A5100708840- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Proteoglycans and glycosaminoglycans research
- Retinal Imaging and Analysis
- Patient Satisfaction in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Luminescence and Fluorescent Materials
- Glycosylation and Glycoproteins Research
- Medicinal Plant Pharmacodynamics Research
- Probiotics and Fermented Foods
- Covalent Organic Framework Applications
- Retinopathy of Prematurity Studies
- Pharmacological Effects of Natural Compounds
- Bee Products Chemical Analysis
- Traditional Chinese Medicine Studies
- Intraocular Surgery and Lenses
- Optical Coherence Tomography Applications
- Rabbits: Nutrition, Reproduction, Health
- Optical Imaging and Spectroscopy Techniques
- Enzyme Production and Characterization
- Medical and Agricultural Research Studies
Baylor College of Medicine
2025
Tongren Hospital
2025
Shanghai Jiao Tong University
2025
University of Houston
2020-2024
Shandong Shierming Eye Hospital
2021-2023
Shandong University of Traditional Chinese Medicine
2021-2023
Weifang Medical University
2023
Eye & ENT Hospital of Fudan University
2016-2018
Fudan University
2016-2018
Beijing Shijitan Hospital
2014
Purpose To develop methods of collagen cross-linking (CXL) in the sclera for treatment progressive myopia and to investigate biomechanical histological changes that occur as a result. Methods Twenty 14-day-old guinea pigs were divided into 3 groups: group (CL, n = 8), non (NCL, control (n 4). The scleras right eyes CL surgically exposed riboflavin was dropped onto irradiation zone 20 seconds prior ultraviolet-A (UVA) irradiation. same procedure conducted on NCL but without UVA No group....
Purpose.: To evaluate the macular thickness/volume in Chinese myopic children using spectral-domain optical coherence tomography (SD-OCT) and assess its correlation with spherical equivalent refraction (SER), axial length (AL), sex, age. Methods.: A total of 194 eyes from (aged 6–17 years old) emmetropia (−0.5 diopters [D] < SER ≤ 0.5 D), low myopia (−3.0 D −0.5 moderate to high (SER −3.0 D) were recruited study. Each child underwent standardized ophthalmic examinations including visual...
Abstract Backgrounds Myopia has become a global public health problem. Children with early onset of myopia are at particular risk complications associated myopia. Younger children and greater initial myopic refractive errors progression. Therefore, it is essential to identify subjects high developing facilitate prevention in the stage, especially during preschool period. The purpose this study was determine whether premyopia can be predicted by easily obtainable parameters. Methods Data...
Abstract Background Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed vitro providing supporting epithelial cells (LESCs) during ex vivo expansion. We exogenous beneficial to LESCs Method Human (hLESCs) were isolated from donor corneas and mouse corneal progenitor line (TKE2) was obtained. The surrounding using immunocytochemistry, flow cytometry red blood...
Purpose: Hyaluronan (HA) is a major constituent of the extracellular matrix (ECM) that has high viscosity and essential for maintaining tissue hydration. In cornea, HA enriched in limbal region key component epithelial stem cell niche. upregulated after injury participating formation provisional matrix, role regulating wound healing process. This study investigated whether changes distribution before affects biomechanical properties cornea vivo. Methods: Corneas wild-type (wt) mice lacking...
Abstract Eye injury due to alkali burn is a severe ocular trauma that can profoundly affect corneal structure and function, including its biomechanical properties. Here, we assess the changes in mechanical behavior of mouse corneas response alkali‐induced by conducting longitudinal measurements using optical coherence elastography (OCE). A non‐contact air‐coupled ultrasound transducer was used induce elastic waves control alkali‐injured vivo, which were imaged with phase‐sensitive...
Purpose: To evaluate the refractive differences among school-aged children with macular or peripapillary fundus tessellation (FT) distribution patterns, using density (FTD) quantified by deep learning (DL) technology. Methods: The cross-sectional study included 1942 school aged six to 15 years, undergoing ocular biometric parameters, cycloplegic refraction, and photography. FTD was for both (6 mm) (4 regions, DL-based image processing applied 45° color photographs. Eyes exhibiting were...
This study aims to validate and revise the Spot Vision Screener referral criteria for detecting amblyopia risk factors (ARFs), visually significant refractive error (VSRE), amblyopia. In clinics, we gathered data from children aged 12 months 7 years. The validity of cut-off values was assessed using receiver operating characteristic (ROC) curves, with cycloplegic retinoscopy serving as a reference. These results were compared age-based 2021 AAPOS diagnostic thresholds. Additionally, this...
