprint EN 2024-09-16

Figure S7 from β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells the tumor microenvironment

10.1158/2326-6066.27026732 preprint EN 2024-09-16

Figure S6 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.

10.1158/2326-6066.23657070 preprint EN cc-by 2023-07-10

Figure S4 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors

10.1158/2326-6066.23657076.v1 preprint EN cc-by 2023-07-10

Data from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

<div>AbstractIntraepithelial lymphocytes (IEL) expressing γδ T-cell receptors (γδTCR) play key roles in elimination of colon cancer. However, the precise mechanisms by which progressing cancer cells evade immunosurveillance these innate T are unknown. Here, we investigated how loss Apc tumor suppressor gut tissue could enable nascent to escape cytotoxic γδIELs. In contrast with healthy intestinal or colonic tissue, found that γδIELs were largely absent from...

10.1158/2326-6066.c.6735072.v1 preprint EN 2023-07-10

Figure S2 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Deletion of Apc in organoids increases WNT target genes

10.1158/2326-6066.23657082.v1 preprint EN cc-by 2023-07-10

Figure S5 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells

10.1158/2326-6066.23657073.v1 preprint EN cc-by 2023-07-10

Figure S2 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

OPENALEX - Publications

Toshiyasu Suzuki Anna Kilbey Nuria Casa-Rodríguez Amy Lawlor Αναστασία Γεωργακοπούλου and 27 more

Deletion of Apc in organoids increases WNT target genes

10.1158/2326-6066.23657082 preprint EN cc-by 2023-07-10

Coming Soon ...