A5073515855- Malaria Research and Control
- Mosquito-borne diseases and control
- Drug Transport and Resistance Mechanisms
- Iron Metabolism and Disorders
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Vector-borne infectious diseases
- Peptidase Inhibition and Analysis
- Aquaculture disease management and microbiota
- Antibiotic Resistance in Bacteria
- Hemoglobinopathies and Related Disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Insect Resistance and Genetics
Max Planck Institute for Infection Biology
2022-2024
Centre for Structural Systems Biology
2021-2024
European Molecular Biology Laboratory
2021-2022
McGill University
2012-2021
Robert Koch Institute
2017
ABSTRACT Host iron deficiency is protective against severe malaria as the human parasite Plasmodium falciparum depends on bioavailable from its host to proliferate. The essential pathways of acquisition, storage, export, and detoxification in differ those humans, orthologs mammalian transferrin receptor, ferritin, or ferroportin, a functional heme oxygenase are absent P. . Thus, proteins involved these processes may be excellent targets for therapeutic development, yet remain largely...
Abstract The Plasmodium falciparum M1 alanyl aminopeptidase and M17 leucyl aminopeptidase, Pf M1AAP M17LAP, are potential targets for novel anti-malarial drug development. Inhibitors of these aminopeptidases have been shown to kill malaria parasites in culture reduce parasite growth murine models. two enzymes may function the terminal stages haemoglobin digestion, providing free amino acids protein synthesis by rapidly growing intra-erythrocytic parasites. Here we performed a comparative...
The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which confers stability and shape to the cell, functions as scaffolding compartment during formation daughter cells plays an important role in motility invasion different life cycle stages these single-celled organisms. To explore IMC proteome malaria parasite Plasmodium falciparum we applied proximity-dependent biotin identification (BioID)-based proteomics approach, using established marker protein...
Abstract Mutations in the multidrug resistance transporter of P lasmodium falciparum Pf MDR 1 have been implicated to play a significant role emergence worldwide drug resistance, yet molecular and biochemical mechanisms this are not well understood. Although it is generally accepted that . partly associated with transport activity situated membrane digestive vacuole, direct estimates pump rate process natural environment intact host–parasite system never analysed. The fluorochrome Fluo‐4...
Host iron deficiency is protective against severe malaria as the human parasite Plasmodium falciparum depends on bioavailable from its host to proliferate. The essential pathways of acquisition, storage, export, and detoxification in differ those humans, orthologs mammalian transferrin receptor, ferritin, or ferroportin, a functional heme oxygenase are absent P. . Thus, proteins involved these processes may be excellent targets for therapeutic development, yet remain largely unknown. Here,...
SUMMARY The number of dengue epidemics in Brazil has increased dramatically the last 15 years. In this study, we analysed seasonal patterns incidence hospitalisations due to across different states and compared these with corresponding climatic patterns. We discovered that seasonality a clear zonal gradient, characterised by progression primary peaks from West East during first half year, which may be associated vapour pressure rainfall period, leading mosquito abundance activity. also found...
ABSTRACT The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which confers stability and shape to the cell, functions as scaffolding compartment during formation daughter cells plays an important role in motility invasion different life cycle stages these single celled organisms. To explore IMC proteome malaria parasite Plasmodium falciparum we applied proximity-dependent biotin identification (BioID)-based proteomics approach, using established marker protein...