The corneal epithelium is a layer in the anterior part of eye that contributes to light refraction onto retina and ocular immune defense. Although an intact excellent barrier against microbial pathogens injuries, abrasions can lead devastating infections. Among them, Pseudomonas aeruginosa-associated keratitis often results severe deterioration tissue even blindness. Hence, discovery new drugs able not only eradicate infections, which are resistant antibiotics, but also elicit wound repair...
Purpose: Hyaluronan (HA) exists in two forms, high molecular weight HA (HMWHA) and low (LMWHA), which have distinct physiological functions. Therefore it is imperative to know the form of within pharmaceutical products, including eye products. This study developed an accurate, sensitive, quantitative method characterize Thereafter, effects HA-containing products on corneal wound healing were investigated. Methods: The MW distributions concentrations over counter determined by size exclusion...
A buildup of reactive oxygen species (ROS) occurs in virtually all pathological conditions. Hyaluronan (HA) is a major extracellular matrix component and susceptible to oxidation by (ROS), yet the precise chemical structures oxidized HA products (oxHA) their physiological properties remain largely unknown. This study characterized molecular weight (MW), structures, oxHA. For this, high-molecular-weight (HMWHA) was using increasing molar ratios hydrogen peroxide (H2O2) or hypochlorous acid...
To address the microstructure and biomechanical changes of sclera rabbits after negative lens application by spectacle frame apparatus.Five New Zealand seven weeks post-natal were treated with -8 D monocularly over course two weeks. Refractive errors axial length (AXL) measured at 1st, 7th 14th days induction period. Ultrastructure was determined electron microscopy. Biomechanical properties tested an Instron 5565 universal testing machine.Lens-induced (LI) eyes elongated more rapidly...
Background: This study aims to assess the efficacy of scleral collagen cross-linking method using glyceraldehyde solution for prevention lens-induced axial elongation in New Zealand rabbits and investigate biochemical microstructural changes that occur.Methods: The right eyes aged seven weeks were randomly divided into three groups: group (n = 6), non-crosslinking 5), untreated control 5). Eyes groups treated with a −8.00 Diopter spherical lens over course two weeks. effects achieved by...
Objective: To explore the characteristics of orthokeratology lenses designed for small correction zones and their effectiveness safety in long-term prevention control myopia children adolescents. Methods: It was a prospective cohort study that included myopic adolescents who received corneal reshaping treatment at Qingdao Eye Hospital Shandong First Medical University between January 2019 May 2020. The patients were randomly divided into two groups using computer-generated randomization,...
This study aimed to investigate the therapeutic effects of overnight orthokeratology (OK) lenses on anisometropes.We enrolled 178 anisometropes from August 2015 2017. We then divided these patients into 2 parts depending them wearing either monocular or binocular OK lenses. In part one, 47 myopic subjects (25 males and 22 females) were treated with in eyes only. also labeled as group contralateral nonmyopic control group. The initial average age was 12.35 ± 2.37 years (8-16 years). mean...
The study aims to assess two refractive instrument-based methods of vision screening (SureSight and PlusoptiX) detect amblyopia risk factors (ARFs) significant errors in Chinese preschool children develop referral criteria according the 2021 AAPOS guidelines. Eye examinations were conducted aged 61 72 months (n = 1,173) using a PlusoptiX photoscreener, SureSight autorefractor, cycloplegic retinoscopy (CR). Vision Screening Committee AAPOS's guidelines from adopted for comparison. Paired...
Abstract Purpose To investigate haemoglobin oxygenation in the visual cortex of myopic patients using functional near‐infrared spectroscopy (fNIRS). Methods The experiment consisted two parts. Part 1 examined changes before and after refractive correction patients. Subjects were divided into normal controls, uncorrected corrected myopes. 2 caused by lens‐induced myopia subjects, whether this activity recovered a period rest. Here, subjects three groups: emmetropes, rest group. group...
Objective To evaluate visual quality before and after screen-reading using doublepass retinal images, to analyze the relationship between refractive error stability of tear film amplitude accommodation. Methods This was a prospective self-controlled study based on 53 college students (106 consecutive eyes). Tear accommodation were assessed 1 hour with double-pass images. The differences in measurement data compared paired t tests independent samplest tests. A one-way ANOVA used